Antioxidant properties of a<i>Tinospora cordifolia</i>polysaccharide against iron-mediated lipid damage and γ-ray induced protein damage

Subramanian, M. S.; Chintalwar, G. J.; Chattopadhyay, Subrata

doi:10.1179/135100002125000370

Cited by 83 publications

(48 citation statements)

References 23 publications

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“…Correa ex, [18][19] Bacopa monnieri, 20 Solanum nigrum Linn., 21 Plumbago zeylanica L., [22][23][24] Coriandrum sativum Linn., 25 Leucas aspera (Willd.) Link, 26 Tinospora cordifolia (Wild) Meirs., [27][28][29][30][31][32][33][34][35][36][37][38][39][40] Terminalia chebula Retz., 41 Premna integrifolia Linn., 42 Carum carvi L., 43 Piper longum L., [44][45][46][47][48][49] Centella asiatica Linn., [50][51] Cyperus rotundus L., 52 Vitex nirgundo L., 53 Nelumbo nucifera Gaertn., [54][55] Moringa oleifera Lam., [56][57] Cedrus deodara (Roxb.) Loud., 58 Acorus calamus L., 2 Boerhavia diffusa Linn., 59 Embelia ribes Burn F., 2 Citrullus colocynthis Schrad., 60 Terminalia bellerica (Gaertn.)…”

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2014

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Section: Discussionunclassified

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2014

IJPSR

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“…(RC) is considered to be traditionally useful as an external application in inflammations, ulcers and skin diseases, to relieve the symptoms of pruritis, burning and exudation from skin (Jorapurkar et al, 2003a,b). The antioxidant, anti-inflammatory and immuno-modulatory properties of TC and RC has also been well documented (Tripathi et al, 1997;Kasture et al, 2001;Bishayi et al, 2002;Subramanian et al, 2002). In light of the aforementioned antiinflammatory properties of TC and RC, it is hypothesized that these herbs may be helpful in reducing the antigen-induced conjunctivitis in rats via anti-histaminic activities since inflammatory mediators like histamine is also involved in allergy.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumin-induced experimental allergic conjunctivitis in rats

Zalawadia¹,

Chintan²,

Vaibhav³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYAllergic conjunctivitis is the most common allergic disease. These diseases are severe & frequent which requires search of new treatments. The aim of the study was to investigate the effects of Tinospora cordifolia (TC), Rubia cordifolia Linn. (RC) on experimentally induced allergic conjunctivitis in rats. In this study, dried water soluble extracts of TC and RC. (250 and 500 mg/kg, p.o. for 7 days) were evaluated for their antiallergic activity in Wistar rats. They were tested for inhibition of egg albumin-induced vascular permeability, inhibition of histamine release from the rat conjunctiva as well as in histamine content in tears. TC and RC showed significant (P < 0.05) inhibition in vascular permeability, inhibition in histamine release from the rat conjunctiva which is reflected by reduced level of histamine content in tears. The activities were found to be comparable to azelastine hydrochloride. These results suggest that the inhibitory effect on egg albumin-induced experimental allergic conjunctivitis in rat may be due to the antihistaminic activity of TC and RC. Our studies provide evidence that TC and RC may be beneficial in the treatment of allergic conjunctivitis.

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“…People have isolated a series of active ingredients from natural anti-radiation substances, such as polysaccharides (Subramanian et al, 2002;Song et al, 2003;Il´in et al, 2004;Fan et al, 2005) (Devi et al, 1998;Liu et al, 2002;Zielonka et al, 2003;, polyphenols (Hibasami et al, 2000;Lv et al, 2004), saponins (Chen et al, 1999;Kim et al, 2001;Li et al, 2001;Kuinar et al, 2003), alkaloids (Liang et al, 2002;Makarchenko and Utkina 2006 ), and peptides compounds (Zhu and Zhong 2004;Yang 2007), etc. Rosa roxburghii Tratt (Figure 1) is the fruit of jiao-si flower or unicuspid jiao-si flower from rosaceae, which was firstly recorded in the "ben-cao-gang-mu-shi-yi".…”

Section: Introductionmentioning

confidence: 99%

Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

Zhang²,

Cai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of 30 µg/mL. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.

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Antioxidant properties of aTinospora cordifoliapolysaccharide against iron-mediated lipid damage and γ-ray induced protein damage

Cited by 83 publications

References 23 publications

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Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumin-induced experimental allergic conjunctivitis in rats

Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

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