Antioxidant Potential Profile of Pajanelia Longifolia (Willd.) K. Schuman.; Potential New Sources of Natural Antioxidant.

Abstract

Objectives: The aim of the present work is to screen the antioxidant potentiality of the bark extracts of Pajanelia longifolia (Willd.) K. Schuman, ethnomedicinally prescribed plant as hepatoprotective.Methods: Bark extract was prepared using Soxhlet apparatus. Total phenol, flavonoid, total alkaloid were analyzed using Folin-Ciocalteu assay, aluminum chloride calorimetric assay, atropine standard, respectively. Antioxidant capacity and free radical scavenging potentialities were done by various in vitro methods, viz.; 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide scavenging activity, reducing power assay, metal chelating activity, ferric reducing antioxidant power (FRAP) assay, and thiobarbituric acid (TBA) method.Result: Total phenol, flavonoid, and alkaloid were found to be highest in acetone extract of P. longifolia (Willd.) K. Schuman. Acetone extracts of the bark of P. longifolia (Willd.) K. Schuman showed very low inhibitory concentration 50 (IC 50 ) and effective concentration 50 (EC 50) values for DPPH assay and reducing power assay compared to other extracts. In hydrogen peroxide scavenging activity assay, the lowest IC 50 value was recorded in acetone extract with 181.78±0.09 µg/ml in P. longifolia. The FRAP assay for P. longifolia acetone extract showed the highest activity at 967±0.69 μg/ml of ascorbic acid equivalent. The ferric reducing capacity and TBA values of the plant extracts confirmed the presence antioxidant principles in the bark of the said plant. Conclusion:These underused plant may be used for mitigating the detrimental effect of oxidative stress and reactive oxygen species-mediated disease and thus justifies its use in folklore medicines.

The efficacy of Pajanelia longifolia (Willd.) K. Schum leaf extracts against the malaria vector Anopheles stephensi Liston (Diptera: Culicidae)

“…longifolia is a small to medium tree that is either evergreen or deciduous and belongs to the Bignoniaceae family. They can be found at heights of up to 1000 meters above sea level in the deciduous and semi-evergreen highland rainforests of India, Sri Lanka, Myanmar, Thailand, Malaysia, the Peninsula, Sumatra, and Borneo (8). The plant is high in secondary metabolites that have medicinal value.…”

“…Leaf extracts containing polar components were found to have antibacterial activity (10,11). The plant's bark powder extract has antioxidant and antimicrobial properties (8,12). As a result, no experimental data on the validation of P. longifolia's anti-mosquito properties are available.…”

Amelioration of Acetaminophen-Induced Hepatotoxicity Using Solanum Torvum Sw. Fruit Extract in Wistar Rats

“…S. torvum Sw. fruit extract may contain antioxidant compounds or a free radical scavenger as it reduces lipid peroxidation and induces antioxidant status. It is known that some flavonoids are able to reduce xenobiotic-induced hepatotoxicity in animals [19]. The inhibitory activity of flavonoids on free radical production could be related to their hepatoprotective effects since exogenous antioxidants may counteract the damaging effects of oxidative stress, cooperating with natural systems such as GSH or protective enzymes.…”

Study of antibacterial, anti-proliferative and pro-apoptotic potential of the cell extracts of endophytic fungi and bacteria isolated from Pajanelia longifolia (Willd.) K. Schuman

“…The scientific interventions have reported antioxidant, hepatoprotective and cytotoxic activity of the plant (8,9). Many important metabolites from the P. longifolia, have been isolated and studied over a long time for medicinal properties such as antibacterial, antifungal, anti-tumour, immunosuppressant, anti-parasitic and antiviral, antioxidant and anti-inflammatory (10,11).…”