Antioxidant properties and TLC characterization of four Chilean Haplopappus-species known as bailahuén

Vogel, Hermine; González, M. S.; Faini, Francesca; Razmilic, Iván; Rodrı́guez, Jaime A.; Martín, José San; Urbina, Francisco Zúñiga

doi:10.1016/j.jep.2004.10.027

Cited by 38 publications

(31 citation statements)

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“…8 Besides, these results were not consistent with our TLC analysis of the resinous extract of the species, where the presence of several flavonoid derivatives could be clearly detected. 4 In order to corroborate these preliminary results and in continuation with our survey on the bioactivity of the "bailahuen" cluster, we now report the results of anti-inflammatory and cytotoxic bioassays performed with a dichloromethane extract obtained from leaves of H. remyanus. The presence of four characteristic monoterpenes and seven flavonoids detected in the resinous exudate is discussed in terms of their effect on the medicinal properties attributed to this species.…”

Section: Obtained From Leaves Of H Baylahuen H Taeda H Multifolisupporting

confidence: 53%

“…The terpenoid mixture (T) was complex and after repeated column chromatography afforded six compounds (1)(2)(3)(4)(5)(6) (Table 1) showed that they were closely related monoterpenes. A comparison with reported data 5,7 for monoterpenes isolated from H. taeda and H. remyanus, easily identified 3 as 9-hydroxy-α-terpineol and suggested that 4-6 were benzoate esters of 3 with slight modifications in the main skeleton (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…In addition to these results, a high concentration of the bioactive flavanone pinostrobin 24 in the ecotype studied by Zdero et al 7 provides further support for the therapeutic uses of H. remyanus. The possible contribution of monoterpene derivatives (3)(4)(5)(6) to the bioactivity of the extract has yet to be established.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the previously reported high radical scavenging activity displayed by H. remyanus extract in the DPPH bioassay 4 can now be explained by the presence of flavonoids 7-11. 8 On the other hand, the anti-inflammatory activity in the ear edema bioassay, could arise in part from quercetin and kaempferol derivatives detected in this study, as well as the dihydroflavonoids, as reported in the literature.…”

mentioning

confidence: 83%

“…In order to find scientific support for the antispasmodic reputation of "bailahuen" species, we first compared the radical scavenging capacity (DPPH) of different types of extracts 4 …”

Section: Introductionmentioning

confidence: 99%

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Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant

Faini

Torres

Rodilla

et al. 2011

J. Braz. Chem. Soc.

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A cromatografia do extrato resinoso das partes aéreas de Haplopappus remyanus conduziu ao isolamento do ácido 18-acetoxilabda-7,13E-dien-15-óico, assim como dos derivados monoterpênicos 9-hidróxi-α-terpineol, 9-benzoilóxi-α-terpineol, 7-hidróxi-9-benzoilóxi-α-terpineol e 9-benzoilóxi-(1-formil)-α-terpineol. As estruturas para os novos compostos foram propostas com base em evidências espectroscópicas. A presença de quercetina e de outros cinco flavonóides conhecidos e identificados neste estudo pode ser responsável pela alta atividade antioxidante descrita e pelo moderado efeito tópico anti-inflamatório sobre edema de orelha induzido. Uma avaliação MTT com células tumorais CCRF-CEM mostrou 50% da atividade citotóxica exibida pela doxorubicina nas mesmas condições. Diferenças quantitativas na composição química foram detectadas em comparação com estudos prévios com a mesma espécie, as quais podem ser atribuídas a fatores ambientais.Chromatography on the resinous extract of aerial parts of Haplopappus remyanus led to the isolation of 18-acetoxy-labda-7,13E-dien-15-oic acid along with the monoterpene derivatives 9-hydroxy-α-terpineol, 9-benzoyloxy-α-terpineol,7-hydroxy-9-benzoyloxy-α-terpineol and 9-benzoyloxy-(1-formyl)-α-terpineol. Structures for the new compounds are proposed on spectroscopic evidence. The presence of quercetin and five other known flavonoids identified in this study could account for the reported high antioxidant activity and the moderate topic antiinflammatory effect on induced ear oedema. MTT assay with CCRF-CEM tumor cells showed 50% of the cytotoxic activity displayed by doxorubicin under the same conditions. Quantitative differences in chemical composition were detected in comparison with previous studies of the species that could be attributed to environmental factors.

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Section: Obtained From Leaves Of H Baylahuen H Taeda H Multifolisupporting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 83%

“…In order to find scientific support for the antispasmodic reputation of "bailahuen" species, we first compared the radical scavenging capacity (DPPH) of different types of extracts 4 …”

Section: Introductionmentioning

confidence: 99%

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Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant

Faini

Torres

Rodilla

et al. 2011

J. Braz. Chem. Soc.

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Quality Assessment of Herbal Drugs and Medicinal Plant Products

Ahmad

Khan

Cameotra

2014

Encyclopedia of Analytical Chemistry

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The herbal drugs and medicinal plant products have been widely used for thousands of years in many parts of the world. Medicinal plants constitute a source of raw material for both traditional and modern systems of medicine. In recent few decades, growth and popularity of herbal medicine and plant products have taken a significant share of the healthcare. Various systems of traditional medicines have been recognized in many countries such as India, Japan, Korea, China, USA, and some European countries. Each country has its own set of guidelines to assess the quality control of the herbal medicine depending on the system they adapt to prepare herbal medicine. The importance of quality control and standardization of botanical products is of utmost concern for global acceptability of these drugs in the modern system of medicine. These assessments are needed at different levels of drug‐manufacturing processes and post‐manufacturing stages. As herbal medicinal products are complex mixtures that originate from biological sources, great efforts are necessary to guarantee a constant and adequate quality. The morphological and microscopic identifications are utilized to determine the authenticity of herbal medicines, and the physical and chemical characters are used to evaluate the quality of herbs in the existing quality standards. The fingerprint analyses have been internationally accepted as one of the efficient methods to control the quality of herbal medicines. In addition to fingerprinting, other parameters such as microbiological and chemical contaminations, adulterants, and toxicity including genotoxicity are to be assessed. In this chapter, the current scenario of the quality control assessment of herbal medicine and medicinal plant products is reviewed. Botanical parameters such as sensory or organoleptic evaluation, histological observations and measurements are discussed. An overview covering various techniques employed in quantitative characterization of herbal medicines such as thin layer chromatography (TLC), high performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), and infrared (IR) spectroscopy is reported. Potential of metabolomics in the developments of improved phytotherapeutic agents, and DNA‐based molecular markers in adulterants, is described. Pharmacological and toxicological parameters such as pesticide residue, heavy metals, aflatoxins, and microbial and radioactive contaminations are also addressed.

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Authenticating and distinguishing the eight species of traditional Tibetan medicine “Meiduoluomi” by microscopic technique

Wang

et al. 2009

Microscopy Res & Technique

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Because of the morphological and macroscopic similarity, many species of Erigeron and Aster (Asteraceae) are confusable and usually used under the same name "Meiduoluomi" in traditional Tibetan medicine (TTM). To find an easy, quick, and reliable method to authenticate and distinguish the eight main medicinal plants of these species, the light microscope was used to reveal the morphoanatomic details. The fixed, sectioned, and stained plant materials and epidermis materials were studied by microscopic techniques. The results of the microscopic features are systematically described and illustrated, and comparison parameters are presented. Furthermore, a key to the eight species of "Meiduoluomi" was constructed. Microscopy can be unambiguously used to authenticate and distinguish the eight main species of TTM "Meiduoluomi."

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Antioxidant properties and TLC characterization of four Chilean Haplopappus-species known as bailahuén

Cited by 38 publications

References 11 publications

Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant

Chemistry and bioactivity of Haplopappus remyanus ("bailahuen"), a chilean medicinal plant

Quality Assessment of Herbal Drugs and Medicinal Plant Products

Authenticating and distinguishing the eight species of traditional Tibetan medicine “Meiduoluomi” by microscopic technique

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