Antioxidants and Cancer Therapy: A Systematic Review

Ladas, Elena J.; Jacobson, Judith S.; Kennedy, Deborah D.; Teel, Katherine; Fleischauer, Aaron; Kelly, Kara M.

doi:10.1200/jco.2004.03.086

Cited by 228 publications

(144 citation statements)

References 57 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…No evidence has been found that antioxidant vitamin supplements reduce the toxicity associated with chemotherapy [64]. Some authors even advise against the use of antioxidant supplements during chemotherapy or radiotherapy [65].…”

Section: Other Dietary Macro-and Micronutrientsmentioning

confidence: 99%

Lifestyle changes and breast cancer prognosis: a review

Kellen

Vansant

Christiaens

et al. 2008

Breast Cancer Res Treat

View full text Add to dashboard Cite

Section: Other Dietary Macro-and Micronutrientsmentioning

confidence: 99%

Lifestyle changes and breast cancer prognosis: a review

Kellen

Vansant

Christiaens

et al. 2008

Breast Cancer Res Treat

View full text Add to dashboard Cite

“…1,2 Currently, the use of antioxidant supplements during radiation therapy is a controversial issue, since it is feared that they could interfere with treatment. 3,4 We conducted a double-blind, placebo-controlled, randomized trial among head and neck cancer patients treated by radiation therapy to assess the effects of a supplementation combining alpha tocopherol and beta carotene on outcomes of head and neck cancer patients.…”

mentioning

confidence: 99%

Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long‐term effects on recurrence and mortality: A randomized trial among head and neck cancer patients

Meyer

Bairati

Fortin

et al. 2008

Intl Journal of Cancer

110

View full text Add to dashboard Cite

There has been concern that the efficacy of radiation therapy may be reduced when patients smoke or take antioxidant vitamins during treatment. Cancer prevention trials with beta carotene supplements documented adverse effects only among smokers. We conducted a randomized trial with alpha tocopherol (400 IU/day) and beta carotene (30 mg/day) supplements among 540 head and neck cancer (HNC) patients treated by radiation therapy. We examined whether smoking during radiation therapy modified the effects of the supplementation on HNC recurrence and on mortality. During the follow-up, 119 patients had a HNC recurrence and 179 died. Cox models were used to test the interaction between smoking and supplementation and to estimate the hazard ratios (HR) for HNC recurrence and death associated with the supplementation. Cigarette smoking either before or after radiation therapy did not modify the effects of the supplementation. In contrast, the interactions between supplementation and cigarette smoking during radiation therapy were statistically significant for HNC recurrence (p 5 0.03), all-cause mortality (p 5 0.02) and mortality from the initial HNC (p 5 0.04). Among cigarette smokers, the HR were 2.41 (95% CI: 1.25-4.64) for recurrence, 2.26 (95% CI: 1.29-3.97) for all-cause mortality and 3.38 (95% CI: 1.11-10.34) for HNC mortality. All corresponding HR among nonsmokers were close to 1. These results could best be explained by the hypothesis that the combined exposures reduced the efficacy of radiation therapy. Particular attention should be devoted to prevent patients from both smoking and taking antioxidant supplements during radiation therapy. ' 2007 Wiley-Liss, Inc.

show abstract

“…[24][25][26] The idea that antioxidants might protect cancer cells from effects of cytotoxic chemotherapy or radiation is not yet clearly supported by evidence. 11,27 However, the ability to study supplement use rigorously in both cancer prevention and treatment has been limited by the lack of standardization of supplement formulations and dosing. [28][29][30] Despite the unclear benefits of supplements, use tends to increase after a cancer diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Supplement use is common in patients with cancer (26% to 87%) and in patients with liver disease (27% to 43%), [7][8][9] despite the lack of clear evidence regarding efficacy or safety. 7,10,11 Our goal was to measure the prevalence of dietary supplement use in a prospective study of subjects with HCC and to determine demographic and clinical characteristics associated with supplement use. In this study, we also examined whether use of these agents was associated with overall survival.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplement Use Among Patients With Hepatocellular Carcinoma

et al. 2014

Self Cite

View full text Add to dashboard Cite

Background. More than 50% of US adults, and an even larger proportion of cancer patients, use dietary supplements. Since many supplements require hepatic metabolism, they may be particularly likely to cause toxicities in patients with hepatocellular carcinoma (HCC). However, little is known about supplement use in patients with HCC. Methods. From 2008 to 2012, we gave newly diagnosed HCC patients at our institution a standardized questionnaire about dietary supplement use, demographic factors, and clinical characteristics. We then followed patients for four years or until time to death to examine the relationship with supplement use. Results. Of 146 patients, 71% had used vitamins and 45% herbal supplements. Most commonly used supplements were antioxidants (51%), multivitamins (46%), vitamin D (25%), and milk thistle (23%). People in mid-higher income brackets were more likely to use herbal supplements (19% of those earning <$30 000, 50% of those earning $30 000-60 000, and 34% of those earning >$60 000 used supplements). Hepatitis C (HCV) patients were more likely to use milk thistle than those without HCV (30% vs 13%, P = .03), and patients with hepatitis B (HBV) were more likely than non-HBV patients to use vitamin C (32% vs 14%, P = .01). Supplement use was not associated with overall survival. Conclusions. Like cancer patients in other studies, the majority of our HCC patients used dietary supplements. Supplement use was not associated with overall survival but should be studied in larger patient samples.

show abstract

Antioxidants and Cancer Therapy: A Systematic Review

Cited by 228 publications

References 57 publications

Lifestyle changes and breast cancer prognosis: a review

Lifestyle changes and breast cancer prognosis: a review

Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long‐term effects on recurrence and mortality: A randomized trial among head and neck cancer patients

Dietary Supplement Use Among Patients With Hepatocellular Carcinoma

Contact Info

Product

Resources

About