Antioxidant properties of Pelargonium graveolens L’Her essential oil on the reproductive damage induced by deltamethrin in mice as compared to alpha-tocopherol

Abstract

BackgroundExposure to the pyrethroid pesticide deltamethrin has been demonstrated to exert a wide range of effects on non-targeted organisms. The beneficial effects of geranuim essential oil (EO) as an antioxidant has been assessed in deltamethrin (DL) orally administered mice by studying whether the reprotoxicity caused by deltamethrin can be effectively combated with the geranium oil and the effects were compared to vitamin E, as the standard reference drug.ResultSixty male albino mice were divided into six equal groups: a control group, a group of mice was given deltamethrin (5 mg/kg b.w.), two groups were administered deltamethrin after having given geranium essential oil (67 mg/kg b.w.) or vitamin E (Vit E) (100 mg/kg b.w.), and two groups received only EO of geranium or Vit E. When compared to control, a dose of deltamethrin 5 mg/kg/day causes a decrease in the epididymal sperm count motility and viability and an increase in the number of abnormal morphology in spermatozoa. DL-exposed mice showed a significant increase of lipid peroxidation (LPP) in the testis compared to control animals.ConclusionEssential oil of geranium prevented testicular oxidative damage explored by reduced LPP and improved total sperm motility, viability and morphology in mice spermatozoa. Our study showed a positive influence of geranium essential oil in the animal male reproductive system similar than that of Vit E.

Protective Effects of Zinc as Antioxidant Against the Genotoxic Potential of Deltamethrin

“…This finding came in accordance with previous studies which reported that DM significantly decreased the antioxidant defense [9,15,28,29]. Also DM intoxication caused significant increase in NO concentration [ Table-2].…”

“…Genotoxicity of a compound usually expressed as its ability to induce DNA damage, which is often essential for mutagenesis and cancer transformation [49]. In the present study DM appears to induce mutation in TP53 and H-RAS genes [ Fig-1], [Fig-2], [ [29,[50][51][52]. It increased the expression of p53 and decreased expression of Bcl-2 genes in brain [53].…”

Pelargonium graveolens (Rose Geranium) - A Novel Therapeutic Agent for Antibacterial, Antioxidant, Antifungal and Diabetics

“…Slima et al found that P. graveolens essential oil produced a strong protective effect against oxidative stress damage and that a dose of 67 mg/kg/day was sufficient to reduce protein oxidation in the testes as well as reduce oxidative stress and lipid peroxidation. The oil also improved the poor quality of the sperm [25].…”

“…These effects when considered together lead to the conclusion that the Deltamethrin induced oxidative stress in the mice testes. When treated with the P. graveolens, the negative effects were reversed [25]. Slima et al found that P. graveolens essential oil produced a strong protective effect against oxidative stress damage and that a dose of 67 mg/kg/day was sufficient to reduce protein oxidation in the testes as well as reduce oxidative stress and lipid peroxidation.…”

“…Deltamethrin (DL) is one such toxin. In attempt to revert and prevent the negative effects of this toxin and others like it, attention was drawn back to traditional medicine [25]. An answer arose in Pelargonium graveolens, which is known for its antioxidant effects.…”