Antioxidant profile in patients with complex regional pain syndrome type I

Baykal, Tuba; Seferoglu, B.; Karsan, Orhan; Kızıltunç, Ahmet; Şenel, Kazım

doi:10.1111/1756-185x.12140

Cited by 13 publications

(11 citation statements)

References 13 publications

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“…Abnormalities in plasma levels of various amino acids 48 , antioxidants 49 and circulating CD14 + CD16 + monocytes 50 have also been described in CRPS, but unfortunately in studies that did not include appropriate pain control groups. Therefore, the utility of these factors as biomarkers for CRPS remains to be determined.…”

Section: Diagnostic Features and Biomarkersmentioning

confidence: 99%

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

et al. 2018

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Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single limb, often following an injury. The underlying pathophysiology seems to be complex and probably varies between patients. Clinical diagnosis is based on internationally agreed-upon criteria, which consider the reported symptoms, presence of signs and exclusion of alternative causes. Research into CRPS biomarkers to support patient stratification and improve diagnostic certainty is an important scientific focus, and recent progress in this area provides an opportunity for an up-to-date topical review of measurable disease-predictive, diagnostic and prognostic parameters. Clinical and biochemical attributes of CRPS that may aid diagnosis and determination of appropriate treatment are delineated. Findings that predict the development of CRPS and support the diagnosis include trauma-related factors, neurocognitive peculiarities, psychological markers, and local and systemic changes that indicate activation of the immune system. Analysis of signatures of non-coding microRNAs that could predict the treatment response represents a new line of research. Results from the past 5 years of CRPS research indicate that a single marker for CRPS will probably never be found; however, a range of biomarkers might assist in clinical diagnosis and guide prognosis and treatment.

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Section: Diagnostic Features and Biomarkersmentioning

confidence: 99%

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

et al. 2018

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“…Furthermore, under normal conditions, the antioxidant defense system neutralizes excess free radicals to prevent damage [42][43][44]. While oxidative stress has been associated to painful conditions [26,[45][46][47][48], the direct link is not yet understood. It is hypothesized that oxidative stress contributes to pain by exacerbating pathological responses like inflammation and neuropathy, which both contribute to pain.…”

Section: Oxidative Stress and Painmentioning

confidence: 99%

Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation

2020

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Chronic pain is highly prevalent in the United States, impacting 28.4% of the adult population, or 69.6 million people, as of 2016. Chronic pain is often associated with anxiety, depression, and restrictions in mobility and daily activities, substantially reducing quality of life. Analgesics, especially opioids, are one of the primary pharmaceutical treatment methods for chronic pain. However, prescription opioid misuse and abuse has become increasingly prevalent and concerning, prompting the need for research into alternative treatment methods which avoid the side effects of traditional treatments. Chronic pain is, in part, thought to be the result of oxidative stress and inflammation, and clinical research has indicated links between these conditions and diet. Thus, dietary interventions are a particularly promising therapeutic treatment for chronic pain, with numerous studies suggesting that diet has a noticeable effect on pain as far down as the cellular level. In this review article, data from a number of clinical trials assessing the effect of three diets-antioxidant-rich, low-carbohydrate, and Mediterranean-on oxidative stress and inflammation is compiled and discussed in the context of chronic pain. Clinical data suggests that low-carbohydrate diets and Mediterranean diets both are especially promising dietary interventions.

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“…Several lines of evidence from human studies suggest oxidative stress in the limbs of patients with CRPS. [61][62][63] Nociceptive sensitization and elevated markers of oxidative stress have been noted in the limbs of laboratory animals used with either the ischemia-reperfusion or the tibial fracture model of CRPS, changes that can be reduced by the administration of antioxidant drugs like N-acetyl cysteine and vitamin C. 50,64 Using the tibial fracture model, it was observed that oxidative stress caused the upregulation of SP and CGRP that in turn were critical for the production of inflammatory cytokines (IL-6) and the pain-related neurotrophin NGF. 50 While the most extensive data regarding inflammation and cytokine production in CRPS pertain to skin, muscle, and joints, elevations in cytokine production in spinal cord tissue have been noted as well after fracture and cast immobilization.…”

Section: Autoinflammation and Crps (Cytokine Production)mentioning

confidence: 99%

Autoinflammatory and autoimmune contributions to complex regional pain syndrome

et al. 2018

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Complex regional pain syndrome (CRPS) is a highly enigmatic syndrome typically developing after injury or surgery to a limb. Severe pain and disability are common among those with chronic forms of this condition. Accumulating evidence suggests that CRPS may involve both autoinflammatory and autoimmune components. In this review article, evidence for dysfunction of both the innate and adaptive immune systems in CRPS is presented. Findings from human studies in which cytokines and other inflammatory mediators were measured in the skin of affected limbs are discussed. Additional results from studies of mediator levels in animal models are evaluated in this context. Similarly, the evidence from human, animal, and translational studies of the production of autoantibodies and the potential targets of those antibodies is reviewed. Compelling evidence of autoinflammation in skin and muscle of the affected limb has been collected from CRPS patients and laboratory animals. Cytokines including IL-1β, IL-6, TNFα, and others are reliably identified during the acute phases of the syndrome. More recently, autoimmune contributions have been suggested by the discovery of self-directed pain-promoting IgG and IgM antibodies in CRPS patients and model animals. Both the autoimmune and the autoinflammatory components of CRPS appear to be regulated by neuropeptide-containing peripheral nerve fibers and the sympathetic nervous system. While CRPS displays a complex neuroimmunological pathogenesis, therapeutic interventions could be designed targeting autoinflammation, autoimmunity, or the neural support for these phenomena.

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Antioxidant profile in patients with complex regional pain syndrome type I

Abstract: Our findings suggest a possible role of oxidative stress in the pathogenesis of CRPS.

Cited by 13 publications

References 13 publications

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation

Autoinflammatory and autoimmune contributions to complex regional pain syndrome

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