Antioxidant properties and hepatoprotective effect of the edible halophyte Crithmum maritimum L. against carbon tetrachloride-induced liver injury in rats

Nutraceutical Potential of Leaf Hydro-Ethanolic Extract of the Edible Halophyte Crithmum maritimum L.

“…Thus, C. maritimum leaves contained 31.7 mg GAE g −1 DW of polyphenols and 25.6 mg CE g −1 DW of flavonoids, including 17.3 mg QE g −1 DW of flavonols. The hydro-ethanolic extract exhibited a higher concentration of total polyphenols compared to that found before in acetonic or methanol extracts of the same species sampled at the same place [ 6 ]. Accordingly, the amount of these phytochemicals has been shown to vary significantly depending on the extraction solvent [ 8 , 16 , 17 , 18 ].…”

“…Amongst bioactive molecules-bearing plants, the halophytes are recognised as a source of constituents with both medicinal and nutritional value [ 5 ]. In the last decades, there has been an increasing use of halophytic plants, including Salicornia herbacea , Inula crithmoides , Portulaca oleracea and Crithmum maritimum , as non-conventional foods [ 2 , 6 , 7 , 8 ].…”

Suaeda vermiculata Aqueous-Ethanolic Extract-Based Mitigation of CCl4-Induced Hepatotoxicity in Rats, and HepG-2 and HepG-2/ADR Cell-Lines-Based Cytotoxicity Evaluations

“…Nonetheless, the use of medicinal plants and their extracts as alternative sources for prophylactic and therapeutic hepatoprotection has always been intriguing, though it has been practiced commonly by traditional healers over time. The majority of the ameliorating claims regarding the hepatoprotective plants, and herbal formulations, remain unproven, vague, and scientifically unsubstantiated, although efforts are still continuously being pushed into the area, and newer plants from varying environments and climatic-condition origins, together with improved testing protocols, are ceaselessly being adopted constantly into the realm of hepatoprotection strategies at global scales [ 8 , 9 , 10 , 11 ].…”

“…Halophytic plants, growing under high-salinity soil conditions, have also been recorded to provide relief from symptomatic liver discomforts [ 8 , 9 , 10 ]. The halophytes, under the stress of harsh super-saline habitats in areas with the lowest rainfall and marshy conditions, as well as desert environments, have accustomed to adverse environmental conditions through developing various defense mechanisms for survival.…”

“…The oral supplementation of antioxidants for liver disorders has been studied, and several non-enzymatic antioxidants, (e.g., ascorbic acid, α-tocopherol, silibinin, naringenin, quercetin, curcumin, resveratrol, products of phenolic, flavonoid, tannin, and carotenoid types) have been exploited [ 21 , 22 , 23 ], and the plant-origin secondary metabolite-based antioxidants have revealed promising in vivo therapeutic effects on liver disorders in studied animal models [ 24 ], though clinical studies were deemed inconclusive [ 23 ]. However, the protective roles of these antioxidants on the liver, in experimentally induced-liver injury and toxication, have been investigated for various pure, single component natural products, and on the naturally-sourced plants’ extracts, as well as mixtures of synergistic natural products containing antioxidants of a structurally-varied chemical nature, and were found to be effective [ 9 , 25 , 26 , 27 , 28 ].…”