Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

Choi, Dong‐Young; Lee, Young-Jung; Hong, Jin Tae; Lee, Hwa-Jeong

doi:10.1016/j.brainresbull.2011.11.014

Cited by 263 publications

(149 citation statements)

References 131 publications

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“…In living organisms, a great number of biomolecules essential to life such as DNA, RNA, lipids, and proteins, can be oxidized by the generated ROS producing oxidative stress [6][7][8]14]. Among other substrates, NSAIDs are compounds that can be oxidized in the presence of Rfgenerated ROS and as shown can act as quenchers of electronically excited states of Rf (Eqs.…”

Section: Oxidation Processesmentioning

confidence: 99%

“…Oxidative stress is a process that occurs in early stages of ND and is considered an identifier mark for their detection as could be evaluated by DNA, RNA, lipids, and protein oxidation levels [6][7][8]. Simultaneously, several studies have observed an inverse correspondence between prolonged NSAID administration and the development of some ND in humans, (for review, see Ref.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) with Reactive Oxygen Species (ROS): Possible Biomedical Implications

Garcı́a¹,

Bregliani²,

Pajares³

2017

Pain Relief - From Analgesics to Alternative Therapies

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The present chapter deals on the interaction of nonsteroidal anti-inflammatory drugs (NSAIDs), diflunisal, indomethacin, meloxicam, tenoxicam and piroxicam with reactive oxygen species (ROS) photogenerated in aqueous solution by the vitamin riboflavin employed as a dye sensitizer. Simple techniques as substrate and oxygen consumption and more sophisticated time-resolved spectroscopic methods were employed for the kinetic and mechanistic evaluation of the deactivation of the in situ generated ROS singlet molecular oxygen (O 2 ð 1 Δ g Þ), superoxide radical anion (O •−2 ) and hydrogen peroxide (H 2 O 2 Þ by the mentioned NSAIDs. Results could be prudently extrapolated to a possible action of NSAIDs in the retardation or inhibition of neuroinflammatory disorders, in which oxidative agents such as ROS were found to be upregulated. Despite the potential benefit, some adverse effects in humans reported in relation with high doses of NSAIDs alert about the cares that have to be taken about their use.

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Section: Oxidation Processesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interaction of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) with Reactive Oxygen Species (ROS): Possible Biomedical Implications

Garcı́a¹,

Bregliani²,

Pajares³

2017

Pain Relief - From Analgesics to Alternative Therapies

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“…Natural polyphenolic compounds exhibit their antioxidant effect by quenching free radical species and/or promoting endogenous antioxidant capacity. Thus, the antioxidant properties certainly contribute to their neuroprotective effects [43] . Ellagic acid (EA), is a powerful non-flavonoid polyphenol compound with various pharmacological actions and said to be a degraded product of certain plant tannins [44] (Table 1).…”

Section: Polyphenol Ellagic Acid-targeting To Brain: a Hidden Treasurementioning

confidence: 99%

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Mehan¹,

Kaur²,

Parveen³

et al. 2015

International Journal of Neurology Research

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Alzheimer's disease is a severe neurodegenerative disorder that gradually results in loss of memory and impairment of cognitive functions in the elderly.Thedeposition of amyloid plaques is the primary event that leads to an oxidative and inflammatory reactions, neurofibrillary tangle formation, and ultimately neuronal death. The most prominent losses occur with cholinergic neurons that plays an important role in the formation of memory and cognitive functions. Insulin receptor numbers also altered, thusglucosemetabolism is defected in AD. Polyphenol ellagic acid (EA) possesses antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and cardioprotection activities.Activities of EA that are linked with protection of neuronal abnormalities like anti-depressant, antianxiety, anti-nociception. Ellagic acid inhibits β-secretase enzymatic activities, thus prevents the main pathologic hallmark of AD. There are varieties of herbal extracts and phytochemicals formulations extensively used to provide symptomatic relief to AD patients. Together these results our hypothesis that EA may prevent the neuronal dysfunctions as well as further work is also required to examine the pharmacological properties of EA in the protection of specially neurodegenerative disorder like AD. Here, we discuss how we can use the knowledge to improve treatment strategies of EA in AD and to explore the various signaling pathways involved in the progression of neuronal death.

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“…Biophenols are reported to affect various body systems, modulate immunity and fight pathogens and neoplasms [13]. Further, biophenols are proclaimed to affect mood, behaviour, memory and cognition [31][32][33][34][35]. Biophenols demonstrated-at least in vitro-abilities to modulate cell signalling pathways, react with specific receptors, interfere with cell division, modulate enzyme activities, regulate gene expression and affect epigenetics [13].…”

Section: What Is the Consensus?mentioning

confidence: 99%

Biography of biophenols: past, present and future

Obied

2013

FFHD

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ABSTRACT:Background: The term "biophenols" was first coined by Romeo and Uccella in 1996 to denote bioactive phenols in olives replacing the more common and less chemically accurate term "polyphenols". "Biophenols" has started gaining popularity beyond olive chemistry and currently used by researchers to refer to plant phenols in general. Biophenols constitute the largest group of secondary plant metabolites with ubiquitous presence in plants and wide spectrum of biological activities. During the last three decades, biophenols have seized scientific attention, lured industry and attracted consumers' interest due to their antioxidative potential in preservation of food and maintaining human health. For the first time, a definition for "biophenols" has been proposed to present a more precise and comprehensive umbrella term to encompass all phenolic compounds of botanical origin. In this article, the author is tracing the landmarks of the history of biophenol research; profiling contemporary research directions; highlighting research controversies and uncertainties; and presenting an outlook of the biophenols future research.

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Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

Cited by 263 publications

References 131 publications

Interaction of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) with Reactive Oxygen Species (ROS): Possible Biomedical Implications

Interaction of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) with Reactive Oxygen Species (ROS): Possible Biomedical Implications

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Biography of biophenols: past, present and future

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