Antioxidants - a combat against oxidative stress in dementia

Latif, Fakhar; Imran, M

doi:10.1016/j.amsu.2022.104632

Cited by 2 publications

(2 citation statements)

References 11 publications

(14 reference statements)

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“…Antioxidants had received increasing attention for their protective effects against oxidative stress-mediated pathological processes and played a vital role in both the food system and the human body to reduce the oxidative process and harmful effects of ROS. [40][41][42] In this paper, five novel chitosan oligosaccharide quinolinyl quaternary ammonium derivatives (2a-2e) with high antioxidant activity were synthesized and their DPPH radical scavenging activity, superoxide radical scavenging activity, hydroxyl radical scavenging activity, as well as reducing power are shown in Figure 3-6, respectively.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities

et al. 2023

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In this study, five new chitosan oligosaccharide quaternary ammonium derivatives bearing quinoline are synthesized by reaction between 6‐O‐chloroacetyl‐2‐N, N, N‐trimethyl quaternary ammonium salt chitosan oligosaccharide (CTCOS, compound 1) and quinoline derivatives. The derivatives are characterized by analytical techniques including Fourier Transform Infrared (FTIR), 1H Nuclear Magnetic Resonance (1H NMR) spectroscopy, and elemental analysis. The obtained results confirm that quinoline groups are successfully introduced into the CTCOS molecule. Meanwhile, the antioxidant activities of the prepared chitosan oligosaccharide derivatives are evaluated in vitro. The experimental results show that the derivatives have excellent free radical scavenging ability. The free radical scavenging abilities are all over 75% at the concentration of 1.6 mg mL−1. Moreover, antibacterial tests show that derivative 2e has the best antibacterial activities. Its minimum inhibitory concentration (MIC) value and minimum bactericidal concentration (MBC) value against Staphylococcus aureus and Escherichia coli are 0.0625 and 0.03125 mg mL−1, respectively. In addition, the cytotoxicity of chitosan oligosaccharide and its derivatives is examined by MTT colorimetric assay in RAW 264.7 macrophages, observing that all derivatives are non‐cytotoxic. Consequently, the findings indicate that the enhanced antioxidant activity, antibacterial activity, and biocompatibility of these chitosan oligosaccharide derivatives can enlarge the scope of the application of chitosan oligosaccharides, particularly as antioxidant and antibacterial agents in food packaging, pharmaceutical, cosmetics industries, and other fields.

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Section: Antioxidant Activitymentioning

confidence: 99%

Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities

et al. 2023

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“…For example, reactive oxygen species (ROS), if not effectively removed, may harm proteins, lipids, and deoxyribonucleic acid (DNA) in cells, ultimately leading to cellular damage and cell death [ 11 , 12 ]. A variety of human diseases have been observed to have a bearing on oxidative stress, e.g., cancer [ 13 ], dementia [ 14 ], cardiovascular diseases, neurodegenerative diseases [ 15 , 16 ], hyponatremia [ 17 ], diabetes [ 18 ], uterine fibroid [ 19 ], and colorectal cancer [ 20 ]. Organisms contain natural defense systems against oxidative stress, including enzymatic antioxidant and non-enzymatic antioxidant systems.…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant Activities In Vitro and In Vivo and Extraction Conditions Optimization of Defatted Walnut Kernel Extract

Zhou,

Gong,

et al. 2023

Foods

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The objective of this study was to determine the antioxidant activities of defatted walnut kernel extract (DWE) and whole walnut kernel extract (WE) in vitro and in vivo. Three spectrophotometric methods, DPPH, ABTS, and FRAP, were used in in vitro experiments, and mice were used in in vivo experiments. In addition, response surface methodology (RSM) was used to optimize reflux-assisted ethanol extraction of DWE for maximum antioxidant activity and total phenolic content. The results of in vitro experiments showed that both extracts showed antioxidant activity; however, the antioxidant activity of DWE was higher than that of WE. Both extracts improved the mice’s oxidative damage status in in vivo studies. An ethanol concentration of 58%, an extraction temperature of 48 °C, and an extraction time of 77 min were the ideal parameters for reflux-assisted ethanol extraction of DWE. The results may provide useful information for further applications of defatted walnut kernels and the development of functional foods.

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Antioxidants - a combat against oxidative stress in dementia

Cited by 2 publications

References 11 publications

Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities

Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities

The Antioxidant Activities In Vitro and In Vivo and Extraction Conditions Optimization of Defatted Walnut Kernel Extract

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