Antioxidant vitamins and magnesium and the risk of hearing loss in the US general population

Abstract

Dietary intakes of antioxidants and magnesium are associated with lower risks of hearing loss.

Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

“…Furthermore, this effect had a statistically significant interaction with noise, with previous noise exposure being associated with more severe hearing loss as a function of poorer diet, after adjusting for other risk factors [Spankovich and Le Prell, 2014]. Choi et al [2014] used a different analytic approach, including nutrient-specific analysis. They reported higher intakes of β-carotene, vitamin C, and Mg, as estimated by 24-hour dietary recall and supplement use, were associated with lower (better) speech PTAs and high-frequency PTAs in 20- to 69-year-olds [Choi et al, 2014].…”

Associations between dietary quality, noise, and hearing: Data from the National Health and Nutrition Examination Survey, 1999–2002

“…These supplemented doses sharply contrast with dietary intake, and several prospective studies assessing the association of vitamin intake with hearing in the general population have not suggested benefit (Shargorodsky et al, 2010; Polanski & Cruz, 2013). However, multiple epidemiological studies suggest healthy eating habits which provide recommended nutrient intake amounts may confer some long-term benefit, with the specific nutrients and dietary components assessed varying across analyses (Gopinath et al, 2010b; Gopinath et al, 2011; Spankovich et al, 2011; Choi et al, 2013; Heine et al, 2013; Péneau et al, 2013; Spankovich & Le Prell, 2013). …”

“…Some of the nutrients suggested to play a role in human hearing are vitamins, including vitamins A, B (specifically B 2 , B 9 , and B 12 ), C, and E (Weijl et al, 2004; Durga et al, 2007; Michikawa et al, 2009; Gopinath et al, 2011; Spankovich et al, 2011; Choi et al, 2013). However, there are also studies that report no statistically significant relationships between these specific vitamins and hearing (Berner et al, 2000; Michikawa et al, 2009; Shargorodsky et al, 2010; Gopinath et al, 2011; Péneau et al, 2013).…”

“…However, there are also studies that report no statistically significant relationships between these specific vitamins and hearing (Berner et al, 2000; Michikawa et al, 2009; Shargorodsky et al, 2010; Gopinath et al, 2011; Péneau et al, 2013). Some of the minerals suggested to play a role in hearing include magnesium (Mg) (Joachims et al, 1993; Attias et al, 1994; 2004; Spankovich et al, 2011; Choi et al, 2013) and selenium (Se) (Weijl et al, 2004; Chuang et al, 2007), although there are also studies reporting no statistically significant relationship between Mg and hearing (Walden et al, 2000). One of the key challenges for single-nutrient analyses is that diets include a complex combination of nutrients that have complex interactions.…”

Cellular Mechanisms of Age-Related Hearing Loss

“…The ACEMg treatment was administered to guinea pigs (Le Prell et al 2007 ) and CBA/J mice (Le Prell et al 2011 ) showing reduced permanent threshold shifts after NIHL and also reduced threshold shift after gentamicin ototoxicity (Le Prell et al 2014 ). Studies in humans indicate that regular dietary intake of antioxidants correlates with lower risks of hearing loss (Durga et al 2007 ;Shargorodsky et al 2010 ;Choi et al 2014 ). Chapter 6 by Spankovich discusses epidemiological data on the role of nutrients in hearing loss prevention in humans.…”