Antioxidant property of quercetin–Cr(III) complex: The role of Cr(III) ion

Chen, Weijun; Sun, Shaofang; Cao, Wei; Yan, Liang; Song, Jirong

doi:10.1016/j.molstruc.2008.08.008

Cited by 115 publications

(64 citation statements)

References 31 publications

(28 reference statements)

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“…Fe(II), 20 Fe(III), 12 Sn(II) 14 and Cr(III) 21 has already been reported. In a previous report, copper-quercetin complex was synthesized and conrmed to be much more effective in free radical scavenging activity than the free quercetin.…”

mentioning

confidence: 91%

“…Despite increasing studies of various metal-avonoids complex and their biological activities, 11,15,17,18,21,22 research about the complexation between luteolin and manganese(II) cation has been limited. Therefore, the purpose of the present study was to examine the complex formation between luteolin and manganese(II) cation and conrm the complexation sites in luteolin by means of UV-visible spectroscopy, infrared spectroscopy, thermogravimetric analysis and elemental analysis.…”

mentioning

confidence: 99%

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Enhanced antioxidant activity, antibacterial activity and hypoglycemic effect of luteolin by complexation with manganese(ii) and its inhibition kinetics on xanthine oxidase

Dong

Yang

et al. 2017

RSC Adv.

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The present study aims to improve the biological activities of luteolin by complexation with manganese(II).UV-visible spectroscopy, infrared spectroscopy, thermogravimetric analysis and elemental analysis were adopted to assess the relevant interaction of luteolin and manganese(II) ions and the chelation sites. The antioxidant activity, hypoglycemic effect and antimicrobial activity of luteolin-manganese(II) complex with respect to its parent luteolin and the inhibition effect of which on xanthine oxidase were investigated and compared. The spectroscopic data indicated that luteolin reacts with manganese(II) cations through the chelation sites of 5-hydroxy and 4-carbonyl in two luteolin molecules. Antioxidant and antibacterial activity were enhanced after the complexation of manganese(II) cations with luteolin. An inhibition effect assay found that luteolin and luteolin-manganese(II) complex reversibly inhibited xanthine oxidase in a competitive manner. Luteolin-manganese(II) complex had a more remarkable hypoglycemic effect than luteolin by increasing the glucose consumption in liver tissue.

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mentioning

confidence: 91%

mentioning

confidence: 99%

Enhanced antioxidant activity, antibacterial activity and hypoglycemic effect of luteolin by complexation with manganese(ii) and its inhibition kinetics on xanthine oxidase

Dong

Yang

et al. 2017

RSC Adv.

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“…The studies relying on the synthesis of new derivatives of biologically important phenolic compounds are very important, because as a result the new compounds with the enhanced desirable biological properties, i.e., antimicrobial, antioxidant and anticancer [27,28], might be obtained. Many studies revealed that complexation with copper (II) or chromium (III) improves antioxidant properties of metal complexes comparing with the free ligand [19,29] or complexation with rare earth metals (III) increases the antitumor activity of ligand [30].…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic, thermogravimetric and biological studies of Na(I), Ni(II) and Zn(II) complexes of quercetin

Kalinowska

Świderski

Matejczyk

et al. 2016

J Therm Anal Calorim

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The Na(I), Zn(II) and Ni(II) complexes with quercetin have been synthesized. The composition of these compounds was established by means of elemental and thermogravimetric analyses. To study the molecular structure of synthesized compounds, many miscellaneous analytical methods, which complement one another, were used: infrared (FT-IR), Raman (FT-Raman) and electronic absorption UV/VIS spectroscopy. For studying the cytotoxic and genotoxic activity of synthesized compounds, bioreporter strain of Escherichia coli K-12 recA::gfpmut2 has been used.

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“…Among the flavonoids, quercetin is known as a powerful antioxidant and free radical-scavenging substance (8) . Furthermore, quercetin also posseses antiapoptotic effects (9) .…”

Section: Resultados: a Administração De Quercetina Diminuiu O Afinamementioning

confidence: 99%

Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model

Arıkan¹,

Erşan²,

Karaca³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Purpose: This study aimed to investigate the effect of quercetin on apoptotic cell death induced by ischemia-reperfusion (I/R) injury in the rat retina. Methods: Twenty-four rats were divided into four equal groups: control, ischemic, solvent, and quercetin. I/R injury was achieved by elevating the intraocular pressure above the perfusion pressure. Intraperitoneal injections of 20 mg/kg of quercetin and dimethyl sulfoxide (DMSO) were performed in the quercetin and solvent groups, respectively, immediately prior to I/R injury, and the researchers allowed for the retinas to be reperfused. Forty-eight hours after injury, the thicknesses of the retinal ganglion cell layer (RGCL), inner nuclear layer (INL), inner plexiform layer (IPL), outer plexiform layer (OPL), and outer nuclear layer (ONL) were measured in all groups. Moreover, the numbers of terminal deoxynucleotidyl transferase dUTP nick-end-labeled [TUNEL (+)] cells and caspase-3 (+) cells in both INL and ONL were evaluated in all groups. Results: The administration of quercetin was found to reduce the thinning of all retinal layers. The mean thickness of INL in the quercetin and ischemic groups was 21 ± 5.6 µm and 16 ± 6.4 µm, respectively (P<0.05). Similarly, the mean thickness of ONL in the quercetin and ischemic groups was 50 ± 12.8 µm and 40 ± 8.7 µm, respectively (P<0.05). The antiapoptotic effect of quercetin in terms of reducing the numbers of both TUNEL (+) cells and caspase-3 (+) cells was significant in INL. The mean number of TUNEL (+) cells in INL in the ischemic and quercetin groups was 476.8 ± 45.6/mm 2 and 238.72 ± 251/mm², respectively (P<0.005). The mean number of caspase-3 (+) cells in INL of ischemic and quercetin groups was 633.6 ± 38.7/mm 2 and 342.4 ± 36.1/mm 2 , respectively (P<0.001). Conclusion:The use of quercetin may be beneficial in the treatment of retinal I/R injury because of its antiapoptotic effect on the retinal layers, particularly in INL.

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Antioxidant property of quercetin–Cr(III) complex: The role of Cr(III) ion

Cited by 115 publications

References 31 publications

Enhanced antioxidant activity, antibacterial activity and hypoglycemic effect of luteolin by complexation with manganese(ii) and its inhibition kinetics on xanthine oxidase

Enhanced antioxidant activity, antibacterial activity and hypoglycemic effect of luteolin by complexation with manganese(ii) and its inhibition kinetics on xanthine oxidase

Spectroscopic, thermogravimetric and biological studies of Na(I), Ni(II) and Zn(II) complexes of quercetin

Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model

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