Antioxidant properties evaluation of topical astaxanthin formulations as anti‐aging products

Eren, Bi̇lge; Tanrıverdi, Sakine Tuncay; Köse, Fadime Aydın; Özer, Özgen

doi:10.1111/jocd.12665

Cited by 56 publications

(43 citation statements)

References 25 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…α‐tocopherol cream (N5) with the highest antioxidant activities showed the highest % cell proliferation. This result agrees with the findings of Chen et al (2016), Pitz et al (2016), and Eren et al (2018), who suggested the positive effect of antioxidant compounds in cell growth.…”

Section: Resultssupporting

confidence: 93%

Application of Kenaf Seed Oil‐Nanostructured Lipid Carrier to Palm‐Based α‐Tocopherol Cream for Photoprotection

Chu

Hasan

Tan

et al. 2021

J Americ Oil Chem Soc

View full text Add to dashboard Cite

The application of a nanostructured lipid carrier (NLC) to ultraviolet (UV) filter encapsulation was found to enhance its safe use. In this work, a kenaf seed oil‐NLC (KSO‐NLC) coloaded with 1% diethylamino hydroxybenzoyl hexyl benzoate and 1% ethylhexyl triazone was used as an active ingredient in α‐tocopherol cream to develop a photoprotective prototype. It was then subjected to further analysis to determine its physical properties, storage stability, and cytotoxicity. The ratio of KSO‐NLC to α‐tocopherol cream was optimized based on the sun protection factor (SPF) value using a UV transmittance analyzer. The physical properties of the samples were analyzed, and the amount of α‐tocopherol was quantified by ultra‐high‐performance liquid chromatography. The optimized sample was then evaluated for in vitro antioxidant activities using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid assays. Meanwhile, in vitro cytotoxicity was studied on a normal human dermal fibroblast cell line using thiazolyl blue tetrazolium bromide and cell counting kit‐8 assays. The sample of KSO‐NLC to α‐tocopherol cream in a ratio of 1:2 (N3) showed SPF value >50. Besides, the samples showed microbial stability and sustainable α‐tocopherol content upon 12 weeks of storage. The cytotoxicity evaluation of N3 and α‐tocopherol cream (N5) showed >100% cell proliferation, which indicated that there is no side effect on the cell growth, while triggering the cell proliferation with the presence of bioactive compounds. Overall, the findings of the study are promising for the development of new sunscreen formulation with the utilization of KSO‐NLC and palm‐based α‐tocopherol cream.

show abstract

Section: Resultssupporting

confidence: 93%

Application of Kenaf Seed Oil‐Nanostructured Lipid Carrier to Palm‐Based α‐Tocopherol Cream for Photoprotection

Chu

Hasan

Tan

et al. 2021

J Americ Oil Chem Soc

View full text Add to dashboard Cite

show abstract

“…Researchers studied the inhibition of oxidative injury of biological membranes by AST and found that its efficacy is higher than vitamin E, which is associated with the mitochondrial theory of aging [106]. This property highlights its unique potential to combat aging [4,107].…”

Section: Ast and Neurodegenerative Diseasesmentioning

confidence: 99%

The Neuroprotective Effects of Astaxanthin: Therapeutic Targets and Clinical Perspective

et al. 2019

View full text Add to dashboard Cite

As the leading causes of human disability and mortality, neurological diseases affect millions of people worldwide and are on the rise. Although the general roles of several signaling pathways in the pathogenesis of neurodegenerative disorders have so far been identified, the exact pathophysiology of neuronal disorders and their effective treatments have not yet been precisely elucidated. This requires multi-target treatments, which should simultaneously attenuate neuronal inflammation, oxidative stress, and apoptosis. In this regard, astaxanthin (AST) has gained growing interest as a multi-target pharmacological agent against neurological disorders including Parkinson’s disease (PD), Alzheimer’s disease (AD), brain and spinal cord injuries, neuropathic pain (NP), aging, depression, and autism. The present review highlights the neuroprotective effects of AST mainly based on its anti-inflammatory, antioxidative, and anti-apoptotic properties that underlies its pharmacological mechanisms of action to tackle neurodegeneration. The need to develop novel AST delivery systems, including nanoformulations, targeted therapy, and beyond, is also considered.

show abstract

“…As we mentioned in the previous section, astaxanthin is among the carotenoids considered to be a potent skin protective nutrient due to its natural capacity to protect cells from irradiation and oxidation, proven to prevent or minimize the signs of UVB-induced skin damage but also UVA-induced photoaging such as skin wrinkling or sagging by topical or oral administration routes [35,37,133,157]. Several human studies, which were later confirmed in animal studies [135,171], demonstrated that astaxanthin, in addition to improvement of the appearance of wrinkles, also improved skin elasticity, moisture, age spots, and skin texture [172,173]. In vitro studies have demonstrated that astaxanthin improves the function of mitochondria and has protective effects on human skin fibroblasts by exhibiting other biological functions rather than AO, including effects on gap junctional communication important for homeostasis, growth control, and development of cells [174].…”

Section: Carotenoids and Skin Agingmentioning

confidence: 99%

Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?

Balić

Mokos

2019

Antioxidants

View full text Add to dashboard Cite

Due to their potential health-promoting effects, carotenoids have drawn both scientific and public attention in recent years. The primary source of carotenoids in the human skin is diet, mainly fruits, vegetables, and marine product, but they may originate from supplementation and topical application, too. In the skin, they accumulate mostly in the epidermis and act as a protective barrier to various environmental influences. Namely, the skin is exposed to numerous environmental factors, including ultraviolet radiation (UVR), air pollution, and smoking, that cause oxidative stress within the skin with consequent premature (extrinsic) aging. UVR, as the most prominent environmental factor, may cause additional detrimental skin effects, such as sunburn, DNA damage, and skin cancer. Therefore, photoprotection is the first line intervention in the prevention of premature aging and skin cancer. Numerous studies have demonstrated that carotenoids, particularly β-carotene, lycopene, lutein, and astaxanthin, have photoprotective effects, not only through direct light-absorbing properties, but also through their antioxidant effects (scavenging reactive oxygen species), as well as by regulation of UV light-induced gene expression, modulation of stress-dependent signaling, and/or suppression of cellular and tissue responses like inflammation. Interventional studies in humans with carotenoid-rich diet have shown its photoprotective effects on the skin (mostly by decreasing the sensitivity to UVR-induced erythema) and its beneficial effects in prevention and improvement of skin aging (improved skin elasticity and hydration, skin texture, wrinkles, and age spots). Furthermore, carotenoids may be helpful in the prevention and treatment of some photodermatoses, including erythropoietic protoporphyria (EPP), porphyria cutanea tarda (PCT) and polymorphous light eruption (PMLE). Although UVR is recognized as the main etiopathogenetic factor in the development of non-melanoma skin cancer (NMSC) and melanoma, and the photoprotective effects of carotenoids are certain, available studies still could not undoubtedly confirm the protective role of carotenoids in skin photocarcinogenesis.

show abstract

Antioxidant properties evaluation of topical astaxanthin formulations as anti‐aging products

Abstract: Topical formulations of astaxanthin-loaded oleoresin and algae extract were prepared successfully. At the same time, according to antioxidant activity and release studies, algae extract loaded could be suggested as topical anti-aging formulations.

Cited by 56 publications

References 25 publications

Application of Kenaf Seed Oil‐Nanostructured Lipid Carrier to Palm‐Based α‐Tocopherol Cream for Photoprotection

Application of Kenaf Seed Oil‐Nanostructured Lipid Carrier to Palm‐Based α‐Tocopherol Cream for Photoprotection

The Neuroprotective Effects of Astaxanthin: Therapeutic Targets and Clinical Perspective

Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?

Contact Info

Product

Resources

About