Antioxidant Status of Neonates Exposed in utero to Tobacco Smoke

Fayol, L; Gulian, Jean-Marc; Dalmasso, Cyril; Calaf, R.; Simeoni, Umberto; Millet, V.

doi:10.1159/000082128

Cited by 29 publications

(36 citation statements)

References 68 publications

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“…Our data showed that the extent of maternal exposure to environmental tobacco had a significant effect on maternal, but not neonatal, serum vitamin A concentration, which is consistent with previous reports (31,32). The different effect of environmental tobacco smoke on maternal and neonate vitamin A status was probably related to the efficient buffering function of the placenta.…”

Section: Relationship Between Maternal and Cord Vitamins A E And Csupporting

confidence: 92%

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Wang

Ren

Liao

et al. 2009

J Nutr Sci Vitaminol

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Summary Background: Emerging evidence indicates that maternal oxidative stress during pregnancy could impair fetal growth and that antioxidant vitamins (e.g. vitamins A, E and C) have a significant role in miantaining physiological processes of pregnancy and growth. Aims: To determine the concentrations of vitamins A, E, and C in pair-matched maternal and cord serum samples of neonate, and thus to investigate the relationship between maternal serum levels of these vitamins at delivery and birth outcomes. Methods: A total of 143 mother-neonate pairs were recruited into the cross-sectional descriptive study. Demographic information was investigated by questionnaire. After delivery, both cord and maternal blood were collected for quantification of serum levels of vitamins A, E and C by HPLC. Results: Maternal serum levels of vitamins A and E were significantly higher than those in cord serum. In contrast, vitamin C level in cord serum was significantly higher than that in maternal serum. Further, we found that maternal vitamin A status was significantly correlated to both birth weight ( r ϭ 0.19, p ϭ 0.0419) and birth height ( r ϭ 0.21, p ϭ 0.0311), and these were manifested by these findings: (i) per 250.2 g reduction in birth weight concomitant with 1 mol/L increase in maternal serum vitamin A level ( p Ͻ 0.01; 95% CI: 56.9-451.5); and (ii) per 1% increase in the ratio of serum vitamin A level of neonate to mother concomitant with 0.8 cm increase in birth height ( p ϭ 0.049; 95% CI: 0.004-1.639). Conclusion: Maternal vitamin A, but not vitamins E and C, during pregnancy had a significant effect on birth outcomes. Further studies are necessary to investigate the role of these antioxidant vitamins in fetal growth at various gestation stages.

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Section: Relationship Between Maternal and Cord Vitamins A E And Csupporting

confidence: 92%

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Wang

Ren

Liao

et al. 2009

J Nutr Sci Vitaminol

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“…Recent reports demonstrated an increase in haemeoxygenase 1 and 2 expressions in the placenta of smoking mothers, and increased levels of ceruloplasmin in the plasma of newborns and mothers exposed to tobacco smoking. 16,17 These molecules are known as antioxidants that might reduce oxidative stress in the ischemic retina of premature infants, which might inhibit the excessive expression of angiogenic factors.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of maternal smoking on the development of severe retinopathy of prematurity

Hirabayashi

Honda

Morioka

et al. 2009

Eye

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Purpose In this study, the effects of maternal smoking along with other clinical risk factors in developing severe retinopathy of prematurity (ROP) were evaluated. Design A case-control study. Methods Records of newborn infants with an estimated postmenstrual age of 32 weeks or less (n ¼ 86) were reviewed. ROP grading was evaluated in accordance with the International Classification of Retinopathy of Prematurity. Severe ROP was diagnosed when it progressed to stage 3 with plus disease. The factors were first evaluated using a univariate logistic regression analysis between the groups of severe and non-severe ROP, followed by a multivariate logistic regression analysis using STATA version 10 and R version 2.71. Results A low birth weight, a long duration of artificial ventilation and oxygen supplementation, presence of chronic lung disease, and absence of maternal smoking were found to be significantly associated with severe ROP in the univariate logistic regression analysis. In the multivariate logistic regression analysis, maternal smoking was revealed as a significant factor independently associated with the incidence of severe ROP. Conclusions An inhibitory effect of maternal smoking against developing severe ROP is suggested. The mechanism by which smoking may reduce the incidence of severe ROP needs to be further investigated.

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“…Animal research demonstrates that environmental, or passive smoke exposure, affects fetal brain development in the same manner as exposure through direct maternal routes [23]. In humans, second hand smoke exposure during pregnancy results in the same degree of negative pregnancy outcomes as direct maternal use, including genotoxic effects [24], decreased fertility [25], neonatal antioxidant status [26], and increased fetal mortality, preterm births, and reduced fetal growth [27,28,29]. Given that nicotine exposure affects neural development at doses lower than those required to affect physical growth, the finding that birth weight and other physical correlates of nicotine exposure are impacted in fetuses whose mothers were passively exposed to smoke suggests that CNS correlates are likely to be implicated.…”

Section: Introductionmentioning

confidence: 99%

Direct and Passive Prenatal Nicotine Exposure and the Development of Externalizing Psychopathology

Gatzke‐Kopp

Beauchaine

2007

Child Psychiatry Hum Dev

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The association between maternal smoking during pregnancy and childhood antisocial outcomes has been demonstrated repeatedly across a variety of outcomes. Yet debate continues as to whether this association reflects a direct programming effect of nicotine on fetal brain development, or a phenotypic indicator of heritable liability passed from mother to child. In the current study, we examine relations between maternal smoking and child behavior among 133 women and their 7-15-year-olds, who were recruited for clinical levels of psychopathology. In order to disentangle correlates of maternal smoking, women who smoked during pregnancy were compared with (a) those who did not smoke, and (b) those who did not smoke but experienced significant second-hand exposure. Second-hand exposure was associated with increased externalizing psychopathology in participant mothers' offspring. Moreover, regression analyses indicated that smoke exposure during pregnancy predicted conduct disorder symptoms, over and above the effects of income, parental antisocial tendencies, prematurity, birth weight, and poor parenting practices. This is the first study to extend the findings of externalizing vulnerability to second hand smoke exposure.

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Antioxidant Status of Neonates Exposed in utero to Tobacco Smoke

Cited by 29 publications

References 68 publications

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Inhibitory effects of maternal smoking on the development of severe retinopathy of prematurity

Direct and Passive Prenatal Nicotine Exposure and the Development of Externalizing Psychopathology

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