Antioxidant Nutrition and Immunity

Harbige, Laurence S.; Gershwin, M. Eric

doi:10.1007/978-1-59259-790-1_9

Cited by 2 publications

(2 citation statements)

References 93 publications

(57 reference statements)

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“…Because of the diversity of fungi in the environment, several fungal infections regularly affect most people without adverse reactions; however, the weakening of the immune system can cause the fungi to overgrow and cause symptoms [55]. Nutritional antioxidants can aid the immune system to inhibit the growth of a number of fungi thereby overcoming fungal symptoms [56]. Consequently, the antioxidant nature of the essential oils from S. aromaticum might have aided in inhibiting the fungal growth.…”

Section: Discussionmentioning

confidence: 99%

Eugenol-Rich Essential Oils from Flower Buds and Leaves of Syzygium aromaticum Unveils Antifungal Activity against Candida and Cryptococcus Species

Momo,

Nguimatsia,

Ateufouet Ngouango

et al. 2024

Preprint

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Plants from the Myrtaceae family are well known to contain considerable amounts of volatile compounds, ranging from oxygenated monoterpenes to hydrogenated sesquiterpenes, and others, which exhibit antimicrobial activity. One such plant includes Syzygium aromaticum that has been extensively used to treat a number of disorders, including bacterial and fungal infections. Thus, the scientific validation of the essential oil (EO) of Syzygium aromaticum vis-à-vis Candida and Cryptococcus species is valuable. To this end, the present study sought to investigate the antifungal activity of EO from S. aromaticum (clove) leaves and flower buds against Candida and Cryptococcus species. The antioxidant activity of S. aromaticum’s essential oils is also elucidated. The EO was extracted from fresh leaves and floral buds of S. aromaticum using a Clevenger-type apparatus. The as-prepared essential oils were further evaluated for antifungal activity against Candida and Cryptococcus species using a microdilution method. The phytochemical analysis of the EOs was assessed by gas chromatography/mass spectrometry (GC-MS). Antioxidant activities of the EOs were evaluated using standard methods. As a result, the GC-MS analysis revealed the presence of volatile compounds, such as eugenol (87.08%), β-caryophyllene (6.40%) and acetyleugenol (4.45%) as the major constituents of EO from the flower buds ; and eugenol (90.54%) and β-caryophyllene (24.65%) as the major components of the leaf’s EO. The eugenol-rich essential oils exhibited significant antifungal effects against Candida species (common MIC value: 200 ppm) and Cryptococcus neoformans (MIC value: 50 ppm), as well as antioxidant activity. Overall, essential oils of S. aromaticum demonstrated an-tioxidant and antifungal effects, thus validating the ethnopharmacological use of this plant in the treatment of fungal infections. However, antifungal mechanisms of action, in-depth toxicity and in vivo experiments, and pharmacokinetics are warranted to support the use of this plant in ethnomedicine.

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Section: Discussionmentioning

confidence: 99%

Eugenol-Rich Essential Oils from Flower Buds and Leaves of Syzygium aromaticum Unveils Antifungal Activity against Candida and Cryptococcus Species

Momo,

Nguimatsia,

Ateufouet Ngouango

et al. 2024

Preprint

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“…97]. In the elderly, immunological dysfunctions may occur because of single nutrient deficiencies, such as of vitamin A, iron or zinc, or because of multiple nutrient deficiencies in conjunction with general malnutrition [47,[98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114] and protein-energy malnutrition [115,116], many of which can be reversed by nutritional supplementation interventions [117,118].…”

Section: Nutrition and Immunity In The Elderly 241 Under-nutritionmentioning

confidence: 99%

Aging, nutrition and immunity – their relationship and interaction

Alam

Pawelec

2012

Nutrition and Aging

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Demographic shifts worldwide are resulting in ever-increasing numbers of the elderly in both developed and developing countries. With aging come changes in physical and physiological integrity that are accompanied by a gradual decline in immunocompetence, commonly termed 'immunosenescence'. Indeed, there are marked differences between young and old subjects with respect to the proportions of naïve and memory T cells and less marked differences in B cells and other immune cells. The number and proportion of late-stage memory T and B cells commonly increases, being particularly prominent in the CD8+ cytotoxic T cell pool. The accumulation of late-stage potentially "terminally" differentiated CD8+CD27−CD28−CD45RA+ cells is often considered a hallmark of immunosenescence. Malnutrition in old age can further add to the severity of this age-associated remodeling of the immune system. Age-associated obesity, in particular, is accompanied by greater chronic inflammation, as reflected in increased plasma concentrations of C-reactive protein (CRP), IL-6, TNF and other factors which may mark compromised immunity. These physiological and immunological changes accompanying aging, markedly affected by nutritional status, are likely to be different in different parts of the globe. Data suggest a gradual decline in both nutritional status and immune functions with aging, but the details of these processes, and potential differences in different societies are unclear. In the following review, we will discuss the hallmarks of age-associated immune system changes and consider how these might be affected by nutritional status.

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Antioxidant Nutrition and Immunity

Cited by 2 publications

References 93 publications

Eugenol-Rich Essential Oils from Flower Buds and Leaves of <em>Syzygium aromaticum</em> Unveils Antifungal Activity against <em>Candida </em>and <em>Cryptococcus </em>Species

Eugenol-Rich Essential Oils from Flower Buds and Leaves of <em>Syzygium aromaticum</em> Unveils Antifungal Activity against <em>Candida </em>and <em>Cryptococcus </em>Species

Aging, nutrition and immunity – their relationship and interaction

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