Antioxidant stability enhancement of carotenoid rich-extract from Cantaloupe melon (Cucumis melo L.) nanoencapsulated in gelatin under different storage conditions

Nanoparticles Loaded with a Carotenoid-Rich Extract from Cantaloupe Melon Improved Hepatic Retinol Levels in a Diet-Induced Obesity Preclinical Model

“…The evaluated contents may vary depending on the degree of maturation, soil type, growing conditions, climatic conditions, plant variety, and exposure to sunlight . Therefore, the results were observed to approximate the levels found in previous studies, , reinforcing that CE from cantaloupe melon pulp is an essential plant source of carotenoids, emphasizing beta-carotene as a precursor of vitamin A …”

“…Nanoparticles containing the crude extract rich in carotenoids from the cantaloupe melon pulp in porcine gelatin (EPG) have already been produced by Medeiros et al and Oliveira et al In this study, EPG showed the same physicochemical characteristics and incorporation efficiency of carotenoids demonstrated by Medeiros et al, Medeiros et al, and Oliveira et al even with the obtainment of new batches, which effectively contributed to the investigations in the present study. These findings showed that the replicated method used in this study achieved the desired characteristics, overcoming the difficulties related to reproducibility in obtaining nanoparticles.…”

“…Carotenoids from the most diverse sources are essential precursors of vitamin A (β-carotene, α-carotene, and β-cryptoxanthin), which are determined by absorption (bioavailability) and subsequent conversion to retinol (bioconversion) . Medeiros et al, Medeiros et al, and Oliveira et al demonstrated in their studies that the extract of the cantaloupe melon pulp is an abundant source of beta-carotene. The present study verified the content of total carotenoids of 51.1 μg/g of fresh cantaloupe melon pulp.…”

Nanoencapsulation of buriti oil (Mauritia flexuosa L.f.) in porcine gelatin enhances the antioxidant potential and improves the effect on the antibiotic activity modulation

“…The ability to scavenge the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS•) radical cation was determined by adapting the methodology described by Rufino et al [28]. The ABTS• solution was prepared by adding ABTS• (7 mM) and potassium persulfate (2.45 mM) and incubated at room temperature in the dark for 16 h. Next, the ABTS solution (1 mL) was diluted in DMSO to obtain an absorbance of 0.8, at a wavelength of 734 nm [29,30]. Finally, 200 μL of this ABTS• radical solution was carefully added to the microplate well together with 40 μL of the evaluated samples.…”

“…According to the Eqs 5, 6 and 7 below, the fractional inhibitory concentration index (FICi) measurement was determined to demonstrate the synergistic effect. The FICi index was interpreted according to the European Committee for Antimicrobial Susceptibility Testing (30), considering the synergistic effect FICi � 0.5 [33].…”