Antioxidant role of zinc in PCB (Aroclor 1254) exposed ventral prostate of albino rats

Venkataraman, P.; Sridhar, M.; Dhanammal, Siva; Vijayababu, M.R.; Srinivasan, Narasimhan; Arunakaran, J.

doi:10.1016/j.jnutbio.2004.06.001

Cited by 31 publications

(25 citation statements)

References 35 publications

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“…SOD, GSH, CAT, and MDA are the marks for oxidative stress because they are involved in the antioxidant defense system leading to potential damage due to oxidative stress [30][31][32]. In this experiment, supplementation with 90 mg/kg Zn-Gly increased the activity of Cu/Zn-SOD and GSH-P X and lowered the level of MDA in livers of 21-day broilers.…”

Section: Discussionmentioning

confidence: 77%

Effects of Zinc Glycine Chelate on Oxidative Stress, Contents of Trace Elements, and Intestinal Morphology in Broilers

Niu

Feng

et al. 2010

Biol Trace Elem Res

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Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1) control (containing 29.3 mg zinc (Zn)/kg basic diet (0-21 days) and 27.8 mg Zn/kg (22-42 days)); (2) basic diet plus 30 mg Zn/kg from Zn-Gly; (3) basic diet plus 60 mg Zn/kg from Zn-Gly; (4) basic diet plus 90 mg Zn/kg from Zn-Gly; (5) basic diet plus 120 mg Zn/kg from Zn-Gly; and (6) positive control, basic diet plus 120 mg Zn/kg from zinc sulfate (ZnSO(4)). The results showed that the addition of 90 or 120 mg/kg Zn-Gly led to an improvement of activity of Cu/Zn superoxide dismutase and glutathione peroxidase and a reduction of malondialdehyde content in livers at 21 and 42 days. With 90 mg/kg Zn-Gly, the content of sera zinc increased by 17.55% (P < 0.05) in 21-day broilers and 10.77% (P > 0.05) in 42-day broilers compared with that of the control. Adding 120 mg/kg Zn-Gly or ZnSO(4) to broilers' diets greatly enhanced the content of zinc in feces at 21 days (P < 0.05) and at 42 days (P < 0.05). For 42-day chickens, increased villus height and decreased crypt depth of the jejunum could be observed in the second growth stage of broilers fed with 90 mg/kg Zn-Gly. Also, intestinal wall thickness decreased (P < 0.05). In addition, adding 90 mg/kg Zn-Gly to the diet markedly elevated villus length of duodenum and decreased crypt depth of ileum (P < 0.05) in 42-day broilers.

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Section: Discussionmentioning

confidence: 77%

Effects of Zinc Glycine Chelate on Oxidative Stress, Contents of Trace Elements, and Intestinal Morphology in Broilers

Niu

Feng

et al. 2010

Biol Trace Elem Res

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“…Dietary flavonoids such as catechins (epigallocatechin gallate) and quercetin can inhibit the toxic effects of environmental contaminants such as PCB at both functional levels of AhR and/or CYP1A1 [55]. PCB (Aroclor 1254) induces oxidative stress in ventral prostate of the rat by decreasing the levels of antioxidant enzymes, which could be effectively reversed by zinc supplementation, presumably via a mechanism of indirect hormonal regulation [56].…”

Section: Pcb Lipids and Oxidative Stressmentioning

confidence: 99%

Dietary PUFA and flavonoids as deterrents for environmental pollutants

Watkins

Hannon

Ferruzzi

et al. 2007

The Journal of Nutritional Biochemistry

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“…These antioxidants include a family of glutathione (GSH)-dependent enzymes, superoxide dismutase (SOD, EC 1.15.1.1), and catalase (CAT, EC 1.11.1.6) [9] . SOD is a copper-and zinccontaining enzyme and constitutes the first line of defense against superoxide anion-mediated injury [10] . SOD converts superoxide anion into hydrogen peroxide (H 2 O 2 ) and oxygen.…”

Section: Introductionmentioning

confidence: 99%

Effects of Zinc on Hepatic Antioxidant Systems and the mRNA Expression Levels Assayed by cDNA Microarrays in Rats

Jing¹,

Sun²,

Zi³

et al. 2007

Ann Nutr Metab

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Background: This study evaluated effects of zinc on the hepatic lipid peroxidation, antioxidant components and mRNA expression levels in rats. Methods: Three diets with different Zn levels including Zn adequacy (ZA; 34.50 mg/kg, control), Zn deficiency (ZD; 3.30 mg/kg), and Zn overdose (ZO; 345.45 mg/kg) were fed to rats for 6 weeks. The mRNA expression levels were analyzed by cDNA microarrays. Results: The body weight of rats fed the ZD diet was less (p < 0.01) than that of rats fed the ZA diet. Zn overdose elevated body weight, but the increase was not detected (p > 0.05) at week 6. Although copper and iron status in serum were declined (p < 0.01), those in liver were not affected (p > 0.05) by the high intake of zinc. The glutathione peroxidase (GPx) and glutathione (GSH) remained unchanged (p > 0.05) by zinc treatment. Rats fed the ZD diet showed reductions(p < 0.01) in the Cu-Zn superoxide dismutase (Cu-Zn SOD) and catalase (CAT) activity, and increases (p < 0.01) in the malondialdehyde and hydrogen peroxide (H₂O₂) contents. Rats fed the ZO diet particularly had higher Cu-Zn SOD (p < 0.01) activity. The mRNA expression levels of SOD were upregulated in the ZO group, and CAT was downregulated in the ZD group, while no changes in GPx mRNA levels were found after zinc treatment. Conclusion: The study suggested that zinc deficiency largely decreased body weight; zinc overdose, however, moderately stimulated growth in the early growing phase of rats. High dietary zinc did not compete with liver copper and iron status. Although Zn deficiency impaired antioxidant functions, zinc overdose hardly enhanced the antioxidant systems of animals.

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Antioxidant role of zinc in PCB (Aroclor 1254) exposed ventral prostate of albino rats

Cited by 31 publications

References 35 publications

Effects of Zinc Glycine Chelate on Oxidative Stress, Contents of Trace Elements, and Intestinal Morphology in Broilers

Effects of Zinc Glycine Chelate on Oxidative Stress, Contents of Trace Elements, and Intestinal Morphology in Broilers

Dietary PUFA and flavonoids as deterrents for environmental pollutants

Effects of Zinc on Hepatic Antioxidant Systems and the mRNA Expression Levels Assayed by cDNA Microarrays in Rats

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