Antioxidant system in system in the organs of different ade rats exposed to exogenous estrogens

Abstract

Breast cancer (BC) is the most common cancer and the second leading cause of cancer death in the world. It is a leader in cancer incidence structure of the female population in the most economically developed countries. For example, It was estimated that almost 1.7 million cases of female breast cancer were diagnosed worldwide, corresponding to a rate of 43 per 100,000 and about 522,000 females (13 per 100,000 populations) have died from breast cancer globally during 2012. Deaths of women from breast cancer has increased more than 2.5 times over the past 10 years and won first place. Nutrition makes 30-35 % of the risk factors that promote occurrence of tumors. Products containing veterinary preparations is extremely dangerous for human health: hormonal growth promoters-stilbenes, steroids possess carcinogenic activity to cause a violation of puberty and reproductive capacity. Hormones are not completely destroyed by heat treatment products, so remain, though sometimes in smaller doses in meat, milk, eggs, vegetables and fruits. Steroid hormones are destroyed by heat treatment less all. Tumour biology plays important role in breast cancer survival. The aim was to study the state of lipid peroxidation and antioxidant system in the organs of rats of different ages exposed to exogenous estrogens to determine the trigger mechanisms for the development of tumors. Alimentary estrogen exposure caused an increased lipid peroxidation in animals in pubertal period and mature females. There have been varying degrees of peroxidation intensification depending on the age and organ specificity: the highest elevation of control indexes was noted in blood serum. The kidneys were the greatest resistance to the identified exogenous estrogens action. At females in pubertal period prooxidant reactions of excessive response force in the brain and liver of mature animals. In the kidney of female from experimental groups found decrease in the content of reduced glutathione indicates a risk of disruption to the detoxification system. This may lead to an accumulation of free radicals that are initiating factor of proliferative processes. The concentration of reduced glutathione in the brain tissue is sufficiently robust indicator. Therefore, reducing the level of the peptide in the brain of rats in the prepubescent period is a negative predictor of integral afferent system destruction. There was a discrete organ changes in the activity of enzymes of antioxidant protection depended on the age of the animals and indicated on imbalance of glutathione system enzymes works. Since the