Antioxidant Principle of the Dry Aqueous Leaf Extracts of Cnidoscolus aconitifolius on Ethanol–induced Biochemical Changes in the Plasma and Brain Tissue of Rabbits

The Effects of the Aqueous, Ethanol and Hexane Extracts of Cnidoscolus aconitifolius Leaf on the Hematological Indices and Liver Histological Status of Streptozotocin-induced Diabetic Rats

“…This may be possible because bioactive ingredients are effectively expressed from plant materials based on their solubility in the extracting solvent. Based on the phytochemical screening of the dried aqueous extract of Cnidoscolus aconitifolius documented by Mordi and Akanji (2012), the high content of phlobatannin and saponin must have acted synergistically as antioxidants cushioning the diabetic consequences as revealed by the histological slides. Hence, the scientific rationale in the use of Cnidoscolus aconitifolius as antidiabetic agent was confirmed in this study; however further targeted investigations to unveil the chemical structure of the bioactive molecule, their mechanisms of action and molecular disposition.…”

“…C. aconitifolius informally alludes as Chaya (Donkoh, et al, 1990). Several ethnic groups or locality in Nigeria has called Cnidoscolus aconitifolius different names such as "efo Iyana Ipaja"; but its traditional nomenclature and usefulness is based on its therapeutic potential, aesthetic properties, nutritional values and perhaps method of extraction (Mordi 2012;Mordi and Akanji, 2012). With the high negligence and underutilization of native herbs such as Cnidoscolus aconitifolius, insight into the mycobiota of Cnidoscolus aconitifolius phyllosphere is a springboard to yield proliferation and pathogenic species combat thereby enhancing the availability of the plant species to the growing populace (Ogbuji and Ataga, 2022) Several folk claims have been attributed to the medicinal efficacy of C. aconitifolius for the treatment or management of numerous health complications and ailments.…”