Antioxidant Role of Sodium Selenite on Ammonium Sulphate Induced Oxidative Stress in Rats

Abstract

Ammonia is an important source of nitrogen metabolism and it is necessary for synthesis of protein and amino acids. An excessive level of ammonia leads to disturbance in the physiological functions of the body. High concentrations of ammonia enter into the body, because of environmental pollution, urea cycle disorders, liver failure and ingestion of ammonium salts cause physiological disturbance and damage of organs. The present study is to investigate the possibilities of the protective role of Selenium in Ammonium Sulphate (AS)-induced stress in the rat brain and liver. Rats were divided into four groups (six animals in each group). Group I (GI) is served as control, Group II (AS) rats received 18.3 mg/kg b.w of ammonium sulphate via intraperitonially (i.p) injection, Group III (Ss) rats administered with Sodium selenite (0.3 mg/kg b.wi.p) and Group IV (AS + Ss) treated with both of AS (18.3 mg/kg bwi.p) plus Ss (0.3 mg/kg b.wi.p). Acute intoxication of AS treated rats has shown that significantly decreased levels of antioxidant enzymes; namely Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), and increased levels of Xanthine oxidase (XOD) levels in brain and liver tissues. Treatments with Ss reversed the ASinduced alteration of antioxidant defence enzyme levels.Selenium administration might be scavenging the excess of ammonium ions and significantly prevent the oxidative stress in liver and brain.

Disturbances in Thyroid Hormone Metabolism in Rats Exposed to γ- Radiation and Carbon Tetrachloride: The Role of N- acetyl cysteine and Sodium Selenite

“…NAC, which is a precursor of cysteine and glutathione, can suppress ROS production (Mercantepe et al, 2019). Also, sodium selenite, which can regulate the cellular antioxidant capacity (Amuru et al, 2019), has an important role in the metabolism of thyroid NAHED ABDEL-AZIZ hormones, where it is considered as an integral part of deiodinase enzymes responsible for activation and inactivation of thyroid hormones (Sobolev et al, 2018).…”

“…Moreover, it was found that oral administration of NAC is more efficient than that of GSH due to its better absorption where it is rapidly and almost completely absorbed after oral administration; only 3% is excreted in the feces (Borgstrom et al, 1986). In addition, sodium selenite -the most commonly used form of Se supplements -possesses an antioxidant activity and it may have a therapeutic role in free radicals-mediated diseases (Merkord et al, 2017) and against the toxicity of different chemical and physical agents (Hanafi, 2007;Ahmadvand et al, 2014;Abdel Samie et al, 2017;Amuru et al, 2019). Since, Se is considered an essential part of different antioxidant enzymes, such as GPx and thioredoxin , it plays an important role in the antioxidant defense mechanisms in the body.…”

“…Selenium is an essential element involved in the regulation of cellular antioxidant capacity (Amuru et al, 2019) and thyroid hormone metabolism (Sobolev et al, 2018). Moreover, it was reported that selenium supplementation prevented Cdinduced hepatotoxicity through alleviation of endoplasmic reticulum stress and modulation of endoplasmic reticulum -resident selenoproteins (Zhang et al, 2020).…”