Antioxidant status in patients with acute respiratory distress syndrome

Metnitz, Philipp; Bartens, C.; Fischer, M; Fridrich, Peter; Steltzer, H.; Druml, Wilfred

doi:10.1007/s001340050813

Cited by 247 publications

(175 citation statements)

References 21 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…Extensive literatures have boasted the essential role of oxidative stress in the development of OA-induced ALI. [38][39][40][41] Intravenous administration of OA could produce neutrophil activation as well as endothelium damage, resulting in abundant ROS generation and decreased activity or protein expression of SOD and catalase probably through downregulation of NADPH oxidase-dependent pathway or upregulation of NF-kB phosphorylation at p65. [42][43][44][45] Thus, we designed in vitro and in vivo experiments to investigate the possible impact of SO 2 pathway on lung tissue oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats

Chen

Zheng

Liu

et al. 2015

Laboratory Investigation

View full text Add to dashboard Cite

The role of endogenous sulfur dioxide (SO 2 ), an efficient gasotransmitter maintaining homeostasis, in the development of acute lung injury (ALI) remains unidentified. We aimed to investigate the role of endogenous SO 2 in the pathogenesis of ALI. An oleic acid (OA)-induced ALI rat model was established. Endogenous SO 2 levels, lung injury, oxidative stress markers and apoptosis were examined. OA-induced ALI rats showed a markedly downregulated endogenous SO 2 /aspartate aminotransferase 1 (AAT1)/AAT2 pathway and severe lung injury. Chemical colorimetry assays demonstrated upregulated reactive oxygen species generation and downregulated antioxidant capacity in OA-induced ALI rats. However, SO 2 increased endogenous SO 2 levels, protected against oxidative stress and alleviated ALI. Moreover, compared with OA-treated cells, in human alveolar epithelial cells SO 2 downregulated O 2 À and OH À generation. In contrast, L-aspartic acid-b-hydroxamate (HDX, Sigma-Aldrich Corporation), an inhibitor of endogenous SO 2 generating enzyme, promoted free radical generation, upregulated poly (ADP-ribose) polymerase expression, activated caspase-3, as well as promoted cell apoptosis. Importantly, apoptosis could be inhibited by the free radical scavengers glutathione (GSH) and N-acetyl-L-cysteine (NAC). The results suggest that SO 2 /AAT1/AAT2 pathway might protect against the development of OA-induced ALI by inhibiting oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats

Chen

Zheng

Liu

et al. 2015

Laboratory Investigation

View full text Add to dashboard Cite

show abstract

“…Previous research has established that ARDS increases oxidative stress and secretion of ROS from the neutrophils of patients (25)(26)(27)(28)(29)(30). Studies involving the experimental induction of ALI as a model for ARDS have reported increased MDA concentration, indicating increased oxidative stress and altered activity of antioxidant enzymes (15,(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

“…Studies involving the experimental induction of ALI as a model for ARDS have reported increased MDA concentration, indicating increased oxidative stress and altered activity of antioxidant enzymes (15,(31)(32)(33). Additional research has revealed that the plasma of patients with ARDS contains reduced levels of antioxidants and that neutrophil infiltration and ROS accumulation can exhaust the total antioxidant capability of the lungs (26,30).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Rats

et al. 2013

View full text Add to dashboard Cite

Background: Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI).Aims: The aim of this study was to investigate the possible protective role of alpha-lipoic acid (α-LA) on oleic acid (OA)-induced ALI in rats.Study Design: Animal experiment.Methods: A total of thirty-five rats were divided into five groups in the study. Group 1 served as a control group. Rats in Group 2 (α-LA) were administered α-LA intraperitoneally at a dose of 100 mg/kg body weight (BW). Rats in Group 3 (OA) were administered OA intravenously at a dose of 100 mg/kg BW. In Group 4 (pre-OA-α-LA), α-LA was given 15 minutes prior to OA infusion, and in Group 5 (post-OA-α-LA), α-LA was given two hours after OA infusion. Four hours after the OA infusion, rats were decapitated. Blood samples were collected to measure serum levels of malondialdehyde (MDA) and glutathione (GSH), and the levels of activity for superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Lung tissue samples were taken for histopathological examination.Results: Exposure to OA resulted in increases in serum MDA levels (p<0.001), as well as histopathological lesions in lung tissue, and decreases in CAT (p<0.05), GSH-Px (p<0.05) activities and GSH (p<0.05) levels. On the other hand, MDA levels were decreased significantly (p<0.001), while CAT (p<0.05), GSH-Px (p<0.01) activities and GSH (p<0.05) levels were increased significantly in the pre-OA-α-LA group compared with the OA group.Conclusion: α-LA was found to lessen oxidative stress and to have positive effects on antioxidants in cases of OA-induced ALI. In conclusion, α-LA appears to have protective effects against ALI and potential for the prevention of ALI.

show abstract

“…Plasma antioxidant levels decreased in patients with ARDS. Free oxygen radicals and neutrophile streams are thought to consume the total antioxidant capacity of lungs (3,4).…”

Section: Effects Of Lycopene On the Model Of Oleic Acid-induced Acutementioning

confidence: 99%

Effects of lycopene on the model of oleic acid-induced acute lung injury

Türkoğlu¹,

Muz²,

Ozercan³

et al. 2012

Tuberk Toraks

View full text Add to dashboard Cite

show abstract

Antioxidant status in patients with acute respiratory distress syndrome

Cited by 247 publications

References 21 publications

Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats

Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats

Protective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Rats

Effects of lycopene on the model of oleic acid-induced acute lung injury

Contact Info

Product

Resources

About