Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis

Anwar, Mumtaz; Ahmad, Shabeer; Akhtar, Reyhan; Mahmood, Akhtar; Mahmood, Safrun

doi:10.1177/1533034617707598

Cited by 15 publications

(12 citation statements)

References 127 publications

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“…It was found these mRNAs function mainly in the biological processes of cytokine and cell secretion, which may be associated with radiation-induced enteritis [37]. Some researchers have compared inflammatory bowel disease and normal segments of colon from patients with radiation proctitis against normal controls and found that radiation-induced tissue damage is associated with elevated levels of interleukins, especially interleukin-1β [38].…”

Section: Discussionmentioning

confidence: 99%

Identification of Circular RNAs Altered in Mouse Jejuna After Radiation

Lu¹,

Gong²,

Wang³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circular RNAs (circRNAs) make up a large class of non-coding RNAs and play important roles in a variety of diseases, including nervous system diseases and cancers. The intestinal epithelium is sensitive to ionizing radiation, radiotherapy of abdominal or pelvic tumors or nuclear accident exposure can lead to high radiation toxicity, which can result in radiation-induced intestinal injury. The goal of this present study was to analyze the potential roles of circRNAs in radiation-induced intestinal injury. Methods: Mice were divided into two groups: control group and irradiated group. Irradiated group was 3.5 days after 14Gy abdominal irradiation (ABI) group. We started with RNA-seq of circRNA changes in mouse jejuna after radiation and validated by RT-PCR in the following experimental. miRNAs targeted mRNAs were predicted using proprietary software based on target scan and Miranda. The network of circRNA-miRNA-mRNA was illustrated by cytoscape software. Results: 2751 circRNAs were detected in the two groups. At day 3.5 post-radiation, 42 and 48 circRNAs were found to be significantly upregulated and downregulated, respectively, compared to the control (p≤0.05, Fold Change ≥2). Further, the altered expression of 10 circRNAs (chr18: 35610871-35613502+, chr15: 95864225-95894541+, chr3: 96041338-96042928-, chr5: 64096979-64108263+, chr19: 16705875-16710941-, chr5: 134491893-134500149-, chr19: 42562552-42564341+, chr5: 32640331-32664400+, chr3: 72958113-72960367- and chr8: 79343654-79372364-) were verified by RT-PCR. Compared the miRNA-targeted mRNAs with our mRNAs sequencing data, we found 14 upregulated circRNA-targeted mRNAs were also unregulated and 22 downregulated circRNAs-targeted mRNAs were also downregulated. Gene ontology and KEGG pathway analyses indicated the predicted genes were mainly involved in the MAPK signaling pathway. Conclusions: This study reveals that expression of circRNAs was altered in the jejuna of mice post-irradiation and provides a resource for the study of circRNAs in radiation-induced intestinal injury and repair.

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Section: Discussionmentioning

confidence: 99%

Identification of Circular RNAs Altered in Mouse Jejuna After Radiation

Lu¹,

Gong²,

Wang³

et al. 2018

Cell Physiol Biochem

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“…There is no concrete evidence to suggest that higher quantities of antioxidants are beneficial. 8 Treatment depends on the pattern of the symptoms involved. Controlling diarrhoea involves use of anti-diarrhoeal agents such as loperamide 9 and, if ongoing, the addition of bile acid sequestrants can be helpful.…”

Section: Radiotherapy-related Enteritismentioning

confidence: 99%

Gastrointestinal side effects of cancer treatments

O’Reilly

Mellotte

Ryan

et al. 2020

Therapeutic Advances in Chronic Disease

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Cancer survival rates have significantly improved over the last number of years due to advancements in cancer therapies. Unfortunately this has come at a cost. Therapeutic side effects are feared complications of therapy that may result in decreased quality of life and early cessation of the therapy, which can have knock-on effects on outcomes. This article outlines the main gastrointestinal side effects seen with radiation therapy, chemotherapy and immunotherapy, and discusses appropriate investigation and management.

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“…Ninety percent of patients present with ARII, and subsequently, 5% to 55% develop CRII post-pelvic radiotherapy. [6][7][8] Most of the symptoms of ARII are transient, self-healing, and relieved within 3 months. While CRII often emerges 12~24 months after the end of radiotherapy, it is progressive and difficult to reverse.…”

Section: Introductionmentioning

confidence: 99%

Risk Prediction and Treatment of LE-DVT in Patients with Chronic Radiation Intestinal Injury: A Retrospective Case–Control Study

Huang

Kuang

Qin

et al. 2021

CMAR

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Background Chronic radiation intestinal injury (CRII) is the most common complication after pelvic malignancy radiation. Once hemorrhagic CRII patients suffer from lower extremity deep venous thrombosis (LE-DVT), hemostasis and anticoagulation therapy will be adopted simultaneously, but the treatment strategy is a paradox, as the condition is extremely intractable and serious. The aim of this study was to investigate the prevalence of and risk factors for LE-DVT in CRII patients and explore the treatment of hemorrhagic CRII patients with LE-DVT. Methods This was a retrospective study, and a total of 608 hospitalized CRII patients after pelvic radiotherapy were included from November 2011 to October 2018. Univariate and multivariate analyses were conducted to investigate the potential risk factors for LE-DVT in CRII patients. Furthermore, the treatment of hemorrhagic CRII patients with LE-DVT was explored. Results Among the CRII patients, 94 (15.5%) were with suspicious symptoms of LE-DVT in the lower limbs, and 32 (5.3%) were diagnosed with LE-DVT. Among the patients with LE-DVT, 65.6% (21/32) had bleeding simultaneously, and 29 (90.6%) had anemia with 24 (75.0%) having moderate to severe anemia. Multivariate analysis showed that a recent surgical history (≤6 months) (OR = 5.761, 95% CI: 2.506~13.246, p < 0.001), tumor recurrence or metastasis (OR = 3.049, 95% CI: 1.398~6.648, p = 0.005) and the hemoglobin (Hb) level (OR = 0.960, 95% CI: 0.942~0.979, p < 0.001) were significantly associated with the development of LE-DVT. ROC curve analysis showed that the AUC of the merged risk score of the independent risk factors was 0.822 (95% CI: 0.789~0.852), and the optimal Hb cutoff was 82.5 g/L. After colostomy, obvious bleeding remission was rapidly found in 84.6% of hemorrhagic CRII patients with LE-DVT. Conclusion The prevalence of LE-DVT in hospitalized CRII patients was 5.3%. A recent surgical history, tumor recurrence or metastasis and a lower Hb level were independently associated with LE-DVT development in CRII patients. Colostomy could be a good choice for intractable hemorrhagic CRII patients with LE-DVT.

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Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis

Cited by 15 publications

References 127 publications

Identification of Circular RNAs Altered in Mouse Jejuna After Radiation

Identification of Circular RNAs Altered in Mouse Jejuna After Radiation

Gastrointestinal side effects of cancer treatments

Risk Prediction and Treatment of LE-DVT in Patients with Chronic Radiation Intestinal Injury: A Retrospective Case–Control Study

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