Antioxidant stilbenoid and flavanonol from stem of <i>Erythrophleum suaveolens</i> (Guill. &amp; Perr.)

Ngoupayo, Joseph; Tabopda, Turibio Kuiate; Ali, Muhammad; Ngadjui, Bonaventure T.; Lacaille‐Dubois, Marie‐Aleth

doi:10.1002/mrc.4253

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…The cold water crude extract of the stem bark has the potential of been developed as an antimotility agent as a remedy for gastrointestinal problems (Ogundeko et al, 2014). Ngoupayo et al (2015) reported the antioxidant activity of stibenoid and flavononol isolated from the stem of E. suaveolens.…”

Section: Erythrophleum Suaveolens (Guill and Perr) Brenan -Fabaceaementioning

confidence: 99%

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Gbadamosi¹,

Erinoso²

2016

Afr. J. Pharm. Pharmacol.

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Breast cancer is the leading malignancy in the South Western Nigeria; it is second to cancer of the cervix in the northwest. In north-central, 22.41% of new cancer was registered for breast cancer in five years and accounted for 35.41% of all cancers in women. The limitations of orthodox drugs such as cost, accessibility, effectiveness, and side effects necessitate the search for cheap, safe and effective phytomedicine in cancer management. Thus, this paper reviewed twenty plants used traditionally for the management of breast cancer; this was with a view to presenting them for future research activities and scientific validation of their potency in cancer regimen.

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Section: Erythrophleum Suaveolens (Guill and Perr) Brenan -Fabaceaementioning

confidence: 99%

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Gbadamosi¹,

Erinoso²

2016

Afr. J. Pharm. Pharmacol.

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“…This plant is used for the improvement of blood circulation in Chinese oriental medicine [24]. Various chemicals are derived from Erythrophleum fordii, such as cassaine ditetpenoids, diterpenes, triterpenoids, and flavanonol [25][26][27][28]. C5 is one of the natural extracts of Erythrophleum fordii and one form of cassaine diterpene alkaloid, also known as 3β-acetyl-nor-erythrophlamide [29].…”

Section: Discussionmentioning

confidence: 99%

C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells

Kim

Seo

Kim

et al. 2020

IJMS

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Apoptosis pathways in cells are classified into two pathways: the extrinsic pathway, mediated by binding of the ligand to a death receptor and the intrinsic pathway, mediated by mitochondria. Apoptosis is regulated by various proteins such as Bcl-2 (B-cell lymphoma 2) family and cellular FLICE (Fas-associated Death Domain Protein Interleukin-1β-converting enzyme)-inhibitory protein (c-FLIP), which have been reported to inhibit caspase-8 activity. In this study, it was found that C5 (3β-Acetyl-nor-erythrophlamide), a compound of cassaine diterpene amine from Erythrophleum fordii, induced cell apoptosis in a variety of types of cancer cells. Induction of apoptosis in cancer cells by C5 was inversely related to the level of Bcl-2 expression. Overexpression of Bcl-2 into cancer cells significantly decreased C5-induced apoptosis. It was also found that treatment of cancer cells with a caspase-8 inhibitor significantly suppressed C5-induced apoptosis; however, treatment with caspase-9 inhibitors did not affect C5-induced apoptosis, suggesting that C5 may induce apoptosis via the extrinsic pathway by activating caspase-8. It was confirmed that treatment with C5 alone induced an association of FADD with procaspase-8; however, overexpression of c-FLIP decreased C5-induced caspase-8 activation. In conclusion, C5 could be utilized as a new useful lead compound for the development of an anti-cancer agent that has the goal of apoptosis.

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“…Lan et al [34] summarized 33 stilbene compounds, i.e., Caragan, resveratrol (63), [35] piceatannol (64), [24] isorhpontigenin (65), [24] pinosylvin (66), [36] 2-(4-hydroxyphenytacetyl)-4methoxy-6-hydroxy benzoic acid (67), [35] cassigarol E (68), cassigarol G (69), maackin (70), cararosinol C-D (71-72), cis-scirpusin A (73), scirpusin A-B (74-75), [24] pallidol (76), [35] kompasinol A (77), [24] caragasinin A (78), [37] caragasinin B, miyabenol C, leachianol C, kobophenol A, carasiphenol D (79-83), [38] (+)-α-viniferin, carasiphenol B, and carasiphenol C (84-86), [39] (+)-stenophyllol B, carasinols A-C, carasinol D, carasinasurone, carasiphenol A (87-93), [35] cararosinol B (94), [40] cararosin (95). [41] Ngoupayo et al [42] reported the isolation and structure elucidation of compounds from the stems of Erythrophleum suaveolens, including a new stilbenoid, suaveolensone A (96). Nguyen et al [43] isolated a new stilbenoid (97) from the soluble extract of EtOAc from the root bark of Erythrina addisoniae.…”

Section: Stilbenes Isolated From Leguminosaementioning

confidence: 99%

Stilbenoids from Leguminosae and their Bioactivities

Lei¹,

Zhou²,

Li³

et al. 2019

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Stilbenoids, usually found in Leguminosae, are a class of compounds with the skeleton of stilbene or their polymers, existing mostly in the xylem of plants. Till now, one hundred and seventy-six stilbenoids have been isolated from plants of Leguminosae. Herein, stilbene compounds and their derivatives in Leguminosae and their biological activities including anti-neoplastic, anti-bacterial, anti-inflammation are reviewed.

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Antioxidant stilbenoid and flavanonol from stem of Erythrophleum suaveolens (Guill. & Perr.)

Cited by 9 publications

References 16 publications

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells

Stilbenoids from Leguminosae and their Bioactivities

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