Antioxidant role of Umbelliferone in STZ-diabetic rats

Ramesh, B.; Pugalendi, Kodukkur Viswanathan

doi:10.1016/j.lfs.2006.01.005

Cited by 105 publications

(63 citation statements)

References 33 publications

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“…STZ was dissolved in freshly prepared ice-cold sodium citrate buffer (0.1 mol/L, pH 4.5) and injected intraperitoneally. 19 The SHR group of rats (II) received an equal amount of buffer intraperitoneally. After 3 days, a drop of blood was obtained by nicking the tail of overnight fasted rats and glucose concentrations were obtained using glucometer (GlucoSure plus, Apex Biotechnology Corp., Hsinchu, Taiwan) to determine the extent of hyperglycemia.…”

Section: Experimental Protocolmentioning

confidence: 99%

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

et al. 2012

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The coexistence of hypertension and diabetes results in the rapid development of nephropathy. Hydrogen sulfide (H 2 S) is claimed to control the vascular and renal functions. This study tested the hypothesis that exogenous H 2 S lowers the blood pressure and decreases the progression of nephropathy in spontaneously hypertensive rats (SHR) that were diabetic. Eighteen SHR were divided into three groups: SHR, SHR diabetic, and SHR diabetic treated with a group of Wistar-Kyoto rats serving as normotensive nondiabetic control. Diabetes was induced with streptozotocin (STZ) in two groups and one diabetic group received sodium hydrosulfide (NaHS), a H 2 S donor for 5 weeks. Blood pressure was measured in conscious and anesthetized states and renal cortical blood perfusion in acute studies. Plasma and urinary H 2 S levels, creatinine concentrations, and electrolytes were measured on three different occasions throughout the 35-day period. Diabetic SHR had higher blood pressure, lower plasma and urinary H 2 S levels, and renal dysfunction as evidenced by increased plasma creatinine, creatinine clearance, and decreased urinary sodium-to-potassium ratio and renal cortical blood perfusion. NaHS reduced blood pressure, increased H 2 S levels in plasma and urinary excretion, and reversed the STZ-induced renal dysfunction. The findings of this study suggest that the administration of exogenous H 2 S lowers the blood pressure and confers protection against the progression of STZ-induced nephropathy in SHR.

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Section: Experimental Protocolmentioning

confidence: 99%

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

et al. 2012

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“…The marked hyperlipidemia that characterizes the diabetic state may, therefore, be regarded as a consequence of uninhibited actions of lipolytic hormones on the fat deposits. [15] Studies on STZ-induced diabetes in experimental animals have suggested that an increase in circulatory VLDL and their associated TG are largely due to defective clearance of these particles from the circulation. [16] Normally, circulating LDL-C undergoes reuptake in the liver through specific receptors and gets cleared from the circulation.…”

Section: Discussionmentioning

confidence: 99%

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Singh¹

2017

IJGP

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Background: Ficus racemosa Linn. (FR) is commonly known as gula fig/cluster fig.It is moderate sized avenue tree found throughout India either wild or cultivated for its fruits eaten by villagers. Objective: The main aim of the study was to evaluate the antidiabetic potential of various polar and non-polar extracts of leaves and bark of FR in animals. Materials and Methods: The crude drugs were extracted using various polar and non-polar solvents and preliminary phytochemical screening was performed for the presence of various phytocompounds. Diabetes was induced by a single I.P. injection of streptozotocin in normal control animals and treatment of different polar and non-polar extracts of leaves and bark of FR in diabetic animals. Blood glucose levels and various lipid parameters were evaluated in normal, diabetic, and various drug-treated animals. Results: In 21-day, glibenclamide as standard drug restored the blood glucose level and it is highly significantly(P < 0.001) in 14 days, where as methanolic extracts of FR (200 and 400 mg/kg) reduced the glucose level moderately and highly significant (P < 0.001). Petroleum ether, chloroform, ethyl acetate, and ethanolic extracts of FR had moderately significant effects (P < 0.01) on 14 th and 21 st days. Conclusion: This study reveals that methanolic extract of the plant is more effective in both cause of potential evaluation. In future, this plant can be used as antidiabetic and hypolipidemic drug for developing new pharmaceuticals and treatment of several diseases.

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“…The decrease in these enzymes activity in diabetic rats given clove shows that this spice presented liver damage (Hassanen, 2010). In addition, Ramesh and Pugalendi (2006) reported that treatment of diabetic rats with spices or their essential oils recovered the membrane damage by decreasing lipid peroxidation and improving anti-oxidants' status .…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

2011

Egypt. J. Rad.Sci.

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IABETES is characterized by hyperglycaemia and elevated production of reactive oxygen species (ROS). Clove is full of natural antioxidants such as polyphenols and essential oils. The aim of the study was to investigate the hypoglycaemic effect of clove extract in diabetic rats.The results with test rats indicated that alloxan administration induced the elevation of glucose level, activity of some liver enzymes, malondialdehyde (MDA), urea and creatinine concentrations as well as the level of some lipid contents.While the level of insulin, total thyroid hormones triiodothyronin (T 3 ) and thyroxine (T 4 ), glutathione content (GSH) in addition to the concentration of high density lipoprotein (HDL-C) were decreased under the effect of alloxan.As a result of treatment of diabetic rats with raw or irradiated clove extract, hyperglycaemia, hepatic, renal and endocrine abnormalities induced by alloxan were improved.Conclusion: clove extract exerts a dietary antidiabetic benefit and affect a partial normalization of the biochemical changes associated with alloxan-induced diabetes mellitus in rats. Furthermore, the study indicated that treatment of cloves with 10 kGy of gamma irradiation had no significant effect on the antidiabetic properties of the extract made from such cloves. This confirms the suitability of irradiation for the improvement of the hygienic quality of cloves.

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Antioxidant role of Umbelliferone in STZ-diabetic rats

Cited by 105 publications

References 33 publications

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Untitled

Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

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Antioxidant role of Umbelliferone in STZ-diabetic rats

Cited by 105 publications

References 33 publications

Exogenous Hydrogen Sulfide (H2S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Exogenous Hydrogen Sulfide (H2S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Untitled

Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

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Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats