Antioxidant Properties of Plant-Derived Phenolic Compounds and Their Effect on Skin Fibroblast Cells

Abstract

Plants are rich sources of a diverse range of chemicals, many of which have significant metabolic activity. One large group of secondary compounds are the phenolics, which act as inter alia potent reactive oxygen scavengers in cells, including fibroblasts. These common dermis residue cells play a crucial role in the production of extracellular matrix components, such as collagen, and maintaining the integrity of connective tissue. Chronic wounds or skin exposure to UV-irradiation disrupt fibroblast function by the generation of reactive oxygen species, which may damage cell components and modify various signaling pathways. The resulting imbalance may be reversed by the antioxidant activity of plant-derived phenolic compounds. This paper reviews the current state of knowledge on the impact of phenolics on fibroblast functionality under oxidative stress conditions. It examines a range of compounds in extracts from various species, as well as single specific plant-derived compounds. Phenolics are a good candidate for eliminating the causes of skin damage including wounds and aging and acting as skin care agents.

Topical Artocarpus communis Nanoparticles Improved the Water Solubility and Skin Permeation of Raw A. communis Extract, Improving Its Photoprotective Effect

“…Natural antioxidants, such as plant extracts [ 17 ], vitamins [ 18 ], and carotenoids [ 19 ], can be active ingredients in skin care products for attenuating oxidative stress and photodamage [ 20 ]. A. communis methanol extract has been revealed to have great anti-inflammatory and antioxidant activities for preventing UV-induced skin damage [ 2 , 21 ].…”

The Feasibility of Utilizing Cultured Cordyceps militaris Residues in Cosmetics: Biological Activity Assessment of Their Crude Extracts

“…Phenolics are secondary metabolites that have been broadly studied, characterized, and isolated from several plants; they include phenolic acids, flavonoids, tannins, stilbenes, and lignans [32]. In cosmetics, phenolic compounds are commonly used as active ingredients, with the claim of multifunctional properties such as antioxidant, anti-aging, anti-wrinkle, anti-tyrosinase, anti-pollution, anti-glycation, anti-hyaluronidase, anti-collagenase, anti-elastase, anti-inflammatory, photoprotection, and microbial preservation activities [32][33][34][35]. To date, mushrooms and other microorganisms have been studied as alternative sources of potential phenolic compounds.…”

“…Nevertheless, natural antioxidants tend to be preferred due to the side effects of synthetic antioxidants, along with the arrival of natural trends in cosmetics. Natural antioxidants comprise a group of phenolic compounds, polysaccharides, proteins, peptides, vitamins, carotenoids, and minerals that are be available in natural resources; among them, plant polyphenols and phenolic acids have been the most studied and focused on for cosmetic applications [32,33,51]. At present, new alternative sources-especially fungi-are gaining interest in the study and investigation of their constituents for further development as natural antioxidants.…”

Determination of Phenolic Content, Antioxidant Activity, and Tyrosinase Inhibitory Effects of Functional Cosmetic Creams Available on the Thailand Market

“…The phenolic compounds in plant extracts promoted the skin whitening effects mechanistically via the removal of free radicals and the chelation of metal ions [ 89 , 90 ]. The strong antioxidant properties of the phenolic compounds can delay the aging process of the skin by counteracting the photo-aging process through the prevention of UV penetration, a reduction in inflammatory responses and oxidative stress, and by influencing specific survival signaling pathways (MAPK and PI3K/Akt pathways) [ 29 , 35 , 91 , 92 ]. Moreover, phenolic compounds exhibit depigmenting properties, by controlling the activity of tyrosinase, which is the key enzyme involved in the skin melanogenesis [ 3 , 16 ].…”