Antioxidant Properties of Some Medicinal Lamiaceae (Labiatae) Species

Ozgen, Ufuk; Mavi, Ahmet; Terzi, Zeynep; Yıldırım, Ali Osman; Coşkun, Maksut; Houghton, Peter J.

doi:10.1080/13880200600592061

Cited by 70 publications

(49 citation statements)

References 50 publications

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“…Teucrium chamedrys and T. montanum are very rich in phenolic compounds with very strong biological activity and antioxidative effects (Č anadanović- Brunet et al 2006;Ozgen et al 2006;Gursoy and Tepe 2009;Stanković et al 2010;Stanković et al 2011b). Stankovic et al (2011a) reported that extracts from different Teucrium species caused cytotoxicity and induced apoptosis in human HCT-116 cells (human colon cancer cell line), hence they could be considered suitable natural anticancer products.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of genotoxicity and antimutagenicity of methanolic extracts from Teucrium chamaedrys and Teucrium montanum in human lymphocytes using micronucleus assay

et al. 2013

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Since Teucrium chamaedrys and Teucrium montanum are the most popular plants used in the treatment of many diseases, we evaluated genotoxic potential of their methanolic extracts on cultured human peripheral blood lymphocytes (PBLs) using cytokinesis-block micronucleus (MN) assay. Cultures were treated with four concentrations of both plants (125, 250, 500 and 1,000 lg/ml), both separately and in combination with mitomycin C (MMC). The results revealed that extract of T. chamaedrys administered at the tested concentrations did not significantly affect the mean MN frequency in comparison to untreated cells. Methanolic extract of T. montanum increased the mean MN frequency in PBL at the tested concentrations, but significantly only at the concentration of 1,000 lg/ml. In all tested concentrations, the extract of T. chamaedrys significantly reduced the MMC-induced MN frequency, in a dose dependent manner (r = -0.687, p \ 0.01). The extract of T. montanum decreased the MMC-induced MN frequency at the tested concentrations, but statistically only at 125 lg/ ml. Both extracts administered alone did not significantly affect the nuclear division index (NDI) at the tested concentrations. In the combined treatments with MMC, the extract obtained from T. chamaedrys in the concentrations of 500 and 1,000 lg/ml significantly decreased NDI values in comparison to MMC-treated cells alone, while the extract of T. montanum significantly decreased NDI at all tested concentrations. Both extracts nonsignificantly decreased NDI at all tested concentrations in comparison to untreated cells. Our results suggest the important function of T. chamaedrys extract in cancer therapy, this methanolic extract may prevent genotoxic effects of chemotherapy in PBLs.

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Section: Discussionmentioning

confidence: 99%

Comparative study of genotoxicity and antimutagenicity of methanolic extracts from Teucrium chamaedrys and Teucrium montanum in human lymphocytes using micronucleus assay

et al. 2013

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“…Various Thymus species are aromatic plants of Mediterranean flora, commonly used as spices, food preservatives, and traditional medicine (Baytop, 1999;Ismaili et al, 2004;Sokmen et al, 2004). Consequently, there are numerous studies on the antioxidant potential of Thymus species growing in various regions of the world (Ismaili et al, 2004;Sokmen et al, 2004;Agbor et al, 2005;Ozgen et al, 2006;Vitalini et al, 2006). Recent reports show that various Thymus and several Ziziphora species have antioxidant potential (Ismaili et al, 2004;Sokmen et al, 2004;Agbor et al, 2005;Salehi et al, 2005;Ghafari et al, 2006;Ozgen et al, 2006;Vitalini et al, 2006).…”

Section: Antioxidant and Dpph Radical Scavenging Activities Of The Exmentioning

confidence: 99%

“…Medicinal plants and herbs are diverse sources of natural antioxidants. Therefore, there is a great interest concerning the antioxidant properties of medicinal plants and herbs (Velioglu et al, 1998;Cakir et al, 2003Cakir et al, , 2006Ismaili et al, 2004;Sokmen et al, 2004;Salehi et al, 2005;Erdemoglu et al, 2006;Ozgen et al, 2006). This study was undertaken to determine the potential antimicrobial, antioxidant, and free radical scavenging activities of the extracts of some Turkish native herbs.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antioxidant Activities of Some Plants Used as Remedies in Turkish Traditional Medicine

Unal

Mavi

Kara

et al. 2008

Pharmaceutical Biology

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The antimicrobial activities of chloroform, acetone, ethanol, and water extracts of 25 plants, mostly used as remedies against various diseases in Turkish traditional medicine, were tested against 10 pathogenic bacteria and one fungus (Candida albicans) using the disk diffusion method. Among the tested plant species, Ziziphora clinopodioides Lam (Labiatae), Thymus fallax Fisch et Mey. (Labiatae), and three Hypericum species [H. heterophyllum Vent., H. hyssopifolium Chaix. subsp. elongatum (Ledeb.) Woron var. elongatum, and H. scabrum L.] (Guttiferae) showed antimicrobial activity at a broader spectrum. In particular, chloroform, acetone, and ethanol extracts of Z. clinopodioides inhibited the growth of all microbial species. Minimal inhibition concentration values of Z. clinopodioides extracts were also found to be low. The antioxidant activity of the acetone, ethanol, and water extracts of 20 plants was also evaluated by lipid peroxidation inhibition and DPPH free radical scavenging methods. It was found that water, ethanol, and acetone extracts of Z. clinopodioides, T. fallax, three Hypericum species, Artemisia santonicum L. (Compositae), and Echinophora tenuifolia L. subsp. sibthorpiena (Umbelliferae) have strong antioxidant activities among the tested plant species. In general, there is a correlation between the antioxidant potential and total phenolic contents of the extracts. In light of the current study, it can be concluded that Z. clinopodioides and T. fallax may have potential use in the food industry as antioxidants and antimicrobial herbs, as well as pharmaceutical interest.

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“…The free radicals in human body develops a great number of pathological states like inflammation, atherosclerosis, stroke, heart disease, diabetes mellitus, multiple sclerosis, cancer, Parkinson's disease, Alzheimer's disease, etc. (Ozgen et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and Antioxidant Activities of Cucumis sativus Leaves

et al. 2015

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This study was carried out to evaluate the anti-inflammatory and antioxidant activities of Cucumis sativus Linn. (Family: Cucurbitaceae) leaves. The methanolic extract of C. sativus leaves (MCS) was investigated for antiinflammatory activities in Long Evans rat model at two different doses of 150 and 250 mg/kg body weight and the effects were compared with the standard, indomethacin (10 mg/kg body weight). It exhibited highest antiinflammatory activity at the dose 250 mg/kg. In the formalin test, the extract at both doses (150 and 250 mg/kg body weight) significantly prevented the increase in volume of paw edema (P<0.05 and P<0.001). In carrageenan-induced paw edema test the MCS significantly (P≤0.001) reduced inflammation by 57.35 % (150 mg/kg body weight) and 72.06% (250 mg/kg body weight) in comparison to the standard drug, indomethacin (79.41%) at the end of 5h. MCS was also screened for DPPH scavenging activity, total antioxidant capacity, reducing ability as well as total phenolics content to assess its antioxidant potential. Total phenolic content and total antioxidant capacity of MCS were found to be 262.31 mg/g equivalent of gallic acid and 267.2 mg/g equivalent of ascorbic acid, respectively. The IC 50 of free radical scavenging of DPPH was 13.06 μg/ml while that of standard ascorbic acid was 13.17 μg/ml. The reducing power of MCS was found to be concentration dependent.

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Antioxidant Properties of Some Medicinal Lamiaceae (Labiatae) Species

Cited by 70 publications

References 50 publications

Comparative study of genotoxicity and antimutagenicity of methanolic extracts from Teucrium chamaedrys and Teucrium montanum in human lymphocytes using micronucleus assay

Comparative study of genotoxicity and antimutagenicity of methanolic extracts from Teucrium chamaedrys and Teucrium montanum in human lymphocytes using micronucleus assay

Antimicrobial and Antioxidant Activities of Some Plants Used as Remedies in Turkish Traditional Medicine

Anti-inflammatory and Antioxidant Activities of Cucumis sativus Leaves

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