Antioxidant supplementation during treatment of outpatient dogs with parvovirus enteritis ameliorates oxidative stress and attenuates intestinal injury: A randomized controlled trial

Chethan, G.E.; De, Ujjwal Kumar; Singh, Mithilesh; Chander, Vikas; Raja, Raguvaran; Paul, Babul Rudra; Choudhary, Om Prakash; Thakur, Neeraj; Sarma, Kalyan; Prasad, Hridayesh

doi:10.1016/j.vas.2023.100300

Cited by 4 publications

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors evaluated oxidative stress on the basis of GST activity and nitric oxide and MDA concentration in plasma. Chethan et al (2023) also reported similar results with markedly reduced concentrations of MDA, nitric oxide, and IFABP-2 in CPV-positive dogs supplemented with NAC, resveratrol, and ascorbic acid compared to the control group, which only received supportive therapy [176]. Supplementation with NAC and resveratrol was also found to markedly improve total leukocyte and neutrophil count in CPV-affected dogs.…”

Section: Parvovirusmentioning

confidence: 77%

N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals

Tieu,

Charchoglyan,

Paulsen

et al. 2023

Antioxidants

View full text Add to dashboard Cite

N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine, has been widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s and the 1980s, respectively. NAC possesses antioxidant, cytoprotective, anti-inflammatory, antimicrobial, and mucolytic properties, making it a promising therapeutic agent for a wide range of diseases in both humans and domesticated animals. Oxidative stress and inflammation play a major role in the onset and progression of all these diseases. NAC’s primary role is to replenish glutathione (GSH) stores, the master antioxidant in all tissues; however, it can also reduce levels of pro-inflammatory tumor necrosis factor-alpha (TNF-∝) and interleukins (IL-6 and IL-1β), inhibit the formation of microbial biofilms and destroy biofilms, and break down disulfide bonds between mucin molecules. Many experimental studies have been conducted on the use of NAC to address a wide range of pathological conditions; however, its effectiveness in clinical trials remains limited and studies often have conflicting results. The purpose of this review is to provide a concise overview of promising NAC usages for the treatment of different human and domestic animal disorders.

show abstract

Section: Parvovirusmentioning

confidence: 77%

N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals

Tieu,

Charchoglyan,

Paulsen

et al. 2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Data generated throughout this study support the notion that the daily administration of 1 × 10 9 cfu of DE-CA9 TM in healthy Beagle dogs is safe and does not affect markers of general health and fecal scores. Furthermore, DE-CA9 TM administration had a positive effect on some serum markers of oxidative stress (i.e., AOPP, d-ROMS, and TBARS), which have previously been found to be abnormal in dogs with acute and chronic gastrointestinal disease [ 24 , 65 , 66 ]. Such possible antioxidative effects of DE-CA9 TM may also play a role in supporting healthy ageing [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of the Probiotic Bacillus subtilis DE-CA9TM on Fecal Scores, Serum Oxidative Stress Markers and Fecal and Serum Metabolome in Healthy Dogs

Allenspach,

Sung,

Ceron

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

Background: There is increasing interest in the use of Bacillus species as probiotics since their spore-forming ability favors their survival in the acidic gastric environment over other probiotic species. The subsequent germination of B. subtilis to their vegetative form allows for their growth in the small intestine and may increase their beneficial effect on the host. B. subtilis strains have also previously been shown to have beneficial effects in humans and production animals, however, no reports are available so far on their use in companion animals. Study design: The goal of this study was therefore to investigate the daily administration of 1 × 109 cfu DE-CA9TM orally per day versus placebo on health parameters, fecal scores, fecal microbiome, fecal metabolomics, as well as serum metabolomics and oxidative stress markers in ten healthy Beagle dogs in a parallel, randomized, prospective, placebo-controlled design over a period of 45 days. Results: DE-CA9TM decreased the oxidative status compared to controls for advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS) and reactive oxygen metabolites (d-ROMS), suggesting an antioxidant effect of the treatment. Fecal metabolomics revealed a significant reduction in metabolites associated with tryptophan metabolism in the DE-CA9TM-treated group. DE-CA9TM also significantly decreased phenylalanine and homocysteine and increased homoserine and threonine levels. Amino acid metabolism was also affected in the serum metabolome, with increased levels of urea and cadaverine, and reductions in N-acetylornithine in DE-CA9TM compared to controls. Similarly, changes in essential amino acids were observed, with a significant increase in tryptophan and lysine levels and a decrease in homocysteine. An increase in serum guanine and deoxyuridine was also detected, with a decrease in beta-alanine in the animals that ingested DE-CA9TM. Conclusions: Data generated throughout this study suggest that the daily administration of 1 × 109 cfu of DE-CA9TM in healthy Beagle dogs is safe and does not affect markers of general health and fecal scores. Furthermore, DE-CA9TM administration had a potential positive effect on some serum markers of oxidative stress, and protein and lipid metabolism in serum and feces.

show abstract

“…Herbal medicines, as a result of their well-known antioxidant properties, find ample justification in young dogs with parvovirosis, where the role of oxidative stress is evident [ 58 ] and their beneficial effects on the immune response to bacterial attack in weaning puppies is obvious [ 59 ], as also recently confirmed by Chetan et al [ 60 ] in evaluating the role of nutraceuticals combined with pharmacological therapy in puppies aged between 1.5 and 6 months affected by parvovirus. Essential oils of eucalyptus, lemongrass, and thyme have demonstrated antiparvovirus canine type 2 (CPV-2) activity in vitro [ 61 ].…”

Section: Use Of Herbal Medicine In Puppiesmentioning

confidence: 98%

Phytotherapeutic Approaches in Canine Pediatrics

Quintavalla

2024

Veterinary Sciences

View full text Add to dashboard Cite

Phytotherapy is a clinical modality that incorporates botanical remedies as part of the therapeutic approach. It is a very ancient branch of medicine that is currently undergoing a renaissance, evident in the numerous preparations available on the market. The majority of these formulations are for preventive and curative use in adult animals. Experimental experiences in the pediatric age group are particularly scarce within the existing literature. Since these products are readily accessible, dog owners often turn to them due to their ease of availability, a preference for self-medication, and the perception that herbs are safer, gentler, and less expensive than conventional medications, often leading them to bypass seeking the advice of experienced professionals. The purpose of this review is to illustrate, on the basis of the currently available bibliography, phytotherapeutic approaches in canine pediatrics, paying particular attention to the adverse effects resulting from the use of certain plants, even when used in conjunction with some synthetic drugs. Consequently, it becomes evident that further clinical and more relevant studies, specifically focusing on puppies, are needed to increase knowledge about the effects of herbal remedies.

show abstract

Antioxidant supplementation during treatment of outpatient dogs with parvovirus enteritis ameliorates oxidative stress and attenuates intestinal injury: A randomized controlled trial

Cited by 4 publications

References 59 publications

N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals

N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals

Effect of the Probiotic Bacillus subtilis DE-CA9TM on Fecal Scores, Serum Oxidative Stress Markers and Fecal and Serum Metabolome in Healthy Dogs

Phytotherapeutic Approaches in Canine Pediatrics

Contact Info

Product

Resources

About