Antioxidants and Inhibition of Cisplatin-Induced Kidney Injury: Role of Mitochondria

Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

“…The dietary antioxidants such as vitamins A, C, and E and some flavonoids might act as pro-oxidants under some specific conditions; vitamin C and quercetin, for example, induce free radical production in the presence of transition metals (Laughton et al 1989;Tirosh et al 1996;Schmalhausen et al 2007;Santos 2012). Some studies have shown that the pro-oxidant activity of some flavonoids potentiate the antitumor activity of cisplatin.…”

“…Their action includes restoration of thiol enzymes function, free radical scavenging, formation of non-toxic adducts, reduction in cisplatin uptake by renal cells, and increase in the urinary excretion of cisplatin (Santos 2012). The nephroprotective effect of diethyldithiocarbamate (DDTC), GSH, D-methionine, amifostine, sodium thiosulphate (STS), N-acetylcysteine (NAC), and lipoic acid has been demonstrated (Cvitkovic 1998;Wu et al 2005;Bae et al 2009); however, studies indicate that the thiol moiety react with cisplatin resulting in the formation of an inactive platinumthiol conjugate (Hausheer et al 1998).…”