Antioxidant Polymers as Biomaterial

Lith, Robert van

doi:10.1016/b978-0-12-803269-5.00010-3

Cited by 37 publications

(25 citation statements)

References 135 publications

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“…In this context, the design of biocompatible materials, able to control oxidant species in situ and lessen all the derived pathological consequences, represents a promising research field. The synthesis of antioxidant polymer-based materials can follow different strategies, varying from the simple encapsulation of antioxidant compounds to the incorporation of antioxidant molecules into the backbone structure through covalent bonds, to form intrinsically antioxidant polymers [5].…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Entrapped in Hybrid Materials with High PEG Content: A Strategy to Obtain Antioxidant Functionalized Biomaterials?

Catauro

Barrino

Poggetto³

et al. 2019

Materials

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The formation of pro-oxidant species after implantation of biomaterials could be responsible for the failure of the implant itself, because of oxidative stress-induced damage. In this work, the SiO2/polyethylene glycol (PEG)/chlorogenic acid (CGA) hybrids synthesized by the sol–gel method with 50 wt% of the polymer and different amounts of CGA (5, 10, 15 and 20 wt%) were studied. The hybrids soaked in simulated body fluid (SBF) showed the formation of hydroxyapatite layers on their surface, suggesting that the hybrids are bioactive. Their radical scavenging capacity towards DPPH· and ABTS·+ (2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), evaluated at three different doses (0.5, 1 and 2 mg), showed probe- and dose-dependent behavior. In addition, the antioxidant properties of CGA were not affected by the presence of high amounts of the polymer. The in vitro biocompatibility in three cell lines (NIH 3T3, HaCaT and SH-SY5Y) was assessed by using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Apart from SH-SY5Y, the cell viability—expressed as mitochondrial redox activity percentage of cells directly exposed to powders—and morphology was not affected, suggesting that the hybrids have the ability to interfere and act selectively against tumor cells. The antibacterial properties of the different materials against Escherichia coli and Enterococcus faecalis were affected by different amounts of the natural antioxidant component.

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Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Entrapped in Hybrid Materials with High PEG Content: A Strategy to Obtain Antioxidant Functionalized Biomaterials?

Catauro

Barrino

Poggetto³

et al. 2019

Materials

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“…Vitamin A is a class of fat-soluble chemical compounds, known as retinoids, that includes retinol, retinal, and retinoic acid [92,93,94]. Retinol, the most active form, is an important chain-breaking antioxidant, involved in scavenging superoxide and hydroxyl radicals [94].…”

Section: Antioxidants For Neuroprotectionmentioning

confidence: 99%

Antioxidant Therapies for Neuroprotection—A Review

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection.

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“…Gallic acid exists in plant material in the form of free acids, esters, catechin derivatives and hydrolysable tannins. This ubiquitous chemical substance is one of the most biologically-active phenolic compounds of plants [26]. Thus, a 0.1M FeSO4 .…”

Section: -3-gallic Acid For the Synthesis Of Nzvi Nanoparticlesmentioning

confidence: 99%

Synthesis of Aqueous Suspensions of Zero-Valent Iron Nanoparticles (nZVI) from Plant Extracts: Experimental Study and Numerical Modeling

Karavasilis

Tsakiroglou

2019

Emerg Sci J

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Plant extracts were produced from Camellia sinesis (Green Tea) and Punica granatum (pomegranate), and the total concentration of polyphenols was measured in terms of equivalent concentration of Gallic acid by using the Folin-Ciocalteu method. Zero Valent Iron nanoparticles (nZVIs) were synthesized in a semi-batch reactor by mixing a pre-specified volume of plant extract or Gallic Acid solution with an aqueous solution of iron sulfate heptahydrate (FeSO4·7H2O). To monitor the kinetics of nZVI synthesis, the transient responses of solution pH and redox potential (Eh) were recorded with two probes adequately connected with a data acquisition card. The nanoparticles were characterized by a variety of techniques: Dynamic Light Scattering (DLS), ζ-potential, Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, Transmission Electron Microscopy (TEM). A kinetic parametric model, based on two parallel single electron transfer (SET) and hydrogen atom transfer (HAT) reactions, was suggested to quantify the dynamics of ferrous ions reduction to zero valence, and its parameters were estimated for each experimental system by matching the transient response of pH. The temporal changes of redox potential during nZVI synthesis were indicative of the reaction progress and agreed with the numerical predictions in semi-quantitative basis. The numerical model enabled us to track the temporal variation of the concentration of iron and polyphenol species, and calculate the yield of ZVI synthesis. The reactivity of nZVIs was assessed by measuring their capacity to reduce hexavalent chromium Cr (VI) in aqueous solutions prepared from potassium dichromate (K2Cr2O7).

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Antioxidant Polymers as Biomaterial

Cited by 37 publications

References 135 publications

Chlorogenic Acid Entrapped in Hybrid Materials with High PEG Content: A Strategy to Obtain Antioxidant Functionalized Biomaterials?

Chlorogenic Acid Entrapped in Hybrid Materials with High PEG Content: A Strategy to Obtain Antioxidant Functionalized Biomaterials?

Antioxidant Therapies for Neuroprotection—A Review

Synthesis of Aqueous Suspensions of Zero-Valent Iron Nanoparticles (nZVI) from Plant Extracts: Experimental Study and Numerical Modeling

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