Antioxidant potentials of furanodihydrobenzoxanthones from Artocarpus elasticus and their protection against oxLDL induced injury in SH-SY5Y cells

Baiseitova, Aizhamal; Shah, Abdul Bari; Khan, Abdul Majid; Idrees, Muhammad; Kim, Jeong-Ho; Lee, Yong Hyun; Kong, Il-Keun; Park, Ki Hun

doi:10.1016/j.biopha.2023.115278

Cited by 11 publications

(8 citation statements)

References 31 publications

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“…This shows that phenolics (mainly flavonoids) make a very noticeable contribution to the DPPH scavenging activity in the CWR samples. It is known that polyphenolic compounds can enhance strong antioxidant activities against DPPH radicals. , In the wolffia filtrate, the BWF had the highest (66.46%) DPPH scavenging activity, followed by those of the CWF and TWF samples, 47.46 and 28.17%, respectively.…”

Section: Resultsmentioning

confidence: 96%

“…It is known that polyphenolic compounds can enhance strong antioxidant activities against DPPH radicals. 38,39 In the wolffia filtrate, the BWF had the highest (66.46%) DPPH scavenging activity, followed by those of the CWF and TWF samples, 47.46 and 28.17%, respectively. The ABTS and FRAP antioxidant activities exhibited no significant differences, as illustrated in Figure 1B,C, respectively.…”

Section: Effect Of Cell Wall Ruptures Methods On Antioxidant Activiti...mentioning

confidence: 99%

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Characterization of Bioactive Metabolites and Antioxidant Activities in Solid and Liquid Fractions of Fresh Duckweed (Wolffia globosa) Subjected to Different Cell Wall Rupture Methods

Yadav,

Patel,

Debbarma

et al. 2024

ACS Omega

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Fresh Wolffia globosa, the smallest flowering plant well-known for its favorable nutrient composition and rich content of bioactive compounds, was subjected to boiling, freeze−thawing, and mechanical crushing to reduce its excessive (95−96%) moisture level and consequent drying time. The resultant three wolffia matrixes were filtered through a plankton net to fractionate into the residue and the filtrate. The proximate composition, bioactive metabolites, antioxidant activity, and characterization of bioactive metabolites by LC-ESI-QTOF-MS/MS and Fourier transform infrared spectroscopy were made from oven-dried residues and filtrates. Among residues, crude protein (29.84%), crude lipid (5.77%), total carotenoids (TCC; 722.8 μg/g), and vitamin C (70.02 mg/100 g) were the highest (p < 0.05) for freeze−thawing against higher ash (7.99%), total phenolic content (TPC; 191.47 mg GAE g −1 dry weight), total flavonoid content (TFC; 91.54 mg QE g −1 dry weight), DPPH activity (47.46%), and ferric reducing antioxidant power (FRAP) activity (570.19 μmol FeSO 4 equiv/mg) for the crushed counterpart and Chl-b in residues from boiling. No significant variation was evident in the total tannin content (TTC). Among filtrates, higher total phenolic content (773.29 mg GAE g −1 dry weight), TFC (392.77 mg QE g −1 dry weight), TTC (22.51 mg TAE g −1 ), and antioxidant activity as DPPH activity (66.46%) and FRAP (891.62 μmol FeSO 4 equiv/mg) were evident for boiling, while that from crushing exhibited the highest TCC (1997.38 μg/g DM). LC-ESI-QTOF-MS/MS analysis identified 72 phenolic compounds with the maximum in residue (33) and filtrate (33) from freeze−thawing, followed by crushing (18 and 19) and boiling (14 and 13) in order, respectively. The results indicated that the predrying cell rupturing method significantly impacted quantitative, as well as qualitative compositions of residues and filtrates from fresh wolffia.

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Section: Resultsmentioning

confidence: 96%

Section: Effect Of Cell Wall Ruptures Methods On Antioxidant Activiti...mentioning

confidence: 99%

Characterization of Bioactive Metabolites and Antioxidant Activities in Solid and Liquid Fractions of Fresh Duckweed (Wolffia globosa) Subjected to Different Cell Wall Rupture Methods

Yadav,

Patel,

Debbarma

et al. 2024

ACS Omega

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“…Their structures (as shown in Figure 1) were elucidated by their spectroscopic data (Figures S1−S49 and Table S1) and compared with those of previous reports. The isolates (3−13) were identified as artoscortonol 19 (3), glepidotin B 20 (4), yukovanol 21 (5), dihydrokaempferol 22 (6), atalantoflavone 23 (7), apigenin 24 (8), 2′-hydroxyatalantoflavone 25 (9), norartocarpetin 10 (10), engeletin 26 (11), isoengeletin 26 (12), and apigenin-7-O-β-D-glucopyranoside 27 (13). Compounds 1 and 2 were found to be new dihydroflavonols.…”

Section: Results and Discussionmentioning

confidence: 99%

“…This study explored PTP1B inhibitory metabolites from the leaves of Artocarpus elasticus. The responsible metabolites for PTP1B (IC 50 = 0.17−35.41 μM) were identified as eight dihydroflavonols (1−6, 11, 12) and five flavones (7)(8)(9)(10)13). Inhibitory potency and behavior were significantly affected by chemical skeleton and functionality.…”

Section: Conclusionmentioning

confidence: 99%

“…The most abundant metabolites in both these parts were found to be prenylated flavonoids and dihydrobenzoxanthones with diverse biological activities. For example, the prenylated flavonoids showed antioxidant, cytotoxic, tyrosinase, and 5-α reductase inhibitory activities, while dihydrobenzoxanthones exhibited α-glucosidase, human neutrophil elastase, and bacterial neuraminidase inhibitory activities. − The ripened leaves of terap are dried, grounded, and used for preparing tea, which is effective in preventing chronic diseases such as diabetes, hypertension, and malaria. − But there are only two influential reports about their metabolites, which deal with alkylated dihydrochalcones. , Those compounds were not effective for PTP1B inhibition in our preliminary work. This encouraged us to conduct metabolite investigation targeting PTP1B inhibition.…”

Section: Introductionmentioning

confidence: 99%

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Analogues of Dihydroflavonol and Flavone as Protein Tyrosine Phosphatase 1B Inhibitors from the Leaves of Artocarpus elasticus

Shah,

Baiseitova,

Lee

et al. 2024

ACS Omega

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Protein tyrosine phosphatase 1B (PTP1B) is one of the target enzymes whose disruption leads to obesity and diabetes. A series of PTP1B inhibitors were isolated from the leaves of Artocarpus elasticus, used in traditional medicines for diabetes. The isolated inhibitors (1−13), including two new compounds (1 and 2), consisted of dihydroflavonols and flavones. The structural requirements for the PTP1B inhibitory mode and potency were revealed in both skeletons. The two highest PTP1B inhibitory properties were dihydroflavonol 1 and flavone 6 analogs with IC 50 values of 0.17 and 0.79 μM, respectively. The stereochemistry also affected inhibitory potencies: trans isomer 1 (IC 50 = 0.17 μM) vs cis isomer 2 (IC 50 = 2.24 μM). Surprisingly, the dihydroflavonol and flavone glycosides (11 and 13) displayed potent inhibition with IC 50 s of 2.39 and 0.22 μM, respectively. Furthermore, competitive inhibitor 1 was applied to time-dependence experiments as a simple slow-binding inhibitor with parameters of K i app = 0.064103 μM, k 3 = 0.2262 μM −1 min −1 , and k 4 = 0.0145 min −1 . The binding affinities by using the fluorescence quenching experiment were highly correlated with inhibitory potencies: 1 (IC 50 = 0.17 μM, K SV = 0.4375 × 10 5 L•mol −1 ) vs 3 (IC 50 = 17.79 μM, K SV = 0.0006 × 10 5 L•mol −1 ). The specific binding interactions were estimated at active and allosteric sites according to the inhibitory mode by molecular docking.

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Aspergillus awamori: potential antioxidant, anti-inflammatory, and anti-apoptotic activities in acetic acid-induced ulcerative colitis in rats

Abd-Ellatieff,

Georg,

Abourawash

et al. 2024

Inflammopharmacol

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Ulcerative colitis (UC) is a chronic colonic inflammation with a significant health hazard. Aspergillus awamori (A. awamori) is a microorganism with various bioactive compounds with natural antioxidant and anti-inflammatory properties. The present work aimed to elucidate the protective and therapeutic effects of varying concentrations of A. awamori against acetic acid (AA)-induced ulcerative colitis (UC) in rats. Nine groups of albino male rats were established: a control negative group (G1), a control positive group (G2,AA), and preventive protocol groups (including G3A, G4A, and G5A) that received 100 mg, 50 mg, and 25 mg/kg b.w, respectively, of A. awamori orally and daily from the 1st day of the experiment and for 7 consecutive days. Then, they were subjected to one dose of AA intrarectally on day 8th. G3B, G4B, and G5B were termed as curative protocol groups that received one dose of AA on day 8th and then administered 100 mg, 50 mg, and 25 mg/kg b.w. of A. awamori, respectively, on day 9th and continued receiving these doses daily until day 16th. Rats in the AA group exhibited marked histopathological alterations of the distal colon, with an exaggeration of the DAI. In addition, a remarkable increase in oxidative stress was represented by the elevation of MDA and NO levels with a decline in SOD and GPx activities. In addition, upregulation of TNF-α, IL-6, and IL-1β mRNA expressions and downregulation of Muc2 and Nrf2 levels were detected. Unambiguously, a remarkable anti-inflammatory effect was noticed either in A. awamori prevented or treated groups expounded by reducing and regulating TNF-α, IL-6, and IL-1β with improved pathological lesion scoring. The Muc2, Nrf2, and bcl-2 gene levels were upregulated and restored also. In summary, the findings in this work reveal that A. awamori supplementation successfully alleviated the UC induced by AA, which had a better effect when administered before colitis induction.

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Antioxidant potentials of furanodihydrobenzoxanthones from Artocarpus elasticus and their protection against oxLDL induced injury in SH-SY5Y cells

Cited by 11 publications

References 31 publications

Characterization of Bioactive Metabolites and Antioxidant Activities in Solid and Liquid Fractions of Fresh Duckweed (Wolffia globosa) Subjected to Different Cell Wall Rupture Methods

Characterization of Bioactive Metabolites and Antioxidant Activities in Solid and Liquid Fractions of Fresh Duckweed (Wolffia globosa) Subjected to Different Cell Wall Rupture Methods

Analogues of Dihydroflavonol and Flavone as Protein Tyrosine Phosphatase 1B Inhibitors from the Leaves of Artocarpus elasticus

Aspergillus awamori: potential antioxidant, anti-inflammatory, and anti-apoptotic activities in acetic acid-induced ulcerative colitis in rats

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