Antioxidant-Rich Diet, GSTP1 rs1871042 Polymorphism, and Gastric Cancer Risk in a Hospital-Based Case-Control Study

Abstract

BackgroundChronic gastritis along with Helicobacter pylori (H. pylori) infection has been implicated in inflammatory response-related genes linked to the causation of gastric cancer. Glutathione S-transferase Pi (GSTP1) plays a role in regulating oxidative stress and detoxification against carcinogenesis. In this study, we aimed to determine whether an antioxidant-rich diet is associated with gastric cancer risk and identify how this association could be altered by GSTP1 genetic variants.MethodsThis study included 1,245 participants (415 cases and 830 controls) matched for age and sex. The dietary antioxidant capacity was estimated based on the oxygen radical absorbance capacity (ORAC) incorporated with a semiquantitative food frequency questionnaire. Five single nucleotide polymorphisms (SNPs) of GSTP1 (rs1695, rs749174, rs1871042, rs4891, and rs947895) were selected among the exome array genotype data.ResultsHigh dietary ORAC was inversely associated with gastric cancer (hydrophilic ORAC OR T3vs. T1, 95% CI = 0.57, 0.39–0.82, P = 0.004; lipophilic ORAC = 0.66, 0.45–0.95, P = 0.021; total phenolics = 0.57, 0.39–0.83, P = 0.005). The polymorphism rs1871042 increased the risk of gastric cancer (OR, 95% CI = 1.55, 1.10–2.16, P = 0.01, CT+TT vs. CC). A remarkably reduced risk of gastric cancer was observed among those who had a high dietary ORAC according to rs1871042 polymorphism (hydrophilic ORAC OR T3vs. T1, 95% CI = 0.36, 0.17–0.78, P for trend = 0.013; lipophilic ORAC = 0.58, 0.37–0.93, P for trend = 0.021; total phenolics = 0.38, 0.17–0.83, P for trend = 0.019).ConclusionsOur findings indicate that dietary ORAC intake may be inversely associated with the risk of gastric cancer altered by genetic variants of GSTP1, providing new intervention strategies for gastric cancer patients.

Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study

“…Several dietary factors (i.e., an antioxidant based diet or soy products including isoflavones) have been reported to interact with genetic factors affecting GC risk [ 13 , 14 , 27 ]. Kim et al (2020) reported that the polymorphism of glutathione S-transferase Pi ( GSTP1 ) rs1871042 increases the risk of GC (OR= 1.55, 95% CI = 1.10–2.16) [ 13 ]. However, they found that an antioxidant-rich diet might reduce the risk of GC according to the rs1871042 polymorphism.…”

“…Indeed, Yang et al (2012) reported that participants with a risk allele in the MAP3K1 gene (rs16886448 and rs252902) showed significantly higher GC risk [ 5 ]. Fortunately, several dietary factors (i.e., an antioxidant based diet or soy products including isoflavones) have been reported to interact with genetic factors that affect GC risk [ 13 , 14 ]. In particular, soy products are abundant in phytoestrogens such as genistein, daidzein, and glycitein [ 15 ], which can mimic the function of estrogen.…”

Dietary Polyphenol Intake and Gastric Cancer: A Systematic Review and Meta-Analysis

“…Diamonds show the pooled effect. Abbreviations: RR, relative risk; Ca, number of cases; Co, number of controls; n, number of events; N, number of patients [ 4 , 5 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Gastric cancer risk is reduced by a predominance of antioxidant factors in the oxidative balance: a hospital-based case-control study in Korea

“…and lifestyle (e.g., smoking and alcohol consumption) factors through a multistage process of gastric carcinogenesis [42][43][44]. Our previous study has examined the association between the incidence of GC and the dietary antioxidant capacity based on the oxygen radical absorbance capacity [45]. Several studies have indicated…”