Antioxidant-phenolic content correlation of phenolics rich fractions from Dillenia suffruticosa wood bark

Abstract

Dillenia suffruticosa is one of the tropical medicinal plants that has been used traditionally for treating several tropical diseases. However, phytochemical and pharmacological investigations of D. suffruticosa wood bark have not been well-investigated. This research aimed to investigate the correlation between antioxidant properties and total phenolic content of phenolics rich extract and fractions from D. suffruticosa wood bark. The phytochemical investigation revealed the existence of phenolics and alkaloids in methanolic crude wood bark extract and all fractions. Meanwhile, the presence of flavonoids was shown in chloroform and methanol fractions. The highest total phenolic content was demonstrated by methanol fraction with 254.34 ± 16.86 mg GAE/g extract. Meanwhile, the highest total flavonoid content was interestingly displayed in chloroform fraction with 15.33 ± 0.26 mg RE/g extract. The crude extract and methanol fraction had a profound antioxidant activity with IC 50 values of less than 15.63 ppm and 8.83 ppm, respectively. A strong correlation was shown between the antioxidant activity and total phenolic contents through correlation analysis. Thus, the D. suffruticosa wood bark could be considered a potential natural source of antioxidants.

Phytochemical Screening of Ethanol Extracts from Three Variants of Kratom Leaves (Mitragyna speciosa Korth.)

“…Based on qualitative testing, the three variants of kratom leaves show a change in concentrated green color, which is blackish green quickly after adding FeCl3 solution (Figure 5), so it is suspected that the third variant of kratom leaves has good antioxidant activity (Bayani, 2016). Muharini & Lestari (2021) found that there is a correlation between the content of phenolic compounds and the antioxidant activity of a plant. Setyawati (2020) showed that kratom leaves have antioxidant activity.…”

Sitotoksisitas dan Selektivitas Fraksi Kayu Batang Simpur Air (Dillenia suffruticosa (Griff.) Martelli) Terhadap Sel Kanker Payudara

“…Penelitian terhadap bagian kayu batang simpur air berasal dari Kalimantan Barat, Indonesia yang menunjukkan adanya kandungan senyawa yaitu alkaloid, flavonoid, fenolik, saponin, steroid dan terpenoid. Analisis korelasi diketahui bahwa aktivitas antioksidan yang kuat dari ekstrak kayu batang simpur air disebabkan oleh kandungan fenoliknya (Muharini et al, 2021). Banyak penelitian telah mengungkapkan bahwa agen antioksidan ditemukan untuk menampilkan sifat farmakologis lain, seperti antiinflamasi (Chen et al, 2019), sitotoksisitas (Gacche & Jadhav, 2012) atau antikanker (Grigalius & Petrikaite, 2017).…”

“…Penelitian terdahulu melaporkan bahwa kulit batang simpur air mengandung metabolit sekunder alkaloid, flavonoid, fenolik, saponin, steroid, dan terpenoid (Muharini et al, 2021). Senyawa yang diyakini berkontribusi terhadap sifat sitotoksik yang tinggi dari fraksi n-heksana merupakan senyawa yang bersifat non-polar, salah satunya adalah senyawa sterol yang merupakan subkelompok steroid.…”