“…Their action includes restoration of thiol enzymes function, free radical scavenging, formation of non-toxic adducts, reduction in cisplatin uptake by renal cells, and increase in the urinary excretion of cisplatin (Santos 2012). The nephroprotective effect of diethyldithiocarbamate (DDTC), GSH, D-methionine, amifostine, sodium thiosulphate (STS), N-acetylcysteine (NAC), and lipoic acid has been demonstrated (Cvitkovic 1998;Wu et al 2005;Bae et al 2009); however, studies indicate that the thiol moiety react with cisplatin resulting in the formation of an inactive platinumthiol conjugate (Hausheer et al 1998).…”