Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes

Piovezan-Borges, A. C.; Valério-Júnior, C.; Gonçalves, Itamar Luís; Mielniczki-Pereira, Albanin Aparecida; Valduga, Alice Teresa

doi:10.1590/1519-6984.01115

Cited by 20 publications

(17 citation statements)

References 15 publications

(11 reference statements)

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“…All of these results show a relation to the antioxidant potential of Ilex paraguariensis, which is widely described in the literature [ 2 , 3 , 36 , 37 , 38 , 39 ], even after the microencapsulation process [ 40 , 41 , 42 ]. In addition, the efficiency of the encapsulation process of Ilex paraguariensis is considered stable with the wall product used (maltodextrin gum Arabic).…”

Section: Discussionsupporting

confidence: 58%

“…This plant is used to prepare, through the infusion of its dried and ground leaves, the mate tea, called “chimarrão” in southern South America. The ingestion of herb mate extracts has the potential to increase the antioxidants in the system, reducing free radical attacks [ 2 ]. This plant has great antioxidant potential due to the presence of polyphenols, which constitute about 11% of the dry matter weight [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

et al. 2022

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Ilex paraguariensis (Herb mate) is a native plant from South America, widely consumed through the infusion of dried leaves. The presence of antioxidant properties in herb mate may be relevant and contribute to evaluating the effect of its compounds against oxidative stress, which could cause neurodegenerative diseases. Despite having health benefits, there are reports of the presence of heavy metals in extracts obtained from the infusion. One of these metals is iron (Fe), found in large amounts in herb mate. To reverse the cumulative effects of metals and Fe in the body, the use of Deferoxamine (Dfx) is indicated, being a potent chelator of Fe. In this work, we aimed to evaluate the antioxidant potential of the micro-encapsulated extract of I. paraguariensis (MEIP) supplemented with Dfx on zebrafish behavior and biochemical biomarkers. To evaluate the effect per se and the supplementation, four groups were established: the first group was the control (water); the second, fish treated with MEIP; the third group was formed of fish treated with Dfx; while the fourth group was treated with both MEIP and Dfx. When applied alone, Dfx presents an anxiogenic-like pattern on zebrafish (Danio rerio), while the MEIP shows an anxiolytic-like behavior. The antioxidant enzymes are re-modulated close to control when the MEIP + Dfx is applied. The cholinergic system shows an activation of the signaling, as well as the heme radical group formation, which is not affected by the Dfx-chelating effect. Thus, the supplementation of MEIP with Dfx is important to transform this extract into one that is safer and healthier for human consumption.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

et al. 2022

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“…The yerba mate is associated with numerous health benefits among which it is important to mention its antioxidant properties [3,4] vasodilators properties [5,6], hypoglycemic effects [7,8] and fat loss properties [9]. Different chemical components responsible for the yerba matebased beverages' positive health outcomes have been identified, such as vitamins, minerals, polyphenols, xanthines, saponins, phenolic compounds, amino acids, enzymes, cellulose, lignin and organic acids [10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)

Kungel

Corrêa

et al. 2018

International Journal of Biological Macromolecules

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This study investigated the antioxidant, antimicrobial and cytotoxic properties of a purified yerba mate polysaccharide. The yerba mate polysaccharide showed a prominent antioxidant activity as evaluated by 2,2-diphenyl-1picrylhydrazyl (DPPH•)-radical scavenging activity (IC 50 = 1.25 ± 0.10 mg/mL), 3-ethyl benzothiazoline-6sulphonic acid (ABTS•+)-radical scavenging activity (IC 50 = 0.41 ± 0.05 mg/mL), and hydroxyl scavenging activity (IC 50 = 3.36 ± 0.31 mg/mL). The antioxidant activity evaluated as the ferric ion reduction power (FRAP) and oxygen radical absorbance radical assay (ORAC), expressed as trolox equivalents, were 20.84 ± 1.61 μM TE/mg and 556.30 ± 12.83 μM TE/mg, respectively. The purified yerba mate polysaccharide presented high antimicrobial activity against several bacterial and fungal strains; however, no cytotoxicity against all four tumor human cell lines assessed.

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“…The yerba mate (YM) ( I. paraguariensis ) powdered stems and leaves are utilized as additives for stimulant drinks [60] due to YM’s health virtues, including the antimicrobial and antioxidant properties [61] of the purified polysaccharide [62]. The structure of the YM purified polysaccharide is RG-I.…”

Section: Outline Of Biological Activities Of Pectic Polysaccharidesmentioning

confidence: 99%

Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review

et al. 2018

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Pectin is a polymer with a core of alternating α-1,4-linked d-galacturonic acid and α-1,2-l-rhamnose units, as well as a variety of neutral sugars such as arabinose, galactose, and lesser amounts of other sugars. Currently, native pectins have been compared to modified ones due to the development of natural medicines and health products. In this review, the results of a study of the bioactivity of pectic polysaccharides, including its various pharmacological applications, such as its immunoregulatory, anti-inflammatory, hypoglycemic, antibacterial, antioxidant and antitumor activities, have been summarized. The potential of pectins to contribute to the enhancement of drug delivery systems has been observed.

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Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes

Cited by 20 publications

References 15 publications

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

Antioxidant and antimicrobial activities of a purified polysaccharide from yerba mate (Ilex paraguariensis)

Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review

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