Antioxidant response to artichoke leaf extract supplementation in metabolic syndrome: A double-blind placebo-controlled randomized clinical trial

Rezazadeh, Khatereh; Aliashrafi, Soodabeh; Asghari‐Jafarabadi, Mohammad; Ebrahimi-Mameghani, Mehrangiz

doi:10.1016/j.clnu.2017.03.017

Cited by 23 publications

(30 citation statements)

References 29 publications

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“…However, the effects of the common FTO variant rs9939609 on metabolic parameters might be explained by the possible relationship of FTO with many metabolic pathways, which are largely unknown. Furthermore, as reported in our previous study (Rezazadeh et al, ), the evidence showed that ALE supplementation could decrease TG level (Qiang et al, ; Shimoda et al, ). Antihypertriglyceridemic effect of ALE might be mediated by active components of ALE (sesquiterpenes and sesquiterpene glycosides) and inhibition of gastric emptying (Shimoda et al, ).…”

Section: Discussionsupporting

confidence: 75%

Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2‐rs7903146 and FTO‐rs9939609 polymorphisms

Rezazadeh

Rahmati-Yamchi

Mohammadnejad

et al. 2017

Phytotherapy Research

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The metabolic syndrome (MetS) is a multicomponent condition with a complex etiology involving genetic and environmental factors. Artichoke leaf extract (ALE) has shown favorable effects on lipid and glucose metabolism. The present study aimed to investigate the effects of ALE supplementation on metabolic parameters in women with MetS, using a nutrigenetics approach. In this double-blind randomized clinical trial, 50 women (aged 20-50 years) with MetS were randomly allocated into the two groups: "ALE group" (received 1,800 mg hydroalcoholic extract of artichoke as four tablets per day) and "placebo group" (received placebo consisted of corn starch, lactose, and avicel as four tablets per day) for 12 weeks. The biochemical and anthropometric parameters were determined before and after the intervention. The FTO-rs9939609 and the TCF7L2-rs7903146 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism. In carriers of A allele of the FTO-rs9939609, ALE supplementation resulted in a statistically significant decrease in serum triglyceride level compared with placebo (−19.11% vs. 10.83%; p < .05), with no other significant differences between the two groups. The TCF7L2-rs7903146 polymorphism showed no interaction with response to ALE (p > .05). These findings suggest that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO-rs9939609 polymorphism in women with MetS.

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Section: Discussionsupporting

confidence: 75%

Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2‐rs7903146 and FTO‐rs9939609 polymorphisms

Rezazadeh

Rahmati-Yamchi

Mohammadnejad

et al. 2017

Phytotherapy Research

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“…Our recent double‐blind, randomized controlled trial on 80 patients with metabolic syndrome indicated that supplementation with hydroalchoholic extract of artichoke leaf (1800 mg/day) decreased significantly oxidized‐LDL (ox‐LDL) level compared with placebo after 12 weeks. But, there were no significant differences in MDA, SOD, GPx, and total antioxidant capacity levels between and within groups (Rezazadeh, Aliashrafi, et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…However, there are very limited clinical trials considering antioxidant properties of artichoke (Rezazadeh, Aliashrafi, Asghari‐Jafarabadi, & Ebrahimi‐Mameghani, ; Skarpanska‐Stejnborn, Pilaczynska‐Szczesniak, Basta, Deskur‐Smielcka, & Horoszkiewicz‐Hassan, ). It is hypothesized that the head and leaves of artichoke and their extract could protect the body against oxidative stress induced by various active oxidant or toxins.…”

Section: Introductionmentioning

confidence: 99%

The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta‐analysis of animal studies

Salekzamani

Ebrahimi-Mameghani

Rezazadeh

2018

Phytotherapy Research

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Current evidence has shown antioxidant activity of artichoke as a potent source of antioxidant compounds. However, it seems that the antioxidant activity of artichokehas not yet been reviewed. Therefore, the present study was designed to perform a systematic review of human studies, animal models, and in vitro systems and to conduct a meta-analysis of animal studies on the antioxidant effects of artichoke. We searched four electronic databases till April 2018 using relevant keywords. All English language articles were assessed. For animal studies, standardized mean difference was pooled using a random effects model. The included studies were evaluated for eligibility and risk of bias. Thirty-nine articles (two human, 23 animal, and 14 in vitro studies) were reviewed. The results of in vitro systems supported the antioxidant effect of artichoke, whereas limited clinical trials indicated no change or a slight improvement of antioxidant status. Finding of animal studies indicated that artichoke extract supplementation increased superoxide dismutase, catalase, glutathione, and glutathione peroxidase level in liver, as well as, decreased malondialdehyde level in liver and plasma of animals with induced disease significantly compared with comparison group. This meta-analysis provided convincing evidence for antioxidant activity of artichoke in animals.

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“…Evidence currently available shows that artichoke administration can improve lipid profile in patients with hypercholesterolemia, metabolic syndrome, overweight, type 2 diabetes mellitus, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis [ [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]]. The main effects of artichoke administration on lipid profile are related to the observed reductions in LDL, TC and TG serum levels.…”

Section: Lipid Profilementioning

confidence: 99%

“…The dosage of ALE deemed to be effective ranges from 2 to 3 g/d [21,26,27], and the amount of chlorogenic acid found at those levels is higher when compared to its amount in green coffee extract [36,37]. Green (or raw) coffee is an important source of chlorogenic acids, reaching levels of up to 14% in dry matter [36,37].…”

Section: Artichoke Its Polyphenols and Phytosterols: Mechanisms Of Amentioning

confidence: 99%

The effect of artichoke on lipid profile: A review of possible mechanisms of action

Santos

Bueno

Mota

2018

Pharmacological Research

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Cardiovascular disease is a highly prevalent issue worldwide, and one of its main manifestations, dyslipidaemia, needs more attention. Cooked artichoke (Cynara scolymus) hearts or artichoke leaf extract (ALE) are believed to be helpful in the treatment of dyslipidaemia. In this narrative review, we provide a brief overview of the potential impact of artichoke consumption on lipid profile. We appraised the Cochrane, MEDLINE and Web of Science databases, and included articles published between 2000 and June 2018 on intervention in humans only. The main potential of ALE administration observed on lipid profile relates to decreased serum LDL, total cholesterol and triglyceride concentrations, although no strong evidence for increasing HDL appears to exist. Evidence suggests that decreases of 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides, can be attributed to 2 to 3 g/d of ALE, in which its components luteolin and chlorogenic acid may play a key role. On the other hand, the effects of cooked artichoke hearts can be attributed mainly to its soluble fibres, particularly inulin. Despite the convincing evidence on its health benefits, additional long-term clinical trials are pivotal to fully elucidate the potential effects of ALE administration on positive cardiovascular outcomes.

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Antioxidant response to artichoke leaf extract supplementation in metabolic syndrome: A double-blind placebo-controlled randomized clinical trial

Cited by 23 publications

References 29 publications

Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2‐rs7903146 and FTO‐rs9939609 polymorphisms

Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2‐rs7903146 and FTO‐rs9939609 polymorphisms

The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta‐analysis of animal studies

The effect of artichoke on lipid profile: A review of possible mechanisms of action

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