Antioxidant potential ethanolic extract of Glycine max (l.) Merr. Var. Detam and daidzein

Prahastuti, Sijani; Hidayat, Moch. Amrun; Hasianna, Stella Tinia; Widowati, Wahyu; Amalia, Annisa; Yusepany, D T; Rizal, R; Kusuma, Hanna Sari Widya

doi:10.1088/1742-6596/1374/1/012020

Cited by 13 publications

(32 citation statements)

References 31 publications

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“…About 10 mg of EEGU was placed on spotting plates and added with 1% FeCl 3 . The phenols availability was shown by forming of black, red, blue, purple, or green color (Bera et al, 2015;Adnyana et al, 2016;Widowati et al, 2018;Prahastuti et al, 2019b).…”

Section: Phenols Identificationmentioning

confidence: 99%

“…One mL of absolute H 2 SO 4 was added to the mixture. Steroids were detected when blue or green color is formed, while triterpenoids were shown by orange or red sediment formation (Bera et al, 2015;Adnyana et al, 2016;Widowati et al, 2018;Prahastuti et al, 2019b).…”

Section: Steroids/triterpenoids Identificationmentioning

confidence: 99%

“…Total phenolic content was asserted as gallic acid equivalence (GAE) in μg/mg sample. This test was done triplicate (Nurhayati et al, 2018;Rusmana et al, 2017;Widowati et al, 2015;Prahastuti et al, 2019b).…”

Section: Phenolic Content Assaymentioning

confidence: 99%

“…Flavonoid content was conducted using the altered previous method (Kalita et al, 2013;Prahastuti et al, 2019b). Briefly, standard solution in 7 concentration level of epicatechin and EEGU at 1000 μg/mL and 2000 μg/mL as much as 15 µL was used in this method.…”

Section: Flavonoid Content Assaymentioning

confidence: 99%

“…The flavonoid content was presented as quercetin equivalence (QE) in μg/mg. The experiment was done triplicate (Prahastuti et al, 2019b).…”

Section: Flavonoid Content Assaymentioning

confidence: 99%

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The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants

Prahastuti¹,

Hidayat²,

Hasiana³

et al. 2020

Pharmaciana

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Guazuma ulmifolia, or commonly known as the bastard cedar, has many pharmaceutical activities. Therefore, it is claimed as a source of various plant-based medicines. This research was purposed to identify the antioxidant activities of the ethanolic extract of G. ulmifolia (EEGU) by phytochemical screening assay, total flavonoid and total phenolic testing, and comparative analysis between the antioxidant activities of EEGU and epicatechin. The qualitative phytochemical screening assay of EEGU detected the availability of phenols, flavonoids, alkaloids, tannins, and terpenoids, but not saponins and triterpenoids. Meanwhile, the total phenolic content was 32.24 µg GAE/mg extract, and the total flavonoid content was 6.48 µg QE/mg extract. The role of antioxidants examined by FRAP, DPPH, H 2 O 2 , and ABTS assays. These assays are proved that the IC 50 values of EEGU are higher than epicatechin. For DPPH scavenging, H 2 O 2 scavenging, and ABTS reduction activities, EEGU resulted IC 50 45.70 μg/mL, 162.93 μg/mL, and 35.96 μg/mL, while epicatechin only yielded IC 50 0.56 μg/mL, 57.91 μg/mL, and 16.74 μg/mL respectively. Otherwise, the highest reduction in FRAP activities were shown at 50 μg/mL concentration of epicatechin and EEGU were 236.33 and 202.71 µM Fe (II)/µg respectively. Based on these results, EEGU is concluded as an active natural product because it exhibited antioxidant activities.

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Section: Phenols Identificationmentioning

confidence: 99%

Section: Steroids/triterpenoids Identificationmentioning

confidence: 99%

Section: Phenolic Content Assaymentioning

confidence: 99%

Section: Flavonoid Content Assaymentioning

confidence: 99%

“…The flavonoid content was presented as quercetin equivalence (QE) in μg/mg. The experiment was done triplicate (Prahastuti et al, 2019b).…”

Section: Flavonoid Content Assaymentioning

confidence: 99%

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The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants

Prahastuti¹,

Hidayat²,

Hasiana³

et al. 2020

Pharmaciana

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Combination of natural antivirals and potent immune invigorators: A natural remedy to combat COVID‐19

Shah

Rasul

Yousaf

et al. 2021

Phytotherapy Research

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The flare‐up in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that emerged in December 2019 in Wuhan, China, and spread expeditiously worldwide has become a health challenge globally. The rapid transmission, absence of anti‐SARS‐CoV‐2 drugs, and inexistence of vaccine are further exacerbating the situation. Several drugs, including chloroquine, remdesivir, and favipiravir, are presently undergoing clinical investigation to further scrutinize their effectiveness and validity in the management of COVID‐19. Natural products (NPs) in general, and plants constituents specifically, are unique sources for various effective and novel drugs. Immunostimulants, including vitamins, iron, zinc, chrysin, caffeic acid, and gallic acid, act as potent weapons against COVID‐19 by reinvigorating the defensive mechanisms of the immune system. Immunity boosters prevent COVID‐19 by stimulating the proliferation of T‐cells, B‐cells, and neutrophils, neutralizing the free radicals, inhibiting the immunosuppressive agents, and promoting cytokine production. Presently, antiviral therapy includes several lead compounds, such as baicalin, glycyrrhizin, theaflavin, and herbacetin, all of which seem to act against SARS‐CoV‐2 via particular targets, such as blocking virus entry, attachment to host cell receptor, inhibiting viral replication, and assembly and release.

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