Antioxidant Potential, DNA Damage, Inflammation, Glycemic Control and Lipid Metabolism Alteration: A Mediation Analysis of Islamic Sunnah Intermittent Fasting on Cognitive Function among Older Adults with Mild Cognitive Impairment

Ooi, Theng Choon; Meramat, Asheila; Rajab, Nor Fadilah; Shahar, Suzana; Sharif, Razinah

doi:10.1007/s12603-022-1757-0

Cited by 5 publications

(9 citation statements)

References 46 publications

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“… Ooi et al (2022) reported an association between IFA and improved cognitive function in older adults with mild cognitive impairment. When comparing the regular-IFA and n-IFA groups, the analysis shows That the practice of intermittent fasting was correlated with a reduced Malondialdehyde (MDA) level [b = 49.19, t(87) = 10.29, p= <0.001], higher Superoxide Dismutase (SOD) activity [b = -38.91, t(87) = -6.84, p=<0.001], lower percentage of DNA in tail [b = 8.19, t(87) = 11.36, p=<0.001], and lower CRP level [b = 1.39, t(87) = 13.01, p=< 0.001).…”

Section: Resultsmentioning

confidence: 99%

“… More individuals in the regularly practicing IF group reverted to successful aging with no cognitive impairment and diseases compared to irregular and non-practicing IF groups. Ooi et al (2022) , Malaysia N = 99, mean age = 68.66 (S.D = 5.08), 53 men and 46 women Cohort study Intermittent Fasting Grouping: regularly practicing IF, irregularly practicing IF, or not practicing IF The Mini Mental Examination State, Montreal Cognitive Assessment, Rey Auditory Verbal Learning Test, Digit Span Test, and Digit Symbol were administered at baseline and again 36 months later. IF practice was associated with improved cognitive function.…”

Section: Resultsmentioning

confidence: 99%

“…When comparing the regular-IFA and n-IFA groups, the analysis shows That the practice of intermittent fasting was correlated with a reduced Malondialdehyde (MDA) level [b = 49.19, t(87) = 10.29, p= <0.001], higher Superoxide Dismutase (SOD) activity [b = -38.91, t(87) = -6.84, p=<0.001], lower percentage of DNA in tail [b = 8.19, t(87) = 11.36, p=<0.001], and lower CRP level [b = 1.39, t(87) = 13.01, p=< 0.001). Furthermore, the mediating influence of reduced DNA damage, lower CRP levels, and higher levels of high-density lipoprotein (HDL) on cognitive function suggests potential pathways through which intermittent fasting may exert its cognitive benefits ( Ooi et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

Sharifi,

Rostami,

Babaei Khorzoughi

et al. 2024

Preventive Medicine Reports

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

Sharifi,

Rostami,

Babaei Khorzoughi

et al. 2024

Preventive Medicine Reports

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“…Synchronization of peripheral clocks is essential for coordinated physiology. Disruptions in circadian rhythms can lead to disturbances in metabolism, resulting in various adverse consequences, from irritability and fatigue to chronic diseases like obesity, type 2 diabetes mellitus, cardiovascular diseases, and inflammation [10,12,43,[51][52][53][54][55][56][57].…”

Section: The Circadian Regulation Of Glucose Metabolismmentioning

confidence: 99%

Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health

Drăgoi,

Nicolae,

Ungurianu

et al. 2024

Cells

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A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances and endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, and in contemporary society, there is a prevalent occurrence of misalignments between the circadian system and environmental cues, a phenomenon frequently associated with adverse health consequences. The onset of most prevalent current chronic diseases is intimately connected with alterations in human lifestyle practices under various facets, including the following: reduced physical activity, the exposure to artificial light, also acknowledged as light pollution, sedentary behavior coupled with consuming energy-dense nutriments, irregular eating frameworks, disruptions in sleep patterns (inadequate quality and duration), engagement in shift work, and the phenomenon known as social jetlag. The rapid evolution of contemporary life and domestic routines has significantly outpaced the rate of genetic adaptation. Consequently, the underlying circadian rhythms are exposed to multiple shifts, thereby elevating the susceptibility to disease predisposition. This comprehensive review endeavors to synthesize existing empirical evidence that substantiates the conceptual integration of the circadian clock, biochemical molecular homeostasis, oxidative stress, and the stimuli imparted by physical exercise, sleep, and nutrition.

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“…In older adults with mild cognitive impairment, a 36-month IF regimen has been shown to reduce the level of oxidative stress by increasing superoxide dismutase activity. [269,270] Both TRF and IF can reduce DNA damage, which is related to the upregulation of key DNA repair proteins such as centrosomal protein 164 and apurinic/apyrimidinic endonuclease-1. [271,272] In addition, DNA damage alters telomeres, resulting in telomere shortening, cellular senescence, and death.…”

Section: Agingmentioning

confidence: 99%

Fasting: From Physiology to Pathology

Tang

Huang

et al. 2023

Advanced Science

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Overnutrition is a risk factor for various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a simple but attractive strategy for the treatment of these increasing public health threats. Fasting as a dietary intervention for combating overnutrition has been extensively studied. Fasting has been practiced for millennia, but only recently have its roles in the molecular clock, gut microbiome, and tissue homeostasis and function emerged. Fasting can slow aging in most species and protect against various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. These centuried and unfading adventures and explorations suggest that fasting has the potential to delay aging and help prevent and treat diseases while minimizing side effects caused by chronic dietary interventions. In this review, recent animal and human studies concerning the role and underlying mechanism of fasting in physiology and pathology are summarized, the therapeutic potential of fasting is highlighted, and the combination of pharmacological intervention and fasting is discussed as a new treatment regimen for human diseases.

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Antioxidant Potential, DNA Damage, Inflammation, Glycemic Control and Lipid Metabolism Alteration: A Mediation Analysis of Islamic Sunnah Intermittent Fasting on Cognitive Function among Older Adults with Mild Cognitive Impairment

Cited by 5 publications

References 46 publications

Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health

Fasting: From Physiology to Pathology

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