Antioxidant, phytochemical and physicochemical properties of sesame seed (Sesamum indicum L)

Dravie, Emmanuel Elikem; Kortei, Nii Korley; Essuman, Edward Ken; Tettey, Clement Okraku; Boakye, Adjoa Agyemang; Hunkpe, Gaston

doi:10.1016/j.sciaf.2020.e00349

Cited by 39 publications

(38 citation statements)

References 13 publications

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“…These selected spices are already known to have several promising activities, mainly antioxidant, anti-inflammatory, immunomodulatory, and anti-viral [ 38 , 57 ]. Primarily, F. asafoetida can function as an anti-viral agent against influenza A (H1N1) and herpes virus type 1 (HSV-1) [ 42 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

Natesh

Mondal

Penta

et al. 2021

Computers in Biology and Medicine

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Background Coronavirus disease-(COVID-19) is an infectious pandemic caused by SARS-CoV-2. SARS-CoV-2 main protease (M pro ) and spike protein are crucial for viral replication and transmission. Spike protein recognizes the human ACE2 receptor and transmits SARS-CoV-2 into the human body. Thus, M pro , spike protein, and ACE2 receptor act as appropriate targets for the development of therapeutics against SARS-CoV-2. Spices are traditionally known to have anti-viral and immune-boosting activities. Therefore, we investigated the possible use of selected spice bioactives against the potential targets of SARS-CoV-2 using computational analysis. Methods Molecular docking analysis was performed to analyze the binding efficiency of spice bioactives against SARS-CoV-2 target proteins along with the standard drugs. Drug-likeness properties of selected spice bioactives were investigated using Lipinski's rule of five and the SWISSADME database. Pharmacological properties such as ADME/T, biological functions, and toxicity were analyzed using ADMETlab, PASS-prediction, and ProTox-II servers, respectively. Results Out of forty-six spice bioactives screened, six bioactives have shown relatively better binding energies than the standard drugs and have a higher affinity with at least more than two targets of SARS-CoV-2. The selected bioactives were analyzed for their binding similarities with the standard drug, remdesivir, towards the targets of SARS-CoV-2. Selected spice bioactives have shown potential drug-likeness properties, with higher GI absorption rate, lower toxicity with pleiotropic biological roles. Conclusions Spice bioactives have the potential to bind with the specific targets involved in SARS-CoV-2 infection and transmission. Therefore, spice-based nutraceuticals can be developed for the prevention and treatment of COVID-19.

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Section: Resultsmentioning

confidence: 99%

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

Natesh

Mondal

Penta

et al. 2021

Computers in Biology and Medicine

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“…It is also a significant source of dietary fiber and micronutrients such as minerals, including calcium, phosphate, iron, potassium, vitamins such as E, thiamine, and niacin, lignans tocopherols, and phytosterols (Elleuch et al, 2011;Yao et al, 2021). Sesame seeds have antioxidant, anti-inflammatory, anti-fungal, anti-viral, and natural antibacterial effects (Dravie et al, 2020). Sesame seeds are consumed in different forms in the world (Namiki, 2007).…”

Section: Extract and Cleanup Of Afmentioning

confidence: 99%

The prevalence and risk assessment of aflatoxin in sesame based products

2021

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The contamination of aflatoxins (AFs) in 120 samples of sesame seeds, tahini, and tahini halva collected from Iran’s market were evaluated. The exposed risk due to ingestion of aflatoxin B1 (AFB1) via their consumption was estimated with the aid of the Monte Carlo simulation (MCS). The highest prevalence of AF (55%) was associated with sesame seed samples, followed by tahini (45%) and tahini halva (32.5%). The AFB1 concentration in sesame seeds, tahini, and tahini halva was in the ranges of 0.21–12.35, 0.23–5.81, and 0.27–3.56 ?g/kg, respectively. The concentration of the total aflatoxin (TAF) in 7 (17.5%), 8 (20%), and 2 (5%) samples of sesame seeds, tahini, and tahini halva, respectively, was below the limit of European regulations (4 µg/kg), while the levels of AFB1 in 10 (25%), 7 (17.5%), and 6 (15%) samples of sesame seeds, tahini, and tahini halva, respectively, were higher than the European regulations (2 µg/kg). As the percentile 50 and 95 of margin of exposure (MOE) with AFB1 for sesame seed, tahini, and tahini halva was more than 10,000, it could conclude the intake of aflatoxin through the consumption of mentioned products did pose a not remarkable cancer risk for adults.

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“…The antioxidant, phytochemical and physicochemical properties were determined. Sesame seeds possess significant antioxidant activity [7].…”

Section: Antioxidant Activity Of Sesame Seedsmentioning

confidence: 99%

Edible Seeds Medicinal Value, Therapeutic Applications and Functional Properties-a Review

Chandrasekar¹,

Sivagami²

2021

Int J Pharm Pharm Sci

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India has a rich source of tropical fruits containing edible seeds such as chia, hemp, sesame, pumkin, sunflower, mustard, nigella, guava, papaya, mangosteen, honeydew, pomegranate, fennel, fenugreek, cumin, sweet orange, cucumber, jackfruit, mango, melons, avocado and many more. These products such as the seed kernel, which constitutes about 10–35% of the weight, offer high nutritional value and therapeutic applications. This article explores the nutritional, medicinal, therapeutic applications, functional properties and bioactive constituents of the seeds of some fruits, which are analyzed for their functions and applications as sources of food value and bioactive phytochemical constituents. The seeds contain essential bioactive components such as alkaloids, carotenoids, flavonoids, glycosides, saponins, terpenoids, tannins, steroids and polyphenolic compounds and that exhibit excellent anti-inflammatory, antioxidant properties, anticancer, anti-diabetic, anti-hyperlipidemic, anti-obesity, neurological disorders, cardiovascular, skin diseases and chronic diseases. They have remarkable physicochemical properties and a high content of carbohydrates, fats, proteins, vitamins, and minerals. However extensive research activities can be carried out to determine the efficacy of the nutritional and bioactive components in different seed types, the bioavailability and potency. Extensive research with the seed parts can be investigated to identify the medicinal and functional potentials of these fruit seeds. This review gives an overview on the therapeutic applications and functional properties of seeds present in fruits, vegetables and medicinal plants. The medicinal and nutritional value, phytochemical composition, bioactive phytoconstituents, therapeutic activity, therapeutic applications and uses, proximate analysis, functional properties, analytical methods, spectroscopic methods and human clinical trials of some edible seeds are discussed in this review.

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Antioxidant, phytochemical and physicochemical properties of sesame seed (Sesamum indicum L)

Cited by 39 publications

References 13 publications

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

The prevalence and risk assessment of aflatoxin in sesame based products

Edible Seeds Medicinal Value, Therapeutic Applications and Functional Properties-a Review

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