Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice

Sinha, Dona; Roy, Somnath; Roy, Madhumita

doi:10.1016/j.fct.2010.01.016

Cited by 56 publications

(30 citation statements)

References 24 publications

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“…Similar increases in serum transaminases have been reported in workers exposed to high arsenic concentrations [54]. Our results explored the significant changes of lipid profile in arsenictreated rats, and this correlates with hyperlipidemic condition where oxidative stress may be one of the major contributors, and this hyperlipidemic condition may also play a crucial role to develop hepatic disorders [55,56]. Metabolic processing of arsenical compounds is related to the production of free radicals and reactive oxygen species [15,16] which ultimately results in DNA strand breakage [17].…”

Section: Discussionsupporting

confidence: 77%

Protective Role of Moringa oleifera (Sajina) Seed on Arsenic-Induced Hepatocellular Degeneration in Female Albino Rats

Chattopadhyay

Maiti

Maji

et al. 2010

Biol Trace Elem Res

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In an attempt to develop new herbal therapy, an aqueous extract of the seed of Moringa oleifera was used to screen the effect on arsenic-induced hepatic toxicity in female rat of Wistar strain. Subchronic exposure to sodium arsenite (0.4 ppm/100 g body weight/day via drinking water for a period of 24 days) significantly increased activities of hepatic and lipid function markers such as alanine transaminase, aspartate transaminase, cholesterol, triglycerides, LDL along with a decrease in total protein and HDL. A notable distortion of hepatocellular histoarchitecture was prominent with a concomitant increase in DNA fragmentation following arsenic exposure. A marked elevation of lipid peroxidation in hepatic tissue was also evident from the hepatic accumulation of malondialdehyde and conjugated dienes along with suppressed activities in the antioxidant enzymes such as superoxide dismutase and catalase. However, co-administration of aqueous seed extract of M. oleifera (500 mg/100 g body weight/day for a period of 24 days) was found to significantly prevent the arsenic-induced alteration of hepatic function markers and lipid profile. Moreover, the degeneration of histoarchitecture of liver found in arsenic-treated rats was protected along with partial but definite prevention against DNA fragmentation induction. Similarly, generation of reactive oxygen species and free radicals were found to be significantly less along with restored activities of antioxidant enzymes in M. oleifera co-administered group with comparison to arsenic alone treatment group. The present investigation offers strong evidence for the hepato-protective and antioxidative efficiencies of M. oleifera seed extract against oxidative stress induced by arsenic.

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Section: Discussionsupporting

confidence: 77%

Protective Role of Moringa oleifera (Sajina) Seed on Arsenic-Induced Hepatocellular Degeneration in Female Albino Rats

Chattopadhyay

Maiti

Maji

et al. 2010

Biol Trace Elem Res

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“…This has been evidenced as increases in lipoperoxidation levels and carbonylated proteins in different tissues; but also as deficits in either non-enzymatic antioxidants such as sulfhydryl groups, reduced glutathione, vitamins C and E, or in antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PD) (Bhadauria et al, 2008;Sinha et al, 2010;Srivastava & Shivanandappa, 2005).…”

Section: Resultsmentioning

confidence: 99%

Preclinical antitoxic properties ofSpirulina(Arthrospira)

Martínez-Galero

Pérez-Pasten

Pérez-Juárez

et al. 2015

Pharmaceutical Biology

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Context: Spirulina (Arthrospira) exerts a wide spectrum of pharmacological activities which are mainly attributed to its antioxidant effect. However, Spirulina has also been reported (both in preclinical and in clinical scenarios) to exhibit other bioactive effects, including an antitoxic potential.Objective: We performed a systematic review of the literature, conducted in TOXNET, PubMed/MEDLINE, and Science Direct-Scopus; all available years were included. Searching criteria included the effects of Spirulina on experimental poisonings from arsenic, cadmium, carbon tetrachloride, deltamethrin, fluoride, hexachlorocyclohexane, iron, lead, lindane, and mercury. Results: In all cases, it was established that the blue-green alga, and its isolated compounds, effectively counteracted these pollutants toxic effects on the exposed organisms. Some molecular mechanisms are proposed, although they have not been fully elucidated yet. Conclusion: Spirulina could be a useful coadjuvant agent within clinical practice for treatment of these or other pollutants poisonings.ARTICLE HISTORY

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“…Both black tea and green tea was efficient in reducing the As III induced DNA damage, lipid peroxidation and formation of protein carbonyl groups in Swiss albino mice. It was also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glutathione (GSH) in mice liver tissue (Sinha et al, 2010). The total oxy-radical scavenging capacity (TOSC) of catechins isolated from green tea was evaluated.…”

Section: Anti-oxidant Activitymentioning

confidence: 99%

Pharmacological profile of green tea and its polyphenols: a review

Bansal¹,

Syan²,

Moteriya³

et al. 2011

Med Chem Res

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Tea (Camellia sinensis, Theaceae) is the second most consumed beverages in the world, next to water in terms of worldwide popularity. The chemical components of green tea chiefly include polyphenols, caffeine, and amino acids. Green tea is rich in catechins, of which (-)-epigallocatechin-3-gallate is the most abundant. As described in literature, green tea and its polyphenols are beneficial in curing a wide variety of diseases like cancer, diabetes, cardiovascular disease, obesity, etc. It also has antimicrobial activity, protects from solar radiations, and possesses neuroprotective properties. The current review article focuses on pharmacological profile associated with Green tea and its polyphenols. We hope that this review will expose areas for further study and encourage research on important public health issue.

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Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice

Cited by 56 publications

References 24 publications

Protective Role of Moringa oleifera (Sajina) Seed on Arsenic-Induced Hepatocellular Degeneration in Female Albino Rats

Protective Role of Moringa oleifera (Sajina) Seed on Arsenic-Induced Hepatocellular Degeneration in Female Albino Rats

Preclinical antitoxic properties ofSpirulina(Arthrospira)

Pharmacological profile of green tea and its polyphenols: a review

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