Antioxidants and cataract: (Cataract induction in space environment and application to terrestrial aging cataract)

Bantseev, Vladimir; Bhardwaj, Ratan; Rathbun, William B.; Nagasawa, H. T.; Trevithick, John R.

doi:10.1080/15216549700203661

Cited by 11 publications

(12 citation statements)

References 9 publications

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“…Treatment with antioxidants and BBIC conferred significant protection against iron-ion radiation-induced cataract formation. These observations are consistent with the reports that treatment with vitamin E alone or in combination with vitamin C, lipoic acid and taurine was effective in delaying the onset or reducing the severity of 60 Co cradiation-induced cataract formation in rat lenses (31,52). Other antioxidants have also been shown to inhibit radiation-induced cataracts [e.g.…”

supporting

confidence: 91%

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

et al. 2010

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The present study was undertaken to investigate the ability of dietary supplements to reduce the formation and severity of cataracts in mice irradiated with high-energy protons or iron ions, which are important components of the radiation encountered by astronauts during space travel. The mice were exposed to proton or iron-ion radiation and fed with a control diet or diets supplemented with the soybean-derived protease inhibitor, Bowman-Birk inhibitor (BBI), in the form of BBI Concentrate (BBIC) or an antioxidant formulation [containing l-selenomethionine (SeM), N-acetyl cysteine (NAC), ascorbic acid, co-enzyme Q10, alpha-lipoic acid and vitamin E succinate] both before and after the radiation exposure. At approximately 2 years after the radiation exposure, the animals were killed humanely and lenses were harvested and characterized using an established classification system that assigns discrete scores based on the severity of the lens opacifications. The results showed that exposure to 1 GeV/nucleon proton (3 Gy) or iron-ion (50 cGy) radiation significantly increased the cataract prevalence and severity in CBA/J mice to levels above the baseline levels of age-induced cataract formation in this mouse strain. Treatment with BBIC or the antioxidant formulation significantly reduced the prevalence and severity of the lens opacifications in the mice exposed to iron-ion radiation. Treatment with BBIC or the antioxidant formulation also decreased the severity of the lens opacifications in the mice exposed to proton radiation; however, the decrease did not reach statistical significance. These results indicate that BBIC and the antioxidant formulation evaluated in this study could be useful for protecting astronauts against space radiation-induced cataracts during or after long-term manned space missions.

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supporting

confidence: 91%

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

et al. 2010

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“…A cataract is an opacity of the eye lens that interferes with vision [6]. Ionizing radiation is known to be one of the most potent cataractogenic agents [7].…”

Section: Introductionmentioning

confidence: 99%

The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model

Kocer

Taysı

Ertekin

et al. 2006

Graefe's Arch Clin Exp Ophthalmol

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“…In a study of the anticataractogenic effects of a superoxide dis- mutase-like compound (Tempol ) in rabbits, Sasaki et al [14] used the same dose and dose rate as in our current study. In addition to Tempol , several other agents including Walter Reed compounds (WR-2721 and WR 77913) [12], ascorbic acid [49], tocopherol, R-alpha-lipoic acid, and taurin [13] have been tested in vitro in lens protection against x-rays, UVBs, and oxidative injury. This study's objective is to analyze the in vitro effects of WR-1065, the active metabolite of amifostine, and ADT on bovine lens epithelial cell mortality and intracellular GSH pool variations following x-ray exposure.…”

Section: Discussionmentioning

confidence: 99%

“…In experimental models, previous morphological and histological studies of irradiated lenses have revealed that several antioxidant agents and Walter Reed compounds have radioprotective effects against radiation-induced cataracts [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation

Belkacémi¹,

Rat²,

Piel³

et al. 2001

Int. J. Cancer

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SUMMARY Lens epithelium disorganization, glutathione (GSH) depletion, and epithelial cell death have been incriminated in the cytopathogenic mechanisms that lead to cataract formation following UVB and x-ray exposures. The objective of this study was to determine the in vitro capacity of the aminothiol WR-1065, the active metabolite of amifostine, and anetholedithiolethione (ADT or Sulfarlem ) to protect bovine lens epithelial cells against x-ray irradiation. WR-1065 and ADT were used at a concentration of 20 M. A single dose of 10 Gy was delivered at a rate of 2 Gy/min. Fluorimetric assays were then performed using a neutral red probe to evaluate cell viability, a Hoechst 33342 probe (HO) to evaluate nuclear condensation and apoptosis, and a monobromobimane probe to estimate the intracellular GSH pool. Twenty-four hours after x-ray exposure, cells pretreated with WR-1065 showed increased GSH levels, improved cell viability, and decreased HO fluorescence in addition to a lesser proportion of cells with apoptotic nuclear modifications. Between 72 and 120 hr postirradiation, ADT-pretreated cells also showed increased intracellular GSH levels and cell viability and decreased HO fluorescence and apoptotic cell morphology. This in vitro study demonstrates that WR-1065 and ADT protects lens epithelial cells from x-ray injury; thus, ADT and amifostine are appropriate candidates for clinical trials in humans. They are currently used in preventing radiation-induced xerostomia and should be further tested in the prevention of late radiation-induced ocular complications such as sicca syndrome and cataract.

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Antioxidants and cataract: (Cataract induction in space environment and application to terrestrial aging cataract)

Cited by 11 publications

References 9 publications

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model

Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation

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