Antioxidant properties of violacein: Possible relation on its biological function

Konzen, Marlon; Marco, Daniela De; Cordova, Clarissa A.S.; Vieira, Tiago O.; Antônio, Regina Vasconcellos; Creczynski-Pasa, Tânia B.

doi:10.1016/j.bmc.2006.09.013

Cited by 106 publications

(75 citation statements)

References 41 publications

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“…Interestingly, violacein has been described to induce apoptosis in mammalian cell lines (Ferreira et al 2004), which suggests a related mechanism underlying the violacein-induced decease of rotifers and daphnids. There is increasing evidence for the involvement of the antioxidant activity of violacein in the induction process (Konzen et al 2006;C. Matz unpubl.).…”

Section: Discussionmentioning

confidence: 99%

Toxicity of violacein‐producing bacteria fed to bacterivorous freshwater plankton

Deines

Matz

Jürgens

2009

Limnology & Oceanography

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Chemical defenses have been hypothesized to be widespread among aquatic bacteria, but few studies have assessed the susceptibility of pelagic consumers to bacterial secondary metabolites. In this study, we determined the effect of bacteria containing the indole alkaloid violacein on a range of freshwater plankton organisms that ingest bacteria. Growth and survival of two nanoflagellates (Bodo saltans, Ochromonas sp.), two ciliates (Colpidium campylum, Tetrahymena pyriformis), two rotifers (Keratella cochlearis, Brachionus calcyfloris), and adults and juveniles of the cladoceran Daphnia magna were examined in laboratory experiments in which these organisms were fed bacterial diets supplemented with violacein-producing bacteria such as Janthinobacterium lividum and Chromobacterium violaceum. Unselective uptake of violacein-producing bacteria resulted in significantly lower survivorships, indicating acute toxicity to all zooplankton taxa tested. The presence of 10% C. violaceum in an otherwise nontoxic bacterial diet, equivalent to 9 ng violacein mL 21 , reduced growth rates and peak abundances of flagellates, ciliates, and rotifers by 18-100%. For D. magna, wild-type C. violaceum was poisonous starting at concentrations ,1 3 10 6 cells mL 21 , whereas a violacein-deficient mutant did not have any lethal effect on the animals. Species-specific variability in predator susceptibility was explained by the negative correlation between toxin sensitivity and biomass-specific clearance rates. The susceptibility of a broad spectrum of planktonic bacterial consumers to violacein-producing bacteria illustrates the potential effect of bacterial bioactives on the structure of aquatic food webs, biodiversity, and ecosystem functioning.

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Section: Discussionmentioning

confidence: 99%

Toxicity of violacein‐producing bacteria fed to bacterivorous freshwater plankton

Deines

Matz

Jürgens

2009

Limnology & Oceanography

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“…Extremely high level of resistance either to gamma radiation or UV radiation or both, was found for the members of the genus Deinococcus and Rubrobacter (5,7,20). The production of metabolites by bacteria is of great interest for pharmacological applications (12). Many of the bacterial metabolites may exhibit antibiotic and cytotoxic activities (12) and are excellent source of antioxidants (14).…”

Section: Introductionmentioning

confidence: 99%

“…The production of metabolites by bacteria is of great interest for pharmacological applications (12). Many of the bacterial metabolites may exhibit antibiotic and cytotoxic activities (12) and are excellent source of antioxidants (14). The aim of the present research was by EPR spectroscopy methods to investigate the radical scavenging abilities of SQGD, formerly isolated from the fermentation broth of a novel radio resistant bacterium Bacillus sp.…”

Section: Introductionmentioning

confidence: 99%

A New Antioxidant with Natural Origin Characterized by Electron Paramagnetic Resonance Spectroscopy Methods

Zheleva

Karamalakova

Nikolova

et al. 2012

Biotechnology & Biotechnological Equipment

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“…High amount of oxidative stress causing free radical also activate mitogen activated protein kinase pathways which too are involved in increasing inflammation and cellular damage [18]. It is mainly synthesized by Cromobacterium violaceum but is also found to be synthesized by Janthinobacterium lividum and Alteromonasluteo violacea under specific conditions [19,20]. It is a purple pigment which is insoluble in water but soluble in DMSO, methanol and ethyl acetate.…”

Section: Introductionmentioning

confidence: 99%

“…Structural inhibition of MMPs by rutin was reported by Selvaraj et al [36]. Violacein a microbial pigment is well accepted for its great antioxidant and anti-inflammatory potential [19,25]. Inhibition of MMPs is proposed by three mechanisms.…”

mentioning

confidence: 96%

An In-silico Approach to Explore the Possible Multifunctional Neuroprotective Efficacy of Violacein against Ischemic Stroke

Verma¹,

Ak²

2017

J In Silico In Vitro Pharmacol

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Introduction: Cerebral ischemia arise due to insufficient/ interrupted blood supply to brain and is accompanied by pathologies like degradation of extracellular matrix resulting in blood brain barrier disruption, intra cranial haemorrhage, activation of astroglial cells and hence death of neurons. In addition, oxidative stress and inflammation is common to all neurodegenerative diseases enhancing the harmful consequences of diseases. Matrix Metalloproteinases (MMP) are normally involved in extracellular matrix remodelling and are regulated while injury and inflammation in tissue. Over expression of MMP2 and MMP9 results in progression of ischemic conditions by extracellular matrix degradation thus compromising the structural integrity of Blood Brain Barrier (BBB) proving them a potent targets for the disease. Violacein (source: Chromobacterium violaceum), purple pigment from microbial origin is a bisindole have high anti-inflammatory, anti-oxidant, anti-bacterial, anticancer and anti-parasitic properties. Present study is to study the effective potential of violacein against cerebral ischemia.

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Antioxidant properties of violacein: Possible relation on its biological function

Cited by 106 publications

References 41 publications

Toxicity of violacein‐producing bacteria fed to bacterivorous freshwater plankton

Toxicity of violacein‐producing bacteria fed to bacterivorous freshwater plankton

A New Antioxidant with Natural Origin Characterized by Electron Paramagnetic Resonance Spectroscopy Methods

An In-silico Approach to Explore the Possible Multifunctional Neuroprotective Efficacy of Violacein against Ischemic Stroke

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