Antioxidant peptides from plants: a review

César, Artúr; Lopes, Francisco E.S.; Azevedo, Francisca Fernanda Nunes; Pinto, Yago O.; Andrade, C. R. G; Mesquita, Felipe Pantoja; Silva, Gabrielly O.; Freitas, Cléverson D.T.; Souza, Pedro Filho Noronha

doi:10.1007/s11101-023-09875-y

Cited by 8 publications

(3 citation statements)

References 88 publications

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“…The antioxidant capacity of these peptides is closely related to their amino acid composition, length, molecular structure, and hydrophobicity [39]. In addition, factors such as the type of substrate, the specificity of the enzyme, and the reaction time and temperature during the enzymatic hydrolysis may affect the molecular weight and amino acid sequence of the peptide, which in turn affect its biological activity [40]. Aspergillus niger is a common and important fermenting strain and one of the excellent producers of valuable proteases.…”

Section: Discussionmentioning

confidence: 99%

Optimization of Fermentation Process of Wheat Germ Protein by Aspergillus niger and Analysis of Antioxidant Activity of Peptide

Liu,

Zhou,

Zhu

et al. 2024

Fermentation

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Utilizing wheat embryos as the raw material and employing Aspergillus niger as the fermentation strain, wheat embryo polypeptides were produced through microbial liquid fermentation. The protein concentration post-fermentation served as the response variable, and the preparation process underwent optimization through single-factor testing and a response surface methodology, followed by the assessment of antioxidant activity. The findings revealed that the optimal conditions for wheat embryo peptide preparation via Aspergillus niger fermentation included a fermentation duration of 24 h, an inoculum volume of 4%, an initial pH of 7, and a protein concentration of 21.47 mg/mL. Peptides with different molecular weights were then prepared by dead-end filtration. The results showed that F6 (<3 kDa) had strong scavenging ability against DPPH, ABTS, and ·OH radicals, which provided a basis for the preparation of antioxidant peptides in wheat germ and related research.

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Section: Discussionmentioning

confidence: 99%

Optimization of Fermentation Process of Wheat Germ Protein by Aspergillus niger and Analysis of Antioxidant Activity of Peptide

Liu,

Zhou,

Zhu

et al. 2024

Fermentation

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“…Plants are excellent sources of natural biopeptides, even though plant proteins are found in smaller quantities in crops eaten by plant-eating animals or in the leftover materials from agricultural and industrial processes (César et al, 2024). Nonetheless, due to their benefits, such as high production rates, cost-effectiveness, short harvesting times, lack of conflict with regional religious or cultural practices, and remarkable biological effectiveness, plantbased proteins are increasingly being explored as ideal starting materials for the production of bioactive peptides (Hossain et al, 2022;Senadheera et al, 2023;Yeo and Shahidi, 2020).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Bioactive Peptides as Antioxidants and Antimicrobials: Fundamentals and Applications

Kumari,

Shahidi

2024

JFB

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Bioactive peptides are well-known for their remarkable tissue affinity, specificity, and effectiveness in promoting health. Extracted from food proteins, these bioactive peptides have displayed significant potential as functional foods and nutraceuticals. Throughout the years, numerous potential bioactive peptides derived from food sources have been documented. These bioactive peptides offer a wide range of crucial functions within the human body, including acting as antioxidants, antimicrobial agents, anti-inflammatory compounds, anti-hypertensive substances, and immunomodulators. More recently, extensive research has been conducted to investigate the origins, bioavailability, potential physiological effects and functionality, as well as the mechanisms of action of bioactive peptides in rendering health benefits. Researchers have also delved into various technological methods for preparing, purifying, and characterizing these peptides. This contribution primarily centers on exploring the antioxidant and antimicrobial aspects of bioactive peptides.

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“…These bioactive peptides, whether derived from dietary proteins or synthesized, have demonstrated substantial ROS scavenging activity, offering potential benefits for human health promotion. Review papers that address this topic have been published recently [201][202][203][204][205][206].…”

Section: Protein-based Nanoformulationsmentioning

confidence: 99%

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Stevanović,

Filipović

2024

Pharmaceutics

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In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, the healthcare landscape is constantly evolving, necessitating the continual development of innovative therapeutic approaches and drug delivery systems (DDSs). DDSs play a pivotal role in enhancing treatment efficacy, minimizing adverse effects, and optimizing patient compliance. Among these, nanotechnology-driven delivery approaches have garnered significant attention due to their unique properties, such as improved solubility, controlled release, and targeted delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., offer versatile platforms for drug delivery and tissue engineering applications. Additionally, biopolymer-based DDSs hold immense promise, leveraging natural or synthetic biopolymers to encapsulate drugs and enable targeted and controlled release. These systems offer numerous advantages, including biocompatibility, biodegradability, and low immunogenicity. The utilization of polysaccharides, polynucleotides, proteins, and polyesters as biopolymer matrices further enhances the versatility and applicability of DDSs. Moreover, substances with antioxidative properties have emerged as key players in combating oxidative stress-related diseases, offering protection against cellular damage and chronic illnesses. The development of biopolymer-based nanoformulations with antioxidative properties represents a burgeoning research area, with a substantial increase in publications in recent years. This review provides a comprehensive overview of the recent developments within this area over the past five years. It discusses various biopolymer materials, fabrication techniques, stabilizers, factors influencing degradation, and drug release. Additionally, it highlights emerging trends, challenges, and prospects in this rapidly evolving field.

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Antioxidant peptides from plants: a review

Cited by 8 publications

References 88 publications

Optimization of Fermentation Process of Wheat Germ Protein by Aspergillus niger and Analysis of Antioxidant Activity of Peptide

Optimization of Fermentation Process of Wheat Germ Protein by Aspergillus niger and Analysis of Antioxidant Activity of Peptide

Bioactive Peptides as Antioxidants and Antimicrobials: Fundamentals and Applications

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

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