Antioxidant Nanoplatforms for Dermal Delivery: Melatonin

Milan, Aroha Sanchez; Campmany, Ana Cristina Calpena; Naveros, Beatriz Clarés

doi:10.2174/1389200218666170222145908

Cited by 13 publications

(11 citation statements)

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“…However, apart from their antioxidant properties, the mechanisms of actions through which assayed vitamins exert the healing action are confusing and controversial [59][60][61]. On the other hand, antiapoptotic and p53-inhibitory processes seem to be involved in the healing mechanism of MLT [62].…”

Section: Discussionmentioning

confidence: 99%

Endogenous Antioxidant Cocktail Loaded Hydrogel for Topical Wound Healing of Burns

et al. 2020

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The main goal of this work is the study of the skin wound healing efficacy of an antioxidant cocktail consisting of vitamins A, D, E and the endogenous pineal hormone melatonin (MLT), with all of these loaded into a thermosensitive hydrogel delivery system. The resulting formulation was characterized by scanning electron microscopy. The antioxidant efficacy and microbiological activity against Gram positive and Gram negative strains were also assayed. The skin healing efficacy was tested using an in vivo model which included histological evaluation. Furthermore, atomic force microscopy was employed to evaluate the wound healing efficacy of rat skin burns through the determination of its elasticity at the nanoscale using force spectroscopy analysis. The resulting hydrogel exhibited sol state at low temperature and turned into a gel at 30 ± 0.2 °C. The hydrogel containing the antioxidant cocktail showed higher scavenging activity than the hydrogel containing vitamins or MLT, separately. The formulation showed optimal antimicrobial activity. It was comparable to a commercial reference. It was also evidenced that the hydrogel containing the antioxidant cocktail exhibited the strongest healing process in the skin burns of rats, similar to the assayed commercial reference containing silver sulfadiazine. Histological studies confirmed the observed results. Finally, atomic force microscopy demonstrated a similar distribution of Young’s modulus values between burned skin treated with the commercial reference and burned skin treated with hydrogel containing the antioxidant cocktail, and all these with healthy skin. The use of an antioxidant cocktail of vitamins and MLT might be a promising treatment for skin wounds for future clinical studies.

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Section: Discussionmentioning

confidence: 99%

Endogenous Antioxidant Cocktail Loaded Hydrogel for Topical Wound Healing of Burns

et al. 2020

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“…Orally ingested melatonin is rapidly metabolized in the liver by CYP450 into 6-hydroxymelatonin while sublingual (transmucosal) melatonin administration can bypass liver metabolism. Transdermal application of melatonin appears to be optimal for local application due to slow absorption, deposition in the skin, lack of identifiable site effects, and availability of different formulations (Flo et al, 2016, 2017; Milan et al, 2017; Romic et al, 2016; Scheuer et al, 2016b; Zetner et al, 2016). Because there is a cutaneous melatonin metabolism with metabolites sharing similar activities as melatonin (Slominski et al, 2017b), the effects summarized in the central column may also be secondary to the action of its metabolites.…”

Section: Figurementioning

confidence: 99%

Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions

Słomiński

Hardeland

Żmijewski

et al. 2018

Journal of Investigative Dermatology

232

217

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Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. Although melatonin is best known to regulate circadian rhythmicity and lower vertebrate skin pigmentation, the full spectrum of functional activities of this free radical-scavenging molecule, which also induces/promotes complex antioxidative and DNA repair systems, includes immunomodulatory, thermoregulatory, and antitumor properties. Because this plethora of functional melatonin properties still awaits to be fully appreciated by dermatologists, the current review synthesizes the main features that render melatonin a promising candidate for the management of several dermatoses associated with substantial oxidative damage. We also review why melatonin promises to be useful in skin cancer prevention, skin photo- and radioprotection, and as an inducer of repair mechanisms that facilitate the recovery of human skin from environmental damage. The fact that human skin and hair follicles not only express functional melatonin receptors but also engage in substantial, extrapineal melatonin synthesis further encourages one to systematically explore how the skin's melatonin system can be therapeutically targeted in future clinical dermatology and enrolled for preventive medicine strategies.

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“…Poly(D,L-lactide-co-glycolide) (PLGA) polymers have been used for the preparation of nanoparticles and microparticles loaded with melatonin [35,36]. Both of them are prepared by the emulsion-diffusion-evaporation method and the addition of 0.2% (w/v) melatonin in the aqueous phase.…”

Section: Polymeric Nanoparticles and Polymer-based Drug Delivery Nanomentioning

confidence: 99%

“…Both of them are prepared by the emulsion-diffusion-evaporation method and the addition of 0.2% (w/v) melatonin in the aqueous phase. The size of nanoparticles was about 200 nm and the entrapment efficiency around 14%, while the size of microparticles was about 3.5 micrometers and the encapsulation efficiency 27% [35,36]. The toxicity and the effectiveness of the prepared systems are also evaluated using cell lines.…”

Section: Polymeric Nanoparticles and Polymer-based Drug Delivery Nanomentioning

confidence: 99%

The Release Kinetics of Melatonin from Innovative Dosage Forms: The Role of the Fractal Geometry of the “Vehicle”

Pippa¹,

Demetzos²

2020

Melatonin - The Hormone of Darkness and Its Therapeutic Potential and Perspectives

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Melatonin (N-acetyl-5-methoxytryptamine) is an antioxidant active pharmaceutical ingredient with numerous applications as medicine and nutraceutical. Melatonin, a hormone synthesized by the pineal gland, has a significant role in the regulation of the circadian biological clock. The aim of this chapter is to present the conventional solid and liquid forms (i.e., tables, capsules, suspensions, etc.) and the nanoformulations (i.e., liposomes, niosomes, polymeric nanoparticles, chitosomes, calcium alginate beads, etc.) of melatonin and to give special attention to its release kinetics from the pharmaceutical vehicle. These systems have been designed and developed as platforms for the delivery and release of melatonin. In all cases, the controlled release of melatonin is the main goal of its loading into drug delivery platforms. Fractal analysis is a mathematical tool to quantify nature and physical systems' complexity. These systems have been characterized as fractal objects, due to their fractional dimensions. In this chapter, we are probing the interrelationship between the fractal dimension of pharmaceutical vehicle and the release profile of melatonin. Several examples will be given in order to understand in depth the reason of controlledrelease profile of melatonin and its added value for the development of a new medicine and/or nutraceutical.

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Antioxidant Nanoplatforms for Dermal Delivery: Melatonin

Cited by 13 publications

References 0 publications

Endogenous Antioxidant Cocktail Loaded Hydrogel for Topical Wound Healing of Burns

Endogenous Antioxidant Cocktail Loaded Hydrogel for Topical Wound Healing of Burns

Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions

The Release Kinetics of Melatonin from Innovative Dosage Forms: The Role of the Fractal Geometry of the “Vehicle”

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