Antioxidant properties of 2,5-substituted 6H-1,3,4-thiadiazines promising for experimental therapy of diabetes mellitus

Kinetic Potentiometry as a Method for Studying the Interactions of Antioxidants with Peroxyl Radicals

“…The patterns are consistent with the literature data on the relatively low rates of the reaction of α-tocopherol with free radicals in aqueous media and the structural features of the interaction of sterically hindered phenols with radicals [ 26 , 27 ]. In addition, dependences of this type were registered for synthesized compounds used in the treatment of various diseases: derivatives of 6H-1,3,4-thiadiazines—newly synthesized compounds, promising antidiabetic drugs with pleiotropic activity (antioxidant and antiglycation) [ 22 ], which have a prolonged activity, and for compounds of the azoloazine series modified with polyphenolic antioxidant fragments that exhibit antiviral and antioxidant activity [ 21 ]. Figure 5 shows the kinetic dependences of the potential for thiadiazine (1AZ) and azoloazine (1TH) derivatives.…”

“…Thiadiazines are capable of transformation into substituted mercaptopyrazoles [ 31 ], which react with potassium hexacyanoferrate (III). At the same time, the rate of this transformation is low and, accordingly, the rate of the reaction with potassium hexacyanoferrate (III) is low for the thiadiazine derivatives [ 22 ]. This does not allow the correct determination of the residual concentration of thiadiazines in conditions of competing kinetics: the initiation of a radical reaction and the reaction of thiadiazines in potassium hexacyanoferrate (III).…”

“…The objects of the research were solutions of antioxidants of natural and synthetic origin: ascorbic acid, uric acid, glutathione, cysteine, catechol, gallic acid, chlorogenic acid, caffeic acid, α-tocopherol, 2,6-ditretbutylphenol, 2,6-ditretbutyl-4-methylphenol (ionol), and compounds of the azoloazine series modified with polyphenol antioxidant fragments ( Figure 1 ), as promising molecules for the creation of “double” action drugs [ 21 ]; derivatives of 6H-1,3,4-thiadiazines are newly synthesized compounds ( Figure 2 ), promising antidiabetic drugs with pleiotropic activity [ 22 ].…”