Antioxidants and Self-Reported History of Kidney Stones: The National Health and Nutrition Examination Survey

Holoch, Peter A.; Tracy, Chad R.

doi:10.1089/end.2011.0130

Cited by 56 publications

(34 citation statements)

References 27 publications

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“…In another recent study serum levels of antioxidants were examined in adult participants of 1988 to 1994 NHANES III. 10 Mean levels of antioxidants, α -carotene, β -carotene and β -cryptoxanthin were significantly lower in participants with a self-reported history of kidney stones, while those with higher serum β -carotene and β -cryptoxanthin showed a tendency toward a decreasing prevalence of kidney stones.…”

Section: Clinical Datamentioning

confidence: 85%

Reactive Oxygen Species as the Molecular Modulators of Calcium Oxalate Kidney Stone Formation: Evidence from Clinical and Experimental Investigations

2013

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Purpose Idiopathic calcium oxalate kidney stones form while attached to Randall plaques, the subepithelial deposits on renal papillary surfaces. Plaque formation and growth mechanisms are poorly understood. Plaque formation elsewhere in the body is triggered by reactive oxygen species and oxidative stress. This review explores possible reactive oxygen species involvement in plaque formation and calcium oxalate nephrolithiasis. Materials and Methods A search of various databases for the last 8 years identified literature on reactive oxygen species involvement in calcium oxalate nephrolithiasis. The literature was reviewed and results are discussed. Results Under normal conditions reactive oxygen species production is controlled, increasing as needed and regulating crystallization modulator production. Reactive oxygen species overproduction or decreased antioxidants lead to oxidative stress, inflammation and injury, and are involved in stone comorbidity. All major chronic inflammation markers are detectable in stone patient urine. Patients also have increased urinary excretion of the IαI and the thrombin protein families. Results of a recent study of 17,695 participants in NHANES III (National Health and Nutrition Examination Survey) showed significantly lower antioxidants, carotene and β-cryptoxanthin in those with a kidney stone history. Animal model and tissue culture studies revealed that high oxalate, calcium oxalate and calcium phosphate crystals provoked renal cell reactive oxygen species mediated inflammatory responses. Calcium oxalate crystals induce renin up-regulation and angiotensin II generation. Nonphagocytic NADPH oxidase leads to reactive oxygen species production mediated by protein kinase C. The P-38 MAPK/JNK transduction pathway is turned on. Transcriptional and growth factors, and generated secondary mediators become involved. Chemoattractant and osteopontin production is increased and macrophages infiltrate the renal interstitium around the crystal. Phagocytic NADPH oxidase is probably activated, producing additional reactive oxygen species. Localized inflammation, extracellular matrix and fibrosis develop. Crystallization modulators have a significant role in inflammation and tissue repair. Conclusions Based on available data, Randall plaque formation is similar to extracellular matrix mineralization at many body sites. Renal interstitial collagen becomes mineralized, assisting plaque growth through the interstitium until the mineralizing front reaches papillary surface epithelium. Plaque exposure to pelvic urine may also be a result of reactive oxygen species triggered epithelial sloughing.

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Section: Clinical Datamentioning

confidence: 85%

Reactive Oxygen Species as the Molecular Modulators of Calcium Oxalate Kidney Stone Formation: Evidence from Clinical and Experimental Investigations

2013

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“…Several inflammatory markers were found to be elevated in patients with urolithiasis . Moreover, patients with urolithiasis were discovered to have lower serum antioxidant levels . The overproduction of reactive oxygen species and alterations of the antioxidant system, which induce inflammation, are key pathophysiological markers of cardiovascular diseases .…”

Section: Discussionmentioning

confidence: 99%

Urolithiasis is associated with an increased risk of stroke: a population‐based 5‐year follow‐up study

Chou

Chang

Chou

2018

Internal Medicine Journal

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“…Some researches have previously evaluated the possible role of oxidative stress in animal models by demonstrating increased markers of lipid peroxidation and oxygen free radicals in in vivo models of nephrolithiasis in porcine [36], canine and rat models [37]. Furthermore, one recent cross-sectional study identified a significant association between lower levels of alpha-carotene, beta-carotene and beta-cryptoxanthin and the prevalence of kidney stones [38]. Coffee is nowadays accepted as a rich source of compounds possessing antioxidant and radical scavenging activities [39,40,41].…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Coffee Intake and Risk of Urolithiasis

Wang¹,

Zhang²,

Mao³

et al. 2014

Urol Int

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Objective: Epidemiologic studies have reported various results relating coffee to urolithiasis. A meta-analysis of cohort and case-control studies was conducted to pool the relative risk (RR) estimates of the association between coffee and urolithiasis. Methods: Eligible studies were retrieved via both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary RR estimates. A dose-response meta-analysis was performed for studies reporting categorical RR estimates for a series of exposure levels. Results: A total of 6 studies (2 cohort and 4 case-control studies) on coffee intake were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest coffee consumption (OR = 0.70, 95% confidence interval 0.60-0.82) on the risk of urolithiasis. Coffee exhibited an inverse dose-response relationship with urolithiasis. In stratified analysis, a significant inverse association between coffee and urolithiasis was observed in study design, geographical region and gender subgroup. Conclusions: The overall current literature suggests that coffee intake is associated with a decreased risk of urolithiasis. Further efforts should be made to clarify the underlying biological mechanisms.

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Antioxidants and Self-Reported History of Kidney Stones: The National Health and Nutrition Examination Survey

Abstract: Lower levels of alpha-carotene, beta-carotene, and beta-cryptoxanthin are associated with a history of kidney stones and may indicate a role for these antioxidants in preventing stone formation.

Cited by 56 publications

References 27 publications

Reactive Oxygen Species as the Molecular Modulators of Calcium Oxalate Kidney Stone Formation: Evidence from Clinical and Experimental Investigations

Reactive Oxygen Species as the Molecular Modulators of Calcium Oxalate Kidney Stone Formation: Evidence from Clinical and Experimental Investigations

Urolithiasis is associated with an increased risk of stroke: a population‐based 5‐year follow‐up study

A Meta-Analysis of Coffee Intake and Risk of Urolithiasis

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