Antioxidant potential of<i>Gaultheria fragrantissima</i>against adjuvant induced arthritis in Wistar rats

Shanmugarajan, T. S.; Maity, Niladri; Somasundaram, I.; Prithwish, N.; Soncharan, Patel; Ahamed, K.F.H. Nazeer

doi:10.1080/13880200902763014

Cited by 7 publications

(7 citation statements)

References 56 publications

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“…The inhibition of SOD activity in hepatitis rats may be attributed to inefficient scavenging of ROS, which might be implicated to oxidative inactivation of SOD. CAT is one of the heme proteins, which decomposes the hydrogen peroxide leads to protect the tissues from highly reactive hydroxyl radicals [34]. Our findings are supported by the previous studies, decline of SOD and CAT activity in DEN-induced hepatitis rats.…”

Section: Discussionsupporting

confidence: 81%

Hinokitiol-Ameliorated Diethylnitrosamine-Induced Hepatocarcinogenesis Through Antioxidant Mechanism in Rats: In Vitro and in Vivo Study

Fathima

Nainar

Somasundaram

et al. 2018

Asian J Pharm Clin Res

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Objective: Chemoprevention seems to be the best strategy for lowering the incidence of liver cancer. Therefore, this study has been initiated to investigate the hinokitiol (HIOL) supplementation which could prevent oxidative stress induced by hepatocarcinogen, diethylnitrosamine (DEN) in rats. Methods:The biochemical parameters such as tissue damaging enzymes, namely, alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and attack-free period and enzymatic antioxidants, namely, glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and histopathological changes were estimated.Results: DEN-treated rats shows increased ALT, ALP, and AST and decreased GSH, GST, CAT, GPx, GR, and SOD activities in liver tissues. The DENtreated group (200 mg/kg body weight single intraperitoneal injection) with phenobarbital 0.05% orally showed the severe histopathological lesions in liver tissue. Whereas, the groups received HIOL along with DEN shown a comparatively lesser damage. Here, the HIOL supplementation ameliorated the biochemical parameters as well as evoked enzymatic antioxidants in DEN-induced rats to the control values. Conclusion:The HIOL possesses potent antioxidant property, in this credence to that conception, the treatment with HIOL may prevent the development of chemical-induced hepatocarcinogenesis in rats by free radical scavenging mechanism.

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Section: Discussionsupporting

confidence: 81%

Hinokitiol-Ameliorated Diethylnitrosamine-Induced Hepatocarcinogenesis Through Antioxidant Mechanism in Rats: In Vitro and in Vivo Study

Fathima

Nainar

Somasundaram

et al. 2018

Asian J Pharm Clin Res

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“… 2012 ; Shanmugarajan et al. 2009 ). In this study, a significant elevation of two oxidation products, MDA and NO, as well as decreased the serum activity of SOD antioxidant were observed after CFA challenge.…”

Section: Discussionmentioning

confidence: 99%

The anti-arthritic activity of total glycosides from Pterocephalus hookeri, a traditional Tibetan herbal medicine

Shen

Zeng

Jia-chuan

et al. 2016

Pharmaceutical Biology

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Context:Pterocephalus hookeri (C. B. Clarke) Hock., a traditional Tibetan herbal medicine rich in glycosides, has been used to treat several diseases including rheumatoid arthritis.Objective: To evaluate the anti-arthritic activity of total glycosides from P. hookeri, and its possible mechanisms of action.Materials and methods: Anti-arthritic activity of total glycosides from P. hookeri (oral administration for 30 days at 14–56 mg/kg) was evaluated using paw swelling, arthritis scores and histopathological measurement in adjuvant-induced arthritis (AA) Sprague-Dawley rats. The NF-κB p65 expression in synovial tissues, and serum superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) levels was measured in AA rats, respectively. Further assessment of anti-inflammatory and analgesic activities of these glycosides were carried out using inflammation and hyperalgesia models induced by xylene, carrageenan, agar and acetic acid, respectively.Results: Total glycosides (56 mg/kg) decreased the paw swelling (38.0%, p < 0.01), arthritis scores (25.3%, p < 0.01) and synovial inflammation in AA rats. The glycosides significantly (p < 0.05–0.01) attenuated the inflammation induced by xylene, carrageenan, acetic acid and agar, increased the pain threshold in acetic acid-induced writhing in mice and mechanical stimuli-induced hyperalgia in AA rats. The glycosides (14, 28, 56 mg/kg) also suppressed the NF-κB p65 expression (33.1–78.2%, p < 0.05–0.01), reduced MDA (21.3–35.9%, p < 0.01) and NO (20.3–32.4%, p < 0.05–0.01) levels, respectively, enhanced the SOD activity (7.8%, p < 0.05) at 56 mg/kg in AA rats.Discussion and conclusion: Our findings confirmed the anti-arthritic property of the total glycosides from P. hookeri, which may be attributed to its inhibition on NF-κB signalling and oxidative stress.

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“…Gaultheria fragrantissima Wall. Ericaceae Leaves Fever, headaches, inflammatory joint disorders, back pain, and used as antifebrile and diuretic [11] Nematicidal [63], antioxidant [70], antifungal [71], and insecticidal properties [68,72] 9. Hydnocarpus kurzii (King) Warb.…”

Section: Stemona Burkilliimentioning

confidence: 99%

“…[61], salicylic acid [61][62], p-hydroxybenzoic acid, o-pyrocatechuic acid, gentisic acid, protocatechuic acid, vanillic acid, p-coumaric acid, caffeic acid, ferulic acid [62], ethyl salicylate [63], 4-hydroxy-4-methyl-2-pentanone [64], methyl sailicylate [63][64][65][66][67][68], α-pinene, β-pinene, Δ 3 -carene, longifolene, and caryophyllene oxide [69]. Pharmacological studies have highlighted the nematicidal [63], antioxidant [70], antifungal [71], and insecticidal properties [68,72] of G. fragrantissima.…”

Section: Gaultheria Fragrantissimamentioning

confidence: 99%

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A Review of Common Medicinal Plants in Chin State, Myanmar

Thu¹,

Aye

Aung

et al. 2018

Natural Product Communications

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Promising sources of novel bioactive compounds include plants growing in several third-world countries where the local flora is still largely uninvestigated. A paradigmatic example is represented by medicinal plants growing in Myanmar, especially in Chin State, in northwestern Myanmar. This is one of the least developed areas of the country where the people still use natural remedies derived from a rich biodiversity. This review mainly covers the investigations done on phytochemical constituents and biological activities of 20 medicinal plants, namely Alangium chinense,

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Antioxidant potential ofGaultheria fragrantissimaagainst adjuvant induced arthritis in Wistar rats

Cited by 7 publications

References 56 publications

Hinokitiol-Ameliorated Diethylnitrosamine-Induced Hepatocarcinogenesis Through Antioxidant Mechanism in Rats: In Vitro and in Vivo Study

Hinokitiol-Ameliorated Diethylnitrosamine-Induced Hepatocarcinogenesis Through Antioxidant Mechanism in Rats: In Vitro and in Vivo Study

The anti-arthritic activity of total glycosides from Pterocephalus hookeri, a traditional Tibetan herbal medicine

A Review of Common Medicinal Plants in Chin State, Myanmar

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