Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children

Abstract

Background/Objectives: To investigate the association of antioxidant nutritional status with the risk of atopic dermatitis (AD) in young children in a case-control, population-based study. Subjects/Methods: Identified from preschools by using the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC). Final analysis included 180 AD (mean age 5.3 ± 0.9 years) and 242 non-AD (mean age 5.2 ± 1.0 years) children. Diet was assessed using a validated semi-quantitative food frequency questionnaire. Fasting blood samples were used for analyses of fat-soluble vitamins (retinol, a-tocopherol, and b-carotene) and vitamin C. . There was no relationship of AD risk with dietary and plasma vitamin C as well as nutrient supplement intake regardless of nutrient type. AD was predicted better by the intake measure than the corresponding blood biomarker regarding vitamin E and b-carotene. Conclusions: These findings suggest that higher antioxidant nutritional status reduces the risk of AD and that such risk-reduction effects depend on nutrient type.

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

“…Impairment of the skin barrier and imbalance in the ratios of Th1/Th2 and Tregs/Th17 are key contributors to the pathogenesis of AD, suggesting a potential link between VA and AD. Recently, Oh et al [20] found that serum VA concentrations are lower in children with AD, regardless of the level ingested from food or found in the serum, and that AD was negatively associated with the intake of antioxidant-related nutrients (including VA and β-carotene). Their findings suggested that VAD increases the risk of AD, consistent with our own conclusions.…”

“…However, few reports have explored the correlation between AD and VA to date. Oh et al [20] reported that the incidence of AD was negatively correlated with the intake of antioxidant nutrients (including retinol and β-carotene), and Mihály et al [21] found decreased retinoid concentration and retinoid signalling pathways in human AD patients. Our previous studies demonstrated that VA and VD co-deficiency may exacerbate the symptoms of children with autism spectrum disorders [22].…”

β-Carotene Concentration and Its Association with Inflammatory Biomarkers in Spanish Schoolchildren

“…The present results are important because the inflammatory status of the subjects was associated with inadequate plasma β-carotene levels, a situation that could increase the risk of developing diabetes or metabolic syndrome [1,2,3,4]. Furthermore, our findings also have important implications because, as reported by other authors, it seems unwise to interpret biomarker data as prima facie evidence of dietary intake without a more complete understanding of the physiological processes that affect nutrient plasma levels [14], such as the inflammatory state.…”

“…β-Carotene has antioxidant activity and has been related to the prevention of allergies, diabetes and metabolic syndrome; therefore, maintaining an adequate β-carotene status from childhood onward is vital [1,2,3,4]. Nevertheless, a remarkable prevalence of β-carotene deficiency has been reported in children (41.5%) [5] and adolescents (25%) [6].…”

Immune biomarkers in the spectrum of childhood noncommunicable diseases

“…This highlights the link between the microbiome, intestinal inflammation and allergic disease and the potential utility of monitoring gut health for predictive biomarkers in multiple disease settings. Similarly, nutritional status could be monitored through biomarkers 60 as could environmental exposures that effect disease manifestation 61 . Candidate approaches have also been undertaken using umbilical cord blood.…”