Antioxidant properties of methanolic extract from Inula graveolens L.

Al–Fartosy, Adnan J. M.

doi:10.3906/tar-1010-1268

Cited by 10 publications

(20 citation statements)

References 16 publications

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“…The antioxidant activity of the azetidin-2-one (Z 2 a-Z 2 e, Z 2 g), 4-thiazolidinone (Z 2 B, Z 2 E) and 4selenazolidinone (Z 2 B', Z 2 E') were determined according to the β-carotene bleaching method [27]. The β-carotene bleaching method is based on the loss of the yellow color of β-carotene because of its reaction with radicals formed by linoleic acid oxidation in an emulsion and according to previous methods [28].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…The emulsion (3.8 mL) was added to tubes containing 0.2 mL of the prepared compounds and the reference (BHT) compound which was prepared by dissolving 0.01 g of these compounds in 0.2 mL of DMSO. The absorbance was read at 470 nm, and the samples were then subjected to thermal autoxidation at 45°C in a water bath for 2 h. Absorbance was measured every 15 min [27]. Antioxidant activity (AA) was calculated as the percent of inhibition relative to the control using the equation…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Reactive oxygen species (ROS) such as superoxide anions, hydrogen peroxide, hydroxyl, and nitric oxide radicals are generated during the bioorganic redox process and normal cellular metabolism. They play a significant role in oxidative stress related to the development and pathogenesis of life-limiting various diseases such as cancer, diabetes mellitus, arteriosclerosis, rheumatoid arthritis, and others [27].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Therefore, we expect that Z 2 d and other new synthetic compounds enter different metabolic pathways in the body that may modify differently from their structure and/or toxicity, and this requires further research. Again, the exact possible mechanism via which compound Z 2 b and the new other synthetic compounds protect against oxidative damage will be a matter of future studies and must be confirmed in a more controlled experimental design [27].…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Synthesis, Antimicrobial, Antioxidant, Toxicity and Anticancer Activity of a New Azetidinone, Thiazolidinone and Selenazolidinone Derivatives Based on Sulfonamide

2022

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A new series of azetidinone (Z2a-Z2e, Z2g), thiazolidinone and selenazolidinone derivatives (Z2B, Z2E, Z2B', Z2E') based on sulfonamide have been synthesized and characterized by different instrumental techniques, such as elemental analyses, FTIR, multinuclear NMR (1H, 13C) and mass spectrometry. The tested compound containing selenium (Z2E') was less toxic than its analogs containing sulfur (Z2E) based on the LD50 value determined by Dixon's up and down method. All compounds showed antibacterial properties, however, Z2E' was more active against Gram-negative bacteria: Escherichia coli and Pseudomonas aeruginosa than Gram-positive ones: Streptococcus aureus and Bacillus, with the lowest MIC value of 5 mg/mL. All compounds showed good antioxidant activity at a lower rate than the standard compound BHT (82%). More precisely, Z2b was the main compound that possess strong activity as an antioxidant (73%). MTT viability assay showed that all tested compounds had cytotoxic effects on MCF-7 cells after 72 h of treatment. Our results revealed that Z2E' and Z2E compounds possessed strong activity (IC50 = 24.8 and 90.9 µg/mL, respectively) against MCF-7 cells at a higher rate than the standard compound 5-FU (IC50 = 97.47 µg/mL). Our results indicated that Z2E' had a promising bioactive scaffold of great medicinal interest due to their numerous pharmacological and biological activities.

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Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, Antimicrobial, Antioxidant, Toxicity and Anticancer Activity of a New Azetidinone, Thiazolidinone and Selenazolidinone Derivatives Based on Sulfonamide

2022

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“…Inula graveolens (Dittrichia graveolens) is an annual plant that is sticky, strongly aromatic, and widely distributed in the Mediterranean area 1 . The essential oil and extracts of I. graveolens possess significant antioxidant, antiproliferative, and antibacterial activities, which have been demonstrated by pharmacological studies [2][3][4] . Previous phytochemical investigations of this plant have revealed the presence of oxygenated monoterpenes with high contents of bornyl acetate, borneol, and τ-cadinol 5 .…”

Section: Introductionmentioning

confidence: 96%

Inula graveolens induces selective cytotoxicity in glioblastoma and chronic leukemia cells

Koç

Aysin

Özek

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE: Crude oil extracts, components of extracts, and ethanolic extracts of Inula graveolens possess various pharmacological activities on various cancer cells including antioxidative and antiproliferative effects. Aqueous extract of this species has not been investigated on the liquid malignancies and solid tumors with a high incidence of treatment refractoriness and poor survival outcomes such as glioblastoma and leukemia. Hence, the present study aimed to evaluate the cytotoxic efficiency of I. graveolens aqueous extracts on human glioblastoma multiforme and chronic myelogenous leukemia cell lines in comparison to non-cancerous primary rat cerebral cortex and human peripheral blood mononuclear cells. METHODS:The cells were treated with the extracts of I. graveolens (125-1000 μg/mL) for 48 h, the cellular viability was identified using 3'-(4,5dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, and lactate dehydrogenase release was measured to determine the cytotoxic potential. Total oxidant status and apurinic/apyrimidinic endodeoxyribonuclease 1 assays were used to determine the oxidative status of cells and DNA damage, respectively. RESULTS: I. graveolens showed selective cytotoxicity toward human glioblastoma multiforme and chronic myelogenous leukemia cell lines and exhibited a higher antiproliferative effect against cancer cells in comparison to non-cancerous cells. Moreover, it significantly reduced the apurinic/apyrimidinic endodeoxyribonuclease 1 levels on both cancer cell lines as compared with their control cells without changing the levels of an oxidative stress marker. CONCLUSION:The extracts of I. graveolens have anti-cancer potential on human glioblastoma multiforme and chronic myelogenous leukemia cell lines without causing oxidative stress.

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Inula aucheriana'nın Antikanser, Antioksidan, Antimikrobiyal ve Enzim İnhibitör Aktiviteleri

Güçlü

Ergül

Uçar

et al. 2022

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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Inula aucheriana showing widespread in Turkey, it is a plant belonging to the Asteraceae family. It is aimed to reveal the pharmacological potential of this plant with this study, which investigates the different biological properties of this plant, which is known to be used in the treatment of various diseases. Methods: 80% ethanol extract of I.aucheriana was prepared and investigated the chemical composition (Q-TOF analysis), antioxidant (spectrophotometric analysis), enzyme inhibitory activities (Ellman's method), antimicrobial (MIC concentration value), anticancer (IC50 analysis) activities with qualitative and quantitative methods. Results: 80% ethanol extract of I.aucheriana was showed that is a powerful antioxidant, anticancer and enzyme inhibitor. In the chemical composition analysis, the major compound of the exctract was determined as luteolin (32.55%). I. aucheriana extract has been shown to have AChE and BChE inhibition. In addition, when the Inula extract was compared with the reference drug, it was determined that the extract had an inhibitory effect in terms of ɑ-glucosidase. It also showed quite high tyrosinase enzyme inhibition. When its antiproliferative activity was examined, it was found to be quite active in the MDA-MB-231 cell line. Conclusion: This study is the first investigation of the enzyme inhibitory activity and antioxidant activity of I. aucheriana. According to the data obtained from the study, more detailed studies can be conducted with the active ingredients of I. aucheriana, and promising results can be obtained for the treatment of different diseases.

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Antioxidant properties of methanolic extract from Inula graveolens L.

Cited by 10 publications

References 16 publications

Synthesis, Antimicrobial, Antioxidant, Toxicity and Anticancer Activity of a New Azetidinone, Thiazolidinone and Selenazolidinone Derivatives Based on Sulfonamide

Synthesis, Antimicrobial, Antioxidant, Toxicity and Anticancer Activity of a New Azetidinone, Thiazolidinone and Selenazolidinone Derivatives Based on Sulfonamide

Inula graveolens induces selective cytotoxicity in glioblastoma and chronic leukemia cells

Inula aucheriana'nın Antikanser, Antioksidan, Antimikrobiyal ve Enzim İnhibitör Aktiviteleri

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