Antioxidant metabolism induced by quinic acid. increased urinary excretion of tryptophan and nicotinamide

Abstract

For over 50 years, hippuric/quinic acids were believed to have no biological efficacy. Here data are presented to support the hypothesis that quinic acid is not responsible for any efficacy, but rather that quinic acid nutritionally supports the synthesis of tryptophan and nicotinamide in the gastrointestinal (GI) tract, and that this in turn leads to DNA repair enhancement and NF-kB inhibition via increased nicotinamide and tryptophan production.Moreover, it is shown that quinic acid is a normal constituent of our diet, capable of conversion to tryptophan and nicotinamide via the GI tract microflora, thus providing an in situ physiological source of these essential metabolic ingredients to humans. The concentrations of quinic and hippuric acids in the diet were dependent on each other when analysed in urine, as was evidenced by a significant linear regression analysis that included unsupplemented control subjects (n = 45, p < 0.001). Thus, these ingredients were identified as major dietary components, and not simply originating from environmental pollution as previously had been thought.

Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC–ESI-MS/MS

“…On this context, it could be said that C. humilis is a good source of quinic acid. Many studies in the literature showed that quinic acid has a potent broad spectrum antioxidant (Pero et al, 2009), hepatoprotective (Xiang et al, 2001) and can be used to combat prostate cancer (Onbathamizh & Padmini, 2013).…”

Enhancing DNA Repair by Combining only Dietary Supplement Ingredients that do not Metabolically Compete in Order to Achieve Synergism

“…4. The mode of action of CAEs/QAEs is via stimulating uptake of tryptophan and nicotinamide (Pero et al 2009b, Pero andLund 2011). There are no other DNA repair enhancing substances having this mode of action.…”

“…A water extract of Cat's Claw (Uncaria species) called AC-11 or one of its active ingredients quinic acid are also DNA repair enhancers that do not metabolically compete with resveratrol material, carotenoid material, nicotinamide material, DMAE material or zinc material, and as such could be added to the DNA repair mixture without inducing metabolic competition and thus inhibiting DNA repair instead of being synergistic, because the mode of action of AC-11/quinic acid to increasing DNA repair is novel to inducing DNA repair by increasing uptake of urinary tryptophan and nicotinamide (Pero 2008, Pero et al 2009b, Pero and Lund 2009a, 2011. The quinic acid analog being selected for commericial development is from the group consisting of quinic acid salts, chelates, and Uncaria or other plant extracts containing quinic acid analogs (Pero 2001(Pero , 2002(Pero , 2005(Pero , 2006(Pero , 2009a(Pero , 2009bPero and Garret 2010a).…”

“…The quinic acid analog being selected for commericial development is from the group consisting of quinic acid salts, chelates, and Uncaria or other plant extracts containing quinic acid analogs (Pero 2001(Pero , 2002(Pero , 2005(Pero , 2006(Pero , 2009a(Pero , 2009bPero and Garret 2010a).…”

Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents

“…QA has been confirmed as antioxidant, and extends its mode of action to include a basic nutritional benefit due to the enhanced metabolism of both tryptophan and nicotinamide. 70 But QA was not showing its ability to trap free radicals by DPPH testing method. 71 CGA and CA derivatives possess radical scavenging activity.…”