Antioxidant therapy prevents ethylene glycol-induced renal calcium oxalate crystal deposition in Wistar rats

Naghii, Mohammad Reza; Eskandari, Eslam; Mofid, Mahmood; Jafari, Mehdi; Asadi, Mohammad Hossein

doi:10.1007/s11255-014-0658-5

Cited by 21 publications

(14 citation statements)

References 36 publications

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“…For example, the protective action of co-supplementation of single or multiple doses of vitamins C and E against cisplatin-induced AKI has been investigated in mice, and the results indicated that although single-dose and multidose co-supplementation of vitamins C and E rendered significant protection against cisplatin-induced AKI in mice, the multidose administration of vitamins provided a better protection [28]. This result was also confirmed last year by other research groups, in which scientists demonstrated that the combination was more effective than each individual agent in reducing oxalate-induced oxidative renal injury, as well as subsequent calcium oxalate crystal deposition in recurrent stone formers [38,39]. Therefore, the multidose combination of vitamins C and other vitamins at their lower doses could be regarded as an effective therapy mode for protecting mice against cisplatin-induced AKI because of the rare side effect from high vitamin intakes.…”

Section: Development Of New Therapy Modes With Vitamin E Against Akimentioning

confidence: 67%

Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

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Abstract. It has been well-known for many years now that vitamin E is an essential nutrient; however, some of the physiological functions of this vitamin are still far from being understood. In recent years, a series of preclinical and clinical studies proposed a protective role of vitamin E on acute kidney injury (AKI), which has a high morbidity rate and mortality rate in clinical investigations. Based on the benefits associated with vitamin E, such as strong antioxidant function, low toxicity, rare side-effects, and low cost, this therapy strategy has garnered an extensive amount of interest in the scientific community for the development of new therapy modes against AKI. In this review, a concise overview of the application of vitamin E in the treatment of AKI is provided as well as a summary of a series of published data regarding the combination therapy modes and detailed therapy mechanisms of vitamin E-based therapy against AKI. At present, there are critical points of this therapy mode that are still in need of further clarification, meaning the current understanding of the role of vitamin E in the treatment of AKI remains incomplete. However, the development of more reliable pharmacological or biotechnical strategies with vitamin E for the eventual treatment of patients with AKI may guide the next chapter of vitamin E research.

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Section: Development Of New Therapy Modes With Vitamin E Against Akimentioning

confidence: 67%

Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

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“…Ascorbic acid‐2‐sulfate is a metabolite of vitamin C and acts as a radical scavenger against oxidative stress (Takebayashi, Tai, Gohda, & Yamamoto, ). The administration of natural vitamin C as an antioxidant has been found to protect against nephrolithiasis in humans and experimental animals (Naghii, Eskandari, Mofid, Jafari, & Asadi, ). The elevated level of plasma ascorbic acid‐2‐sulfate in the SA‐treated group also reflects the antioxidant effect of SA capsules in crystal nephropathy.…”

Section: Discussionmentioning

confidence: 99%

The mechanism of the preventive effect of Shen’an capsule on the calcium oxalate crystal‐induced early renal injury based on metabolomics

Fan¹,

Hou

Zhu

et al. 2018

Biomedical Chromatography

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Kidney stone disease is a worldwide metabolism-associated disorder with a high incidence of renal dysfunction. However, effective methods to prevent crystalline nephropathy are still lacking owing to the absence of aetiological research. Shen'an (SA) capsules are prepared from Chinese medicinal compounds and are considered a promising treatment for the prevention of crystal-induced renal injury. In this study, 24 mice were randomly divided into four groups: saline, oxalate, SA-treated (via preventive administration) and SA-only groups. A metabolomics analysis based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to explore the plasma metabolic profiles among the different groups. The amount of crystal deposition and the decline in kidney function were significantly alleviated by the use of SA capsule. A total of 24 metabolites that showed a reversal trend following SA capsule administration were identified as plasma biomarkerss of the preventive effects of SA capsules on crystal-induced renal injury. Most of these metabolites were involved in the metabolisms of lipid metabolism, energy metabolism, glutathione metabolism and vitamin metabolism. In conclusion, SA capsules exert a preventive effect in mice with crystal-induced kidney injury via the regulation of multiple metabolic pathways.

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“…In vivo and in vitro studies have demonstrated that hyperoxaluria results in production of superoxide and hydroxyl free radicals causing oxidative stress, cell membrane rupture, and cell injury, and leads to CaOx crystal adherence and retention in renal tubules [26][27][28]. Several studies have shown that antioxidants can protect against oxidative injury by oxalate and crystal deposition [29,30]. From this it can be speculated that the inhibitory effect of D. styracifolium on CaOx crystal deposition in renal tubules could have also been due to its antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Antilithic effects of extracts from different polarity fractions of Desmodium styracifolium on experimentally induced urolithiasis in rats

Xiang

Zhou

et al. 2015

Urolithiasis

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Desmodium styracifolium (D. styracifolium) has been widely used in traditional Chinese medicine for the treatment of urolithiasis. This work was undertaken to investigate extracts from different polarity fractions of D. styracifolium for possible antilithic effects as well as antioxidant potential to explore the underlying phytochemically active constituents of this plant. The extracts of D. styracifolium were divided into four different polarity fractions by petroleum ether (Fr. PE), chloroform (Fr. CH), ethyl acetate (Fr. EA), and n-butyl alcohol (Fr. NB). The antilithic and antioxidant effects were evaluated and compared in vivo on an animal model of calcium oxalate (CaOx) urolithiasis, which was established by administration of 1 % ethylene glycol along with 2 % ammonium chloride in drinking water for 28 days. A total of 60 male Sprague-Dawley rats were randomly divided into six groups: normal control group, lithogenic group, and four different polarity fractions of D. styracifolium-treated groups. At the end of the study, urine, blood, and kidney tissue samples were all collected for evaluation. Among the four polarity fractions of D. styracifolium extracts, the Fr. PE and Fr. NB treatment significantly reduced the CaOx crystal deposition in kidneys, prevented the renal toxic changes like pH, Cr, and BUN. In addition, Fr. PE and Fr. NB treatment significantly decreased urinary excretion of oxalate along with a increase of citrate excretion. The increased amounts of malondialdehyde and decreased activities of superoxide dismutase, catalase, and glutathione peroxidase were detected in lithogenic group, D. styracifolium extracts treatment prevented the oxidative stress changes especially for the Fr. PE and Fr. NB extracts. In conclusion, our data suggest that the extracts from D. styracifolium possess the antiurolithic activity, possibly mediated through the inhibition of CaOx crystal aggregation as well as the alleviation of oxidative injury in the kidney, and the Fr. PE and Fr. NB extracts are the active fractions of D. styracifolium extract.

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Antioxidant therapy prevents ethylene glycol-induced renal calcium oxalate crystal deposition in Wistar rats

Abstract: Results showed a beneficial effect on treating and superior renal protection for preventing stone deposition in the rat kidney. These results provide a scientific rationale for preventive and treatment roles of antioxidant nutrient complex in human kidney stone disease.

Cited by 21 publications

References 36 publications

Protective effect of vitamin E against acute kidney injury

Protective effect of vitamin E against acute kidney injury

The mechanism of the preventive effect of Shen’an capsule on the calcium oxalate crystal‐induced early renal injury based on metabolomics

Antilithic effects of extracts from different polarity fractions of Desmodium styracifolium on experimentally induced urolithiasis in rats

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