Antioxidant potential and total phenolic content of methanolic bark extract of Madhuca indica (koenig) Gmelin

Chaudhary, Anu; Bhandari, Anil; Pandurangan, A. G.

doi:10.4103/0257-7941.103197

Cited by 11 publications

(8 citation statements)

References 18 publications

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“…After 4 h, native flavonoid content starts dissipating from the target site. The short-stay period of native phytoextract has also been noticed earlier [44,45]. The present study demonstrates an improved stay period of gold nanoparticles loaded with plant flavonoids, finally leading to improved bio-availability.…”

Section: Enhancement Of Stay Periodsupporting

confidence: 81%

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Anti-Melanoma Bio-Efficacy of the Plant Madhuca Longifolia and Its Enhancement Using Bioactive Principle Loaded Gold Nanoparticle

Yadav¹,

Sharma²,

Ganesh³

et al. 2020

Asian J Pharm Clin Res

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Objective: Unexplored in-vivo anti-melanoma bio-efficacy of the plant Madhuca longifolia (bark) has been carried out against C57BL/6 mice. Methods: Optimized experimental conditions of phytofabrication of gold nanoparticles were as follows: flavonoid content (1 ml, 0.5 mg/ml), sodium tetrachloroaurate dihydrate solution (2 ml, 1 mM), and sonication (15 min, 20 KHz) at pH 4. The optical properties; ultraviolet-visible spectrophotometer (UV-Vis), particles size and zeta potential (Zetasizer), miller indices; X-ray diffraction (XRD), morphology; field emission-scanning electron microscope (FE-SEM), particle size; high resolution-transmission electron microscopy (HR-TEM), surface roughness; atomic force microscopy (AFM) and elemental composition; and energy dispersive X-rays (EDX) of flavonoid loaded gold nanoparticles. In-vivo anti-melanoma bio-efficacy has been carried out against C57BL mice. Radioisotopic, hematological, and histopathological studies were carried out using standard procedures. Results: Redox potential of the total flavonoid extracted from the bark of the plant (Madhuca longifolia) has been used for the fabrication of flavonoid loaded gold nanoparticles (F@AuNp) and confirmed for the first time their significant anti-melanoma bio-efficacy. The finding is supported by hematological and histopathological studies carried out in the organs (liver, kidney, and intestine) of C57BL mice. The significant enhancement in phytofabricated F@AuNp compared to native bark extract of the plant has been assigned to enhanced stay period and nanosizing, biocompatibility, nontoxic nature, and enhanced beneficial payload to the cancerous cells. Conclusion: Such phytofabricated gold nanoparticles possess an admirable prospect for the expansion of herbal nanomedicine for anti-melanoma bio-efficacy.

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Section: Enhancement Of Stay Periodsupporting

confidence: 81%

“…They have high medicinal potential behaving as strong antioxidants. Antioxidants, as immunity boosters, have also been proved to strengthen the anticancer activity [42][43][44]. Relevant literature indicates the presence of flavonoid in a substantial amount in the plant Madhuca longifolia.…”

Section: Resultsmentioning

confidence: 99%

Anti-Melanoma Bio-Efficacy of the Plant Madhuca Longifolia and Its Enhancement Using Bioactive Principle Loaded Gold Nanoparticle

Yadav¹,

Sharma²,

Ganesh³

et al. 2020

Asian J Pharm Clin Res

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“…Meanwhile, nhexane extract only gives an inhibition of 1 2 3 29.63%. Extracts are categorized potent containing antioxidant compounds when its have percent inhibition > 50% at a concentration of 1000 μg/mL (Chaudhary et al, 2012). Based on this data it is stated that the extract of ethyl acetate and ethanol extract from stems of supit (Tetracera indica) potentially contain antioxidant compounds.…”

Section: Resultsmentioning

confidence: 99%

Flavon Compound from The Ethyl Acetate Extract of The Stem of Supit (Tetracera indica Merr.)

Muharni¹,

Elfita²,

Adillah

et al. 2018

Molekul

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Tetracera indica Merr. in Musi Banyuasin, is one of the traditional medicine used by the community for the treatment of kidney stone disease and gout, but this claim is not recorded in the treatment of kidney stones and gout in Indonesia. In this study, isolation of antioxidant compound from ethyl acetate extracts of supit (Tetracera indica) was done. The isolation was carried out through step gradient polarity extraction, and separated and purified by chromatography technique. The determination of the structure of the isolated compound was performed by spectroscopy method including UV, IR, and NMR 1D and 2D, and antoxidant activity was determined by DPPH method. An active antioxidant compound was isolated from ethyl acetate extract in form of yellow solid (15 mg). Based on spectroscopic analysis the isolated compound was 5,8-dihydroxy-7-methoxyflavone. The compound showed strong antioxidant activity (IC50 8.25 μg/mL) higher than standard ascorbic acid (IC50 11.3 μg/mL). This data concluded that efficacy of supit (Tetracera indica) for the treatment related to antioxidant activity (uric acid) is proven by the identification of one antioxidant compound of this plant.

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“…To this mixture, 100 μl of PMS solution (60 μM PMS in 100 mM phosphate buffer, pH 7.4) was added. The reaction mixture was then incubated at 25°C for 5 min, and the absorbance was measured at 560 nm against the blank sample using a UV-visible spectrophotometer [11]. Lower the absorbance of the test mixtures indicated higher superoxide radical scavenging activity.…”

Section: Superoxide Radical Scavenging Activitymentioning

confidence: 99%

Investigation of Pharmacognostical, Phytochemical, and Pharmacological Activity of Aerial Roots of Ficus Benghalensis Linn

Mazumder¹,

Maji²,

Bala³

2018

Asian J Pharm Clin Res

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Objective: Ficus benghalensis Linn. (Moraceae family) is commonly known as banyan tree in English, which is used traditionally in India. The literature survey showed that the aerial roots of this plant are yet to be explored. Our main interest is to evaluate its pharmacognostic and phytochemical character by the standard monograph and to explore its in vitro antioxidant and in vivo analgesic activity study with ethyl acetate extract.Methods: Pharmacognostic evaluation and phytochemical screening have been done using standard monograph. An in vitro antioxidant activity using ethyl acetate extract has been done using four different methods. In vivo analgesic activity of the ethyl acetate extract has been evaluated by acetic acid-induced writhing test in mice and tail flick method.Results: Aerial roots of F. benghalensis have been found the rich source of steroidal glycosides, cardiac glycosides, flavonoids, tri-terpenoids, and phenols. The presence of phellem, phellogen, xylem, and phloem has been found after microscopic investigation. All the pharmacognostic parameters proved its purity. Results showed the absence of heavy metals. The ethyl acetate extract has shown potent antioxidant activity at 100 μg/ml concentration and higher analgesic activity at the concentration of 400 mg/kg than 200 mg/kg.Conclusion: Pharmacognostic characteristics and phytochemical properties revealed in this study could be used for the pharmacopoeial standard. Ethyl acetate extract showed potent antioxidant and analgesic activity.

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Antioxidant potential and total phenolic content of methanolic bark extract of Madhuca indica (koenig) Gmelin

Cited by 11 publications

References 18 publications

Anti-Melanoma Bio-Efficacy of the Plant Madhuca Longifolia and Its Enhancement Using Bioactive Principle Loaded Gold Nanoparticle

Anti-Melanoma Bio-Efficacy of the Plant Madhuca Longifolia and Its Enhancement Using Bioactive Principle Loaded Gold Nanoparticle

Flavon Compound from The Ethyl Acetate Extract of The Stem of Supit (Tetracera indica Merr.)

Investigation of Pharmacognostical, Phytochemical, and Pharmacological Activity of Aerial Roots of Ficus Benghalensis Linn

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