Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease

Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study

“…The activity of GPx depends on the availability of GSH and selenium, the depletion of which was reported in celiac patients. 13,26,27 It appears that a reduction in GSH and selenium levels is followed by a decrease in GPx activity.…”

“…In subsequent papers, the same authors reported that GPx activity in the small intestine was also significantly lower in children with untreated and silent CD than in controls, and they showed a positive correlation between GPx activity and both GR and GSH concentrations. 13,27 To the best of our knowledge, no previous research has investigated serum GPx3 levels in adult celiac patients. In agreement with the above data, our results demonstrated a decreased activity of this antioxidant enzyme in the celiac group when compared with controls.…”

Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients

“…Several studies have shown that ROS and oxidative stress are strongly associated with the celiac disease (Dugas et al 2003, Maiuri et al 2003. In our previous papers we investigated the AO status of children affected by the celiac disease (Stojiljković et al 2007(Stojiljković et al , 2009). Since GSH is a main detoxifier of endogenous and exogenous ROS in intestine (LeGrand and Aw 2001), in this study we focused on the role of glutathione redox cycle in celiac patients.…”

Antioxidant status of the celiac mucosa: implications for disease pathogenesis

“…Odetti et al (1998) found a lowered level of vitamin E and increased levels of markers of oxidized lipids and proteins in the plasma of celiac patients subjected to gluten free diet, while Ståhlberg et al have reported decreased GSH concentrations and GPx activity in erythrocytes and the small intestinal mucosa of children affected by celiac disease (Ståhlberg et al, 1988;Ståhlberg & Hietanen, 1991). In our previous papers (Stojiljković et al, 2007;Stojiljković et al, 2009) we showed that oxidative stress is strongly associated with CD and that the AO capacity of celiac patients is weakened by a depletion of GSH and reduced activities of GSHdependent AO enzymes GPx and GR. In this study we describe the results of our investigation regarding the AO status of celiac patients with different degrees of severity of the mucosal lesion.…”